Results 81 to 90 of about 11,913 (171)
The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu +2 more
wiley +1 more source
Combination Methods for Screening Marine Actinomycetes Producing Potential Compounds as Anticancer
Marine actinomycetes is a robust source of secondary metabolites including anticancer compounds . The objective of this research was to select marine actinomycetes producing potential compounds as anticancer used combination methods that consist of ...
Yuyun Farida, Jaka Widada, Edy Meiyanto
doaj
Abstract Background Peri‐implantitis is a biofilm‐associated inflammatory condition characterized by peri‐implant mucosal inflammation and progressive bone loss. The prevalence of peri‐implantitis continues to rise among patients with dental implants. Although peri‐implantitis and periodontitis share similar inflammatory phenotypes, histopathological ...
Yumeng Yan +2 more
wiley +1 more source
ABSTRACT Across the Western world, joint legal and physical custody is increasingly becoming the default post‐separation arrangement. While family policy and law encourage such arrangements, they may not suit every situation. In child‐custody court disputes, courts must consider whether sole legal custody is the best alternative for the child in each ...
Johanna Finnström, Ann‐Zofie Duvander
wiley +1 more source
Slow Infrastructural Violence: The Lived Experiences of Urban Essential Workers
Abstract We examine how non‐healthcare urban essential workers constitute a vital yet undervalued social infrastructure that enables everyday life in Switzerland. Drawing on 37 (walking) interviews, the study foregrounds the lived realities of those whose reproductive labour sustains the city while remaining largely invisible.
Carole Ammann, Sarah Schilliger
wiley +1 more source
Using Texts as Megaphones: The Power of African American Readers Hearing Themselves in Books
ABSTRACT This article highlights the power of authentic children's literature to affirm African American English as a legitimate, rule‐governed linguistic system and elevate it as a source of cognitive strength, cultural richness, and academic potential.
Ramona T. Pittman +3 more
wiley +1 more source
Limbal cystotomy by fine needle aspiration of a translucent iris cyst in a horse
Summary A 4‐year‐old Cremello crossbred mare was referred to the Equine Veterinary Teaching Hospital of Utrecht University for a translucent iris cyst from the dorsal pupillary margin corpora nigra in the right eye. Although noninvasive diode laser treatment is the preferred method of pigmented cyst ablation, two attempts did not result in disruption ...
A. L. Hendrikx +5 more
wiley +1 more source
Predicting Functional Diversity Within Enzyme Families: A Practical Perspective
Integrating machine learning into enzyme discovery requires navigating the trade‐offs between data quantity and quality. This article provides a best‐practice framework for developing robust predictors, focusing on mitigating bias in biochemical datasets, implementing systematic “cold‐drug” validation strategies, and utilizing explainable artificial ...
Nika Sokolova, Kristina Haslinger
wiley +1 more source
Pyoverdines are high affinity siderophores produced by most Pseudomonas with a wide role in microbial interspecies interactions. They are primarily composed of a conserved chromophore moiety, an acyl side chain and a peptide backbone which may be highly ...
Lucía Graña-Miraglia +5 more
doaj +1 more source
Deconstruction of Human Age‐Related Cataract Capsules Defines Aging
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang +9 more
wiley +1 more source

