Results 31 to 40 of about 11,489 (200)
Frontiers in Microbiology, 2018 Polyketides (PKs) and nonribosomal peptides (NRPs) are widely applied as drugs in use today, and one potential source for novel PKs and NRPs is the marine sediment microbes.
Yongjun Wei +3 more
doaj +1 more source
Lincosamide synthetase--a unique condensation system combining elements of nonribosomal peptide synthetase and mycothiol metabolism. [PDF]
PLoS ONE, 2015 In the biosynthesis of lincosamide antibiotics lincomycin and celesticetin, the amino acid and amino sugar units are linked by an amide bond. The respective condensing enzyme lincosamide synthetase (LS) is expected to be an unusual system combining ...
Jiri Janata +11 more
doaj +1 more source
Unified NRP-Modelling of Be Stars [PDF]
International Astronomical Union Colloquium, 2002 AbstractRecently, the line profile variability (lpv) of two low-v sin i Be stars, μ Cen and ω (28) CMa was successfully modelled as nonradial pulsation (nrp) of rapidly rotating stars seen pole-on. In this work, it is shown that the lpv of low-v sin i early-type Be stars in general closely resembles these two cases, and is therefore explainable by the ...
Th. Rivinius +3 more
openaire +1 more source
Nature Communications, 2019 The antimicrobial β-lactone obafluorin is produced by a Nonribosomal Peptide Synthetase (NRPS). Here the authors present the crystal structure of the obafluorin NRPS and develop a reconstitution assay that allows them to analyse product formation from ...
Dale F. Kreitler +4 more
doaj +1 more source
Nerpa: A Tool for Discovering Biosynthetic Gene Clusters of Bacterial Nonribosomal Peptides
Metabolites, 2021 Microbial natural products are a major source of bioactive compounds for drug discovery. Among these molecules, nonribosomal peptides (NRPs) represent a diverse class of natural products that include antibiotics, immunosuppressants, and anticancer agents.
Olga Kunyavskaya +7 more
doaj +1 more source
Advanced Science, EarlyView.A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa +8 more
wiley +1 more source
Kluster Gen Biosintetik (NRPS/PKS) Pada Bakteri Sedimen Mangrove Pantai Tirang Semarang Indonesia
Jurnal Kelautan TropisThis study aims to explore biosynthetic gene clusters and antibacterial activity in mangrove sediment bacteria at Tirang Beach, Semarang, Central Java. Research methods include isolating bacteria from seagrass sediments, antibacterial testing against S ...
Barra Muzaffar Widayat +2 more
doaj +1 more source
An Engineered Synthetic Pathway for Discovering Nonnatural Nonribosomal Peptides in
mBio, 2017 Peptides that are synthesized independently of the ribosome in plants, fungi, and bacteria can have clinically relevant anticancer, antihemochromatosis, and antiviral activities, among many other.
Sara Cleto, Timothy K. Lu
doaj +1 more source
Advanced Science, EarlyView.This study uses tyrosinase, which is highly expressed in melanoma, to drive porphyrins to polymerize and self‐assemble within tumor cells to form retented microstructures. This process induces immunogenic death and activates immune responses (M1 macrophages, dendritic cells, CD8+T cells), turning “cold” tumors into “hot” tumors.
Mian Tang +9 more
wiley +1 more source
Frontiers in Public Health, 2023 At present, China has become one of the fastest growing countries in terms of junk food consumption. However, there has been less previous evidence for the effect of endowment insurance on dietary health.
Shi Purun +3 more
doaj +1 more source