Results 11 to 20 of about 11,489 (200)
Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
BMC Genomics, 2019 Background Filamentous fungi produce a vast amount of bioactive secondary metabolites (SMs) synthesized by e.g. hybrid polyketide synthase-nonribosomal peptide synthetase enzymes (PKS-NRPS; NRPS-PKS).
Sebastian Theobald +2 more
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Expression of NRP-1 and NRP-2 in Endometrial Cancer [PDF]
Current Pharmaceutical Biotechnology, 2019 Background:Neuropilins (NRPs) participate in many processes related to cancer development such as angiogenesis, lymphangiogenesis and metastasis. Although endometrial cancer is one of the most common gynecological cancers, it has not been studied in terms of NRPs expression.Objective:The aim of this study was to investigate the potential utility of ...
Opławski, Marcin +8 more
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NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases [PDF]
Nucleic Acids Research, 2004 NRPS-PKS is web-based software for analysing large multi-enzymatic, multi-domain megasynthases that are involved in the biosynthesis of pharmaceutically important natural products such as cyclosporin, rifamycin and erythromycin. NRPS-PKS has been developed based on a comprehensive analysis of the sequence and structural features of several ...
Mohd. Zeeshan Ansari +3 more
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Pediatrics, 2017 We commend the authors for this randomized controlled study and their finding that infants aged
Lawrence, Noble, Ivan, Hand
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Ecological Indicators, 2021 Nonribosomal peptides (NRPs) and polyketides (PKs) have widely been widely applied in clinical drugs in use today, and one of the main sources for novel NRPs and PKs is soil microbes. However, the diversity of soil bacteria and distribution of their NRPs
Haipeng Zhang +10 more
doaj +1 more source
BMC Public Health, 2023 Background Many researchers have examined the impact of social insurance on health in elderly. However, in most cases, they have only demonstrated correlational results and have not been able to determine causal effects, possibly because confounding ...
Qihong Liang +3 more
doaj +1 more source
Neonatal resuscitation: the NRP guidelines [PDF]
Canadian Journal of Anaesthesia, 1994 The Neonatal Resuscitation Programme, sponsored by the Canadian Heart and Stroke Foundation and by the American Heart Association, is a structured learning package and workshop for all individuals who provide resuscitation for newborns. The emphasis is on rapid, decisive action using algorithms based on clearly stated criteria.
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Beilstein Journal of Organic Chemistry, 2019 The argyrins are secondary metabolites from myxobacteria with antibiotic activity against Pseudomonas aeruginosa. Studying their structure–activity relationship is hampered by the complexity of the chemical total synthesis.
David C. B. Siebert +6 more
doaj +1 more source
Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery
Nature Communications, 2021 Current genome mining methods predict many putative non-ribosomal peptides (NRPs) from their corresponding biosynthetic gene clusters, but it remains unclear which of those exist in nature and how to identify their post-assembly modifications.
Bahar Behsaz +15 more
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Neuropilin (NRPs) Related Pathological Conditions and Their Modulators
International Journal of Molecular Sciences, 2022 Neuropilin 1 (NRP1) represents one of the two homologous neuropilins (NRP, splice variants of neuropilin 2 are the other) found in all vertebrates. It forms a transmembrane glycoprotein distributed in many human body tissues as a (co)receptor for a variety of different ligands.
Matic Broz +3 more
openaire +4 more sources