Results 61 to 70 of about 14,800 (259)
Advanced Science, EarlyView.The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen +9 more
wiley +1 more source
Distribution of NRPS gene families within the Neotyphodium/Epichloe complex [PDF]
, 2007 Neotyphodium and Epichloë spp are closely related asexual and sexual endophytic fungi, respectively, that form mutualistic associations with cool season grasses of the subfamily Pooideae.
Pratt, J +6 more
core +1 more source
Kluster Gen Biosintetik (NRPS/PKS) Pada Bakteri Sedimen Mangrove Pantai Tirang Semarang Indonesia
Jurnal Kelautan TropisThis study aims to explore biosynthetic gene clusters and antibacterial activity in mangrove sediment bacteria at Tirang Beach, Semarang, Central Java. Research methods include isolating bacteria from seagrass sediments, antibacterial testing against S ...
Barra Muzaffar Widayat +2 more
doaj +1 more source
Nature Communications, 2019 The antimicrobial β-lactone obafluorin is produced by a Nonribosomal Peptide Synthetase (NRPS). Here the authors present the crystal structure of the obafluorin NRPS and develop a reconstitution assay that allows them to analyse product formation from ...
Dale F. Kreitler +4 more
doaj +1 more source
An Engineered Synthetic Pathway for Discovering Nonnatural Nonribosomal Peptides in
mBio, 2017 Peptides that are synthesized independently of the ribosome in plants, fungi, and bacteria can have clinically relevant anticancer, antihemochromatosis, and antiviral activities, among many other.
Sara Cleto, Timothy K. Lu
doaj +1 more source
Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma
Advanced Science, EarlyView.ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba +25 more
wiley +1 more source
Reconstruction of the PKS/NRPS genes and gene clusters. [PDF]
, 2013 HSP, high-scoring segment pair; NRPS, nonribosomal peptide synthetase; PKS, polyketide synthase.The open circles denote that the gene continuity of genes in each corresponding cluster is reproduced.aThe PKS/NRPS genes are listed in Table S2.
Myco Umemura (410319) +6 more
core +1 more source
Frontiers in Public Health, 2023 At present, China has become one of the fastest growing countries in terms of junk food consumption. However, there has been less previous evidence for the effect of endowment insurance on dietary health.
Shi Purun +3 more
doaj +1 more source
On the ethics of NRP and the American College of Physicians NRP statement [PDF]
American Journal of Transplantation, 2022 Isaac O, Opole +2 more
openaire +2 more sources
Artificial Host‐Guest Recognition Directs Glycometabolically Engineered Macrophages to Tumors
Advanced Science, EarlyView.Glycoengineered supramolecular macrophages (GSAR‐M) are developed using glycometabolic labeling for bioorthogonal host‐guest tumor targeting. This engineering approach unexpectedly enhances macrophage migration, phagocytosis, and pseudopodia formation. Consequently, GSAR‐M demonstrate robust tumor‐targeting specificity, effectively arrest tumor growth,
Zhiqing Yang +8 more
wiley +1 more source