Results 51 to 60 of about 14,800 (259)

Unified NRP-Modelling of Be Stars [PDF]

International Astronomical Union Colloquium, 2002
AbstractRecently, the line profile variability (lpv) of two low-v sin i Be stars, μ Cen and ω (28) CMa was successfully modelled as nonradial pulsation (nrp) of rapidly rotating stars seen pole-on. In this work, it is shown that the lpv of low-v sin i early-type Be stars in general closely resembles these two cases, and is therefore explainable by the ...
Th. Rivinius, D. Baade, S. Štefl, M. Maintz   +3 more
openaire   +1 more source

Three NRPS or NRPS/PKS-type biosynthetic gene clusters from the Moorea producens JHB genome, annotated by antiSMASH for predicted products. [PDF]

, 2015
Three NRPS or NRPS/PKS-type biosynthetic gene clusters from the Moorea producens JHB genome, annotated by antiSMASH for predicted products.
Suneet Mehrotra (776848), Paul D. Boudreau (776846), Shane Desfor (776849), Lena Gerwick (224905), Emily A. Monroe (776847), Anton Korobeynikov (514713), William H. Gerwick (176359), David H. Sherman (46395), Pieter C. Dorrestein (224907), Thomas F. Murray (776850)   +9 more
core   +1 more source

Discovery and Characterization of a PKS–NRPS Hybrid in Aspergillus terreus by Genome Mining [PDF]

, 2020
Fungal polyketide synthase–nonribosomal peptide synthetase (PKS–NRPS) hybrids have been characterized to produce polyketide–amino acid compounds with striking structural features and biological activities.
Xuenian Huang, Wei Zhang, Wei Zhang (405), Xuefeng Lu, Ce Geng, Hongcheng Li (6869378), Hongcheng Li, Ce Geng (5798762), Shen Tang, Zhimin Li, Xuenian Huang (6503471), Zhimin Li (367035), Xuefeng Lu (220197), Shen Tang (6496067)   +13 more
core   +1 more source

A Wagner–Meerwein‐Like Rearrangement Generates a Vinyl Group in the Biosynthesis of the Polychlorinated Lipopeptides Fischerazoles

Angewandte Chemie, EarlyView.
The fischerazoles, unusual cyanobacterial chlorinated lipopeptides are reported. During their biosynthesis, a linear fatty acyl‐acyl carrier protein (ACP) precursor is rearranged through the action of the S‐adenosyl‐methionine (SAM)‐dependent methyltransferase FshF, to generate a pendant vinyl group.
Sandra A. C. Figueiredo, Kathleen Abt, Konrad Viehrig, Peter J. Jervis, Teresa P. Martins, Iñaki Lacomba, Chuhan Li, Daniele Castagnolo, Pedro N. Leão   +8 more
wiley   +2 more sources

Diversity of Gene Clusters for Polyketide and Nonribosomal Peptide Biosynthesis Revealed by Metagenomic Analysis of the Yellow Sea Sediment

Frontiers in Microbiology, 2018
Polyketides (PKs) and nonribosomal peptides (NRPs) are widely applied as drugs in use today, and one potential source for novel PKs and NRPs is the marine sediment microbes.
Yongjun Wei, Lei Zhang, Zhihua Zhou, Xing Yan   +3 more
doaj   +1 more source

Lincosamide synthetase--a unique condensation system combining elements of nonribosomal peptide synthetase and mycothiol metabolism. [PDF]

PLoS ONE, 2015
In the biosynthesis of lincosamide antibiotics lincomycin and celesticetin, the amino acid and amino sugar units are linked by an amide bond. The respective condensing enzyme lincosamide synthetase (LS) is expected to be an unusual system combining ...
Jiri Janata, Stanislav Kadlcik, Marketa Koberska, Dana Ulanova, Zdenek Kamenik, Petr Novak, Jan Kopecky, Jitka Novotna, Bojana Radojevic, Kamila Plhackova, Radek Gazak, Lucie Najmanova   +11 more
doaj   +1 more source

Genetic organization of P. larvae PKS/NRPS biosynthesis gene clusters. [PDF]

, 2014
Shown are the PKS/NRPS biosynthesis gene clusters from P. larvae DSM 25719 (ERIC I) and DSM 25430 (ERIC II) genes. Iturin family lipopeptide antibiotic NRPS/PKS cluster (A), gramicidin S synthase NRPS cluster (B), organization and architecture of a novel
Anne Fünfhaus (322850), Jörn Voss (531129), Lena Poppinga (322843), Kathleen Gollnow (409953), Elzbieta Brzuszkiewicz (199180), Eva Garcia-Gonzalez (322855), Marvin Djukic (531128), Elke Genersch (322863), Rolf Daniel (113374), Heiko Liesegang (243100)   +9 more
core   +1 more source

Prediction of NRPS domains from Pseudocercospora species. [PDF]

, 2021
For each species, the table indicates NRPS domains predicted by the program PKS/NRPS Analysis Web-site [43], the location of those domains within the predicted protein sequence, the residues within the adenylation domain(s), and the substrate prediction ...
Elizabeth Thomas (137168), Margaret E. Daub (8582103), Roslyn D. Noar (3158139)   +2 more
core   +1 more source

Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl‐Substituted, α‐Oxidized γ‐Amino Acids

Angewandte Chemie, EarlyView.
Genome mining of atypical condensation (C) domains leads to the discovery of myxoglucamides, glycolipopeptides featuring an unprecedented vinyl‐substituted, α‐oxidized γ‐amino acid. Biosynthetic studies reveal a discrete C‐domain‐like O‐acyltransferase, a β‐hydroxylation‐dependent chain‐extension checkpoint, and an unusual pathway for γ‐amino acid ...
Tingting Wang, Alexander Popoff, Maja Hunter, Guangzhi Dai, Ronald Garcia, Huixin Xu, Haowen Zhao, Asfandyar Sikandar, Liujie Huo, Rolf Müller, Chengzhang Fu   +10 more
wiley   +2 more sources

Nerpa: A Tool for Discovering Biosynthetic Gene Clusters of Bacterial Nonribosomal Peptides

Metabolites, 2021
Microbial natural products are a major source of bioactive compounds for drug discovery. Among these molecules, nonribosomal peptides (NRPs) represent a diverse class of natural products that include antibiotics, immunosuppressants, and anticancer agents.
Olga Kunyavskaya, Azat M. Tagirdzhanov, Andrés Mauricio Caraballo-Rodríguez, Louis-Félix Nothias, Pieter C. Dorrestein, Anton Korobeynikov, Hosein Mohimani, Alexey Gurevich   +7 more
doaj   +1 more source