Results 21 to 30 of about 11,913 (171)

A genome-wide analysis of nonribosomal peptide synthetase gene clusters and their peptides in a Planktothrix rubescens strain

BMC Genomics, 2009
Background Cyanobacteria often produce several different oligopeptides, with unknown biological functions, by nonribosomal peptide synthetases (NRPS).
Nederbragt Alexander J, Rohrlack Thomas, Rounge Trine B, Kristensen Tom, Jakobsen Kjetill S   +4 more
doaj   +1 more source

Nature’s Antimicrobial Arsenal: Non-Ribosomal Peptides from PGPB for Plant Pathogen Biocontrol

Fermentation, 2023
Non-ribosomal peptides (NRPs) are a diverse group of bioactive compounds synthesized by microorganisms, and their antimicrobial properties make them ideal candidates for use as biocontrol agents against pathogens. Non-ribosomal peptides produced by Plant-
Anuj Ranjan, Vishnu D. Rajput, Evgeniya Valeryevna Prazdnova, Manisha Gurnani, Pallavi Bhardwaj, Shikha Sharma, Svetlana Sushkova, Saglara S. Mandzhieva, Tatiana Minkina, Jebi Sudan, Sajad Majeed Zargar, Abhishek Chauhan, Tanu Jindal   +12 more
doaj   +1 more source

Diversity of Gene Clusters for Polyketide and Nonribosomal Peptide Biosynthesis Revealed by Metagenomic Analysis of the Yellow Sea Sediment

Frontiers in Microbiology, 2018
Polyketides (PKs) and nonribosomal peptides (NRPs) are widely applied as drugs in use today, and one potential source for novel PKs and NRPs is the marine sediment microbes.
Yongjun Wei, Lei Zhang, Zhihua Zhou, Xing Yan   +3 more
doaj   +1 more source

Lincosamide synthetase--a unique condensation system combining elements of nonribosomal peptide synthetase and mycothiol metabolism. [PDF]

PLoS ONE, 2015
In the biosynthesis of lincosamide antibiotics lincomycin and celesticetin, the amino acid and amino sugar units are linked by an amide bond. The respective condensing enzyme lincosamide synthetase (LS) is expected to be an unusual system combining ...
Jiri Janata, Stanislav Kadlcik, Marketa Koberska, Dana Ulanova, Zdenek Kamenik, Petr Novak, Jan Kopecky, Jitka Novotna, Bojana Radojevic, Kamila Plhackova, Radek Gazak, Lucie Najmanova   +11 more
doaj   +1 more source

The structural basis of N-acyl-α-amino-β-lactone formation catalyzed by a nonribosomal peptide synthetase

Nature Communications, 2019
The antimicrobial β-lactone obafluorin is produced by a Nonribosomal Peptide Synthetase (NRPS). Here the authors present the crystal structure of the obafluorin NRPS and develop a reconstitution assay that allows them to analyse product formation from ...
Dale F. Kreitler, Erin M. Gemmell, Jason E. Schaffer, Timothy A. Wencewicz, Andrew M. Gulick   +4 more
doaj   +1 more source

Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions

Advanced Science, EarlyView.
Polychip, a fully integrated droplet microfluidics platform, enables high‐throughput, single‐cell resolution screening of polymicrobial interactions. By seamlessly combining six automated microfluidics operations on a single chip, the system accelerates antimicrobial discovery by 11 to 14 times compared to traditional robotic methods.
Jeong Jae Han, Adrian Ryan Guzman, Aifen Zhou, Han Zhang, Rohit Gupte, Haemin Jung, Kaylee Delgado, Sini Skariah, Ali Sultan, Arul Jayaraman, Paul de Figueiredo, Arum Han   +11 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Kluster Gen Biosintetik (NRPS/PKS) Pada Bakteri Sedimen Mangrove Pantai Tirang Semarang Indonesia

Jurnal Kelautan Tropis
This study aims to explore biosynthetic gene clusters and antibacterial activity in mangrove sediment bacteria at Tirang Beach, Semarang, Central Java. Research methods include isolating bacteria from seagrass sediments, antibacterial testing against S ...
Barra Muzaffar Widayat, Delianis Pringgenies, Wilis Ari Setyati   +2 more
doaj   +1 more source

An Engineered Synthetic Pathway for Discovering Nonnatural Nonribosomal Peptides in Escherichia coli

mBio, 2017
Peptides that are synthesized independently of the ribosome in plants, fungi, and bacteria can have clinically relevant anticancer, antihemochromatosis, and antiviral activities, among many other.
Sara Cleto, Timothy K. Lu
doaj   +1 more source

Nerpa: A Tool for Discovering Biosynthetic Gene Clusters of Bacterial Nonribosomal Peptides

Metabolites, 2021
Microbial natural products are a major source of bioactive compounds for drug discovery. Among these molecules, nonribosomal peptides (NRPs) represent a diverse class of natural products that include antibiotics, immunosuppressants, and anticancer agents.
Olga Kunyavskaya, Azat M. Tagirdzhanov, Andrés Mauricio Caraballo-Rodríguez, Louis-Félix Nothias, Pieter C. Dorrestein, Anton Korobeynikov, Hosein Mohimani, Alexey Gurevich   +7 more
doaj   +1 more source