Results 81 to 90 of about 11,489 (200)
ABSTRACT Across the Western world, joint legal and physical custody is increasingly becoming the default post‐separation arrangement. While family policy and law encourage such arrangements, they may not suit every situation. In child‐custody court disputes, courts must consider whether sole legal custody is the best alternative for the child in each ...
Johanna Finnström, Ann‐Zofie Duvander
wiley +1 more source
Outcomes after resection of pancreatic ductal adenocarcinoma remain highly variable, and existing prognostic models lack sufficient accuracy. Here, the authors aimed to improve survival prediction by integrating transcriptome‐based subtyping into a validated clinical model and applying it to a multicenter real‐world cohort of fresh‐frozen resection ...
Marjolein F. Lansbergen +20 more
wiley +1 more source
ClusterMine360: a database of microbial PKS/NRPS biosynthesis
ClusterMine360 (http://www.clustermine360.ca/) is a database of microbial polyketide and non-ribosomal peptide gene clusters. It takes advantage of crowd-sourcing by allowing members of the community to make contributions while automation is used to help achieve high data consistency and quality.
Kyle R. Conway, Christopher N. Boddy
openaire +3 more sources
3,3′,4,5′‐Tetramethoxy‐trans‐stilbene alleviates hepatic insulin resistance and metabolic dysfunction‐associated steatotic liver disease, through the activation of IRS/PI3K/Akt/GSK3β/GS and Nrf2/HO‐1 pathways, in diet‐induced obese mice. The figure was created with MedPeer (medpeer.cn).
Qiaowen Deng +6 more
wiley +1 more source
Mutasynthesis and Antibiotic Activity of Mupirocin Analogues
A mutasynthetic strategy was developed to prepare pseudomonic acid analogues, and their antimicrobial activities were evaluated against five bacterial strains. Feeding studies with mutant strains of Pseudomonas fluorescens revealed that C7‐desepoxy‐PA‐B was metabolised to C7‐PA‐C with loss of the 8‐hydroxyl group, but no fatty acid chain extension ...
Sarah M. Husain +11 more
wiley +1 more source
Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
Modifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity.
Takayoshi Awakawa +10 more
doaj +1 more source
Multiple environmental DNA (eDNA) methods were compared with each other and with fyke netting for detecting invasive brown bullhead catfish. eDNA sampling combined with catfish‐specific metabarcoding provides sensitive detection and effectively complements traditional netting for biosecurity.
Nicola Rose Pyper +2 more
wiley +1 more source
The decades-long gap in antibiotic discovery has led to a significant health crisis due to antimicrobial resistance (AMR). The bacterial genus Xenorhabdus, which forms symbiotic relationships with the soil nematode Steinernema, are known to secrete a ...
Ritisha Dey +9 more
doaj +1 more source
Priority Actions for the Conservation of Primary and Old‐Growth Forests in Europe
ABSTRACT Primary and old‐growth forests are important for nature and society. Although global commitments to their conservation are increasing and the EU has aligned itself with these efforts, these forests remain critically threatened. Consequently, to meet its own targets rooted in global commitments, the EU needs a strategy that ensures their ...
Lyla O'Brien +11 more
wiley +1 more source
ABSTRACT Aim To summarise the effect of mentoring within mentoring programmes on the retention and turnover of newly graduated nurses in healthcare settings. Design An umbrella review. Methods Two independent reviewers screened the titles, abstracts and full texts for eligibility and critically appraised the included reviews using the JBI critical ...
Elina Södergård +4 more
wiley +1 more source

