Results 31 to 40 of about 14,800 (259)
Expression and purification of an adenylation domain from a eukaryotic nonribosomal peptide synthetase: Using structural genomics tools for a challenging target [PDF]
, 2010 Nonribosomal peptide synthetases (NRPSs) are large multimodular and multidomain enzymes that are involved in synthesising an array of molecules that are important in human and animal health.
Lee, TV +11 more
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Demonstration on the result panel of the NRPS Motif Finder. [PDF]
, 2023 The NRPS Motif Finder result panel provides an interactive interface. The whole result could be navigated by scrolling the page, and details about motif and intermotif could be viewed by clicking the corresponding components.
Chen Song (216175) +7 more
core +1 more source
Neonatal resuscitation: the NRP guidelines [PDF]
Canadian Journal of Anaesthesia, 1994 The Neonatal Resuscitation Programme, sponsored by the Canadian Heart and Stroke Foundation and by the American Heart Association, is a structured learning package and workshop for all individuals who provide resuscitation for newborns. The emphasis is on rapid, decisive action using algorithms based on clearly stated criteria.
openaire +2 more sources
NRPS Substrate Promiscuity Diversifies the Xenematides [PDF]
, 2015 Xenematide, a cyclic depsipeptide antibiotic produced by Xenorhabdus nematophila, had a candidate nonribosomal peptide synthetase (NRPS) with atypical features.
Jason M. Crawford (1280400) +4 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2019 The argyrins are secondary metabolites from myxobacteria with antibiotic activity against Pseudomonas aeruginosa. Studying their structure–activity relationship is hampered by the complexity of the chemical total synthesis.
David C. B. Siebert +6 more
doaj +1 more source
Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery
Nature Communications, 2021 Current genome mining methods predict many putative non-ribosomal peptides (NRPs) from their corresponding biosynthetic gene clusters, but it remains unclear which of those exist in nature and how to identify their post-assembly modifications.
Bahar Behsaz +15 more
doaj +1 more source
High-throughput reprogramming of an NRPS condensation domain
Nature Chemical Biology, 2023 Abstract Engineered biosynthetic assembly lines could revolutionize the sustainable production of bioactive natural product analogs. Although yeast display is a proven, powerful tool for altering the substrate specificity of gatekeeper adenylation domains in nonribosomal peptide synthetases (NRPSs), comparable strategies for other ...
Ines B. Folger +6 more
openaire +4 more sources
Indonesian Journal of Biotechnology, 2015 Marine actinomycetes is a group of bacteria that is highly potential in producing novel bioactive compound. It has unique characteristics and is different from other terrestrial ones.
Camelia Herdini +8 more
doaj +1 more source
Neuropilin (NRPs) Related Pathological Conditions and Their Modulators
International Journal of Molecular Sciences, 2022 Neuropilin 1 (NRP1) represents one of the two homologous neuropilins (NRP, splice variants of neuropilin 2 are the other) found in all vertebrates. It forms a transmembrane glycoprotein distributed in many human body tissues as a (co)receptor for a variety of different ligands.
Matic Broz +3 more
openaire +4 more sources
Impact of pension income on healthcare utilization of older adults in rural China
International Journal for Equity in Health, 2023 Objective In China, rural residents experience poorer health conditions and a higher disease burden compared to urban residents but have lower healthcare services utilization. Rather than an insurance focus on enhanced healthcare services utilization, we
Peizhe Yan +6 more
doaj +1 more source