Results 51 to 60 of about 11,489 (200)
Toxins, 2020 Prokaryotes represent a source of both biotechnological and pharmaceutical molecules of importance, such as nonribosomal peptides (NRPs). NRPs are secondary metabolites which their synthesis is independent of ribosomes.
Mario Alberto Martínez-Núñez +1 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.Chemoenzymatic reactions using the siderophore synthetase DesD from Salinispora tropica and hydroxamic acid substrates (native, non‐native) with different multiplicities (monomer, dimer) and components (homo‐/heterodimer) followed different reaction trajectories, which biased the architectures of the chelator major products and indicated DesD contains ...
Callum A. Rosser +2 more
wiley +1 more source
Improved Incorporation of Arylglycines Into Ramoplanin Sequences via Solid‐Phase Peptide Synthesis
European Journal of Organic Chemistry, EarlyView.The incorporation of arylglycines using solid‐phase peptide synthesis remains challenging due to the sensitivity of these residues for epimerization. Here, exploring multiple conditions for the incorporation of arylglycine residues into peptides using SPPS demonstrates how small changes to current synthesis protocols can lead to significant ...
Edward Marschall +3 more
wiley +1 more source
Diversity of Nonribosomal Peptide Synthetase Genes in the Microbial Metagenomes of Marine Sponges
Marine Drugs, 2012 Genomic mining revealed one major nonribosomal peptide synthetase (NRPS) phylogenetic cluster in 12 marine sponge species, one ascidian, an actinobacterial isolate and seawater.
Ute Hentschel +3 more
doaj +1 more source
Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications
Journal of the Chinese Chemical Society, EarlyView.This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley +1 more source
Combination Methods for Screening Marine Actinomycetes Producing Potential Compounds as Anticancer
Indonesian Journal of Biotechnology, 2007 Marine actinomycetes is a robust source of secondary metabolites including anticancer compounds . The objective of this research was to select marine actinomycetes producing potential compounds as anticancer used combination methods that consist of ...
Yuyun Farida, Jaka Widada, Edy Meiyanto
doaj +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley +1 more source
PCR-based Screening Approach: A Rapid Method to Detect the Biosynthetic Potential of Antimicrobials in Actinobacterial Strains [PDF]
Polish Journal of Microbiology, 2020 NAILA NOUREEN +4 more
doaj +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Field inoculation with arbuscular mycorrhizal fungi (AMF) offers a promising route to improve sustainable agriculture and food production, yet results are often variable. We investigated the mycorrhizal growth response of maize and wheat varieties recommended for farmers and found substantial variation under greenhouse conditions.
Ido Rog +5 more
wiley +1 more source
A hybrid NRPS-PKS gene cluster related to the bleomycin family of antitumor antibiotics in Alteromonas macleodii strains. [PDF]
PLoS ONE, 2013 Although numerous marine bacteria are known to produce antibiotics via hybrid NRPS-PKS gene clusters, none have been previously described in an Alteromonas species.
Carolina Megumi Mizuno +5 more
doaj +1 more source