Results 21 to 30 of about 11,489 (200)
Indonesian Journal of Biotechnology, 2015 Marine actinomycetes is a group of bacteria that is highly potential in producing novel bioactive compound. It has unique characteristics and is different from other terrestrial ones.
Camelia Herdini +8 more
doaj +1 more source
High-throughput reprogramming of an NRPS condensation domain
Nature Chemical Biology, 2023 Abstract Engineered biosynthetic assembly lines could revolutionize the sustainable production of bioactive natural product analogs. Although yeast display is a proven, powerful tool for altering the substrate specificity of gatekeeper adenylation domains in nonribosomal peptide synthetases (NRPSs), comparable strategies for other ...
Ines B. Folger +6 more
openaire +4 more sources
Promiscuity‐Guided Enzyme Evolution via Substrate Multiplexed Screening
Angewandte Chemie, EarlyView.Through historical context and recent examples, this Minireview summarizes the strengths, limitations, and practical considerations for the implementation of substrate multiplexed screening (SUMS) in enzyme evolution. ABSTRACT An enzyme's ability to react with diverse substrates while maintaining high yield and selectivity, termed “substrate ...
Holly A. Weilbaker +3 more
wiley +2 more sources
Impact of pension income on healthcare utilization of older adults in rural China
International Journal for Equity in Health, 2023 Objective In China, rural residents experience poorer health conditions and a higher disease burden compared to urban residents but have lower healthcare services utilization. Rather than an insurance focus on enhanced healthcare services utilization, we
Peizhe Yan +6 more
doaj +1 more source
Angewandte Chemie, EarlyView.The fischerazoles, unusual cyanobacterial chlorinated lipopeptides are reported. During their biosynthesis, a linear fatty acyl‐acyl carrier protein (ACP) precursor is rearranged through the action of the S‐adenosyl‐methionine (SAM)‐dependent methyltransferase FshF, to generate a pendant vinyl group.
Sandra A. C. Figueiredo +8 more
wiley +2 more sources
PLoS ONE, 2015 The ever increasing microbial resistome means there is an urgent need for new antibiotics. Metagenomics is an underexploited tool in the field of drug discovery. In this study we aimed to produce a new updated assay for the discovery of biosynthetic gene
Gregory C A Amos +9 more
doaj +1 more source
Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering. [PDF]
PLoS ONE, 2016 Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) each give rise to a vast array of complex bioactive molecules with further complexity added by the existence of natural PKS-NRPS fusions.
Maria Lund Nielsen +6 more
doaj +1 more source
BMC Genomics, 2009 Background Cyanobacteria often produce several different oligopeptides, with unknown biological functions, by nonribosomal peptide synthetases (NRPS).
Nederbragt Alexander J +4 more
doaj +1 more source
How Does China’s New Rural Pension Scheme Affect Agricultural Production?
Agriculture, 2022 This study examines the spillover effects of China’s New Rural Pension Scheme (NRPS) implemented in 2009 as a cash transfer program for agricultural production.
Xing Ji, Jingwen Xu, Hongxiao Zhang
doaj +1 more source
Nature’s Antimicrobial Arsenal: Non-Ribosomal Peptides from PGPB for Plant Pathogen Biocontrol
Fermentation, 2023 Non-ribosomal peptides (NRPs) are a diverse group of bioactive compounds synthesized by microorganisms, and their antimicrobial properties make them ideal candidates for use as biocontrol agents against pathogens. Non-ribosomal peptides produced by Plant-
Anuj Ranjan +12 more
doaj +1 more source