Results 11 to 20 of about 11,913 (171)

Gene sequence diversity of the nonribosomal peptide and polyketide natural products in Changbaishan soil correlates with changes in landscape belts

Ecological Indicators, 2021
Nonribosomal peptides (NRPs) and polyketides (PKs) have widely been widely applied in clinical drugs in use today, and one of the main sources for novel NRPs and PKs is soil microbes. However, the diversity of soil bacteria and distribution of their NRPs
Haipeng Zhang, Yuehua Liu, Xinhai Wang, Renge Hu, Guanyi Xu, Changsi Mao, Muhammad Inam, Yiming Wang, Xiuyun Jiang, Lingcong Kong, Hongxia Ma   +10 more
doaj   +1 more source

Do the New Rural Pension Scheme promote the health status of chronic patients in old age? —Evidence from CHARLS 2018 in China

BMC Public Health, 2023
Background Many researchers have examined the impact of social insurance on health in elderly. However, in most cases, they have only demonstrated correlational results and have not been able to determine causal effects, possibly because confounding ...
Qihong Liang, Yuxuan Chen, Zheng Zhang, Shengli An   +3 more
doaj   +1 more source

Chemical synthesis of tripeptide thioesters for the biotechnological incorporation into the myxobacterial secondary metabolite argyrin via mutasynthesis

Beilstein Journal of Organic Chemistry, 2019
The argyrins are secondary metabolites from myxobacteria with antibiotic activity against Pseudomonas aeruginosa. Studying their structure–activity relationship is hampered by the complexity of the chemical total synthesis.
David C. B. Siebert, Roman Sommer, Domen Pogorevc, Michael Hoffmann, Silke C. Wenzel, Rolf Müller, Alexander Titz   +6 more
doaj   +1 more source

Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery

Nature Communications, 2021
Current genome mining methods predict many putative non-ribosomal peptides (NRPs) from their corresponding biosynthetic gene clusters, but it remains unclear which of those exist in nature and how to identify their post-assembly modifications.
Bahar Behsaz, Edna Bode, Alexey Gurevich, Yan-Ni Shi, Florian Grundmann, Deepa Acharya, Andrés Mauricio Caraballo-Rodríguez, Amina Bouslimani, Morgan Panitchpakdi, Annabell Linck, Changhui Guan, Julia Oh, Pieter C. Dorrestein, Helge B. Bode, Pavel A. Pevzner, Hosein Mohimani   +15 more
doaj   +1 more source

Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl-Substituted, α-Oxidized γ-Amino Acids. [PDF]

Angew Chem Int Ed Engl
Genome mining of atypical condensation (C) domains leads to the discovery of myxoglucamides, glycolipopeptides featuring an unprecedented vinyl‐substituted, α‐oxidized γ‐amino acid. Biosynthetic studies reveal a discrete C‐domain‐like O‐acyltransferase, a β‐hydroxylation‐dependent chain‐extension checkpoint, and an unusual pathway for γ‐amino acid ...
Wang T, Popoff A, Hunter M, Dai G, Garcia R, Xu H, Zhao H, Sikandar A, Huo L, Müller R, Fu C.   +10 more
europepmc   +3 more sources

Diversity of Nonribosomal Peptide Synthetase Genes in the AnticancerProducing Actinomycetes Isolated from Marine Sediment in Indonesia

Indonesian Journal of Biotechnology, 2015
Marine actinomycetes is a group of bacteria that is highly potential in producing novel bioactive compound. It has unique characteristics and is different from other terrestrial ones.
Camelia Herdini, Shinta Hartanto, Sofia Mubarika, Bambang Hariwiyanto, Nastiti Wijayanti, Akira Hosoyama, Atsushi Yamazoe, Hideaki Nojiri, Jaka Widada   +8 more
doaj   +1 more source

Impact of pension income on healthcare utilization of older adults in rural China

International Journal for Equity in Health, 2023
Objective In China, rural residents experience poorer health conditions and a higher disease burden compared to urban residents but have lower healthcare services utilization. Rather than an insurance focus on enhanced healthcare services utilization, we
Peizhe Yan, Fenghang Li, Stephen Nicholas, Elizabeth Maitland, Jialong Tan, Chen Chen, Jian Wang   +6 more
doaj   +1 more source

Designing and Implementing an Assay for the Detection of Rare and Divergent NRPS and PKS Clones in European, Antarctic and Cuban Soils.

PLoS ONE, 2015
The ever increasing microbial resistome means there is an urgent need for new antibiotics. Metagenomics is an underexploited tool in the field of drug discovery. In this study we aimed to produce a new updated assay for the discovery of biosynthetic gene
Gregory C A Amos, Chiara Borsetto, Paris Laskaris, Martin Krsek, Andrew E Berry, Kevin K Newsham, Leo Calvo-Bado, David A Pearce, Carlos Vallin, Elizabeth M H Wellington   +9 more
doaj   +1 more source

Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering. [PDF]

PLoS ONE, 2016
Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) each give rise to a vast array of complex bioactive molecules with further complexity added by the existence of natural PKS-NRPS fusions.
Maria Lund Nielsen, Thomas Isbrandt, Lene Maj Petersen, Uffe Hasbro Mortensen, Mikael Rørdam Andersen, Jakob Blæsbjerg Hoof, Thomas Ostenfeld Larsen   +6 more
doaj   +1 more source

How Does China’s New Rural Pension Scheme Affect Agricultural Production?

Agriculture, 2022
This study examines the spillover effects of China’s New Rural Pension Scheme (NRPS) implemented in 2009 as a cash transfer program for agricultural production.
Xing Ji, Jingwen Xu, Hongxiao Zhang
doaj   +1 more source