Results 91 to 100 of about 11,913 (171)

Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform

Advanced Science, Volume 13, Issue 56, 9 October 2026.
Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao, Cang‐Man Zhang, Ru‐Jie Yang, Min Ren, Zhuo‐Ling Zhong, Kang‐Hui Wang, Rui‐Xue Hu, Jia‐Yue Liu, Jun‐Yi Zhou, Hou‐Kai Li, Jian‐Bo Wan   +10 more
wiley   +1 more source

Actinomycin Analogs From Streptomyces polyantibioticus S4D258: Structural Elucidation and Antiproliferative Activity Against Triple‐Negative Breast Cancer

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Fifteen new actinomycin analogs, named actinomycins H1–H15, are identified from S. polyantibioticus S4D258. Actinomycins H7–H15 are truncated actinomycin analogs. Actinomycins H1–H6 and H9 exhibit significant antiproliferative activities against both MDA‐MB‐231 and 4T1 TNBC cells.
He Pang, Xiao‐Min Huang, Usama Ramadan Abdelmohsen, Li Shen, Jun Wu   +4 more
wiley   +1 more source

Non-magnetic four-port electronic circulators based on $$90^\circ $$ 90 ∘ non-reciprocal phase-shifters

Scientific Reports
This paper presents a family of four-port electronic circulators adhering to a new topology symmetry that enables linear, low-loss transistor-based circuit implementations. The underlying principle of operation employs a property of the $$90^\circ $$ 90 ∘
Dror Regev, Shaked Regev, Shimi Shilo, Doron Ezri, Nimrod Ginzberg, Emanuel Cohen   +5 more
doaj   +1 more source

Receptor‐Targeted Niosomal Nanocarriers: Advances, Challenges, and Opportunities in Natural Compound Delivery for Cancer Therapy

Nano Select, Volume 7, Issue 10, October 2026.
Surface‐modified niosomes are introduced as multifunctional nanoparticles for precision tumor treatment that combine hydrophilic and lipophilic drug encapsulation with ligand‐based targeting via antibodies, peptides, transferrin, and folic acid. This modification leads to increased tumor selectivity, facilitates cell entry, and enables enhanced ...
Narges Sahraei, Aryan M. Faraj, Faezeh Molaei, Abolfazl Barzegar   +3 more
wiley   +1 more source

DNA Origami Uptake in Y‐79 Retinoblastoma Cells Driven by Oligolysine Coating

Small Structures, Volume 7, Issue 10, October 2026.
We show that polymeric coating can enable DNA origami nanoparticle internalization into ocular retinoblastoma cells. Not only are the coated nanoparticles well‐tolerable to the cells, but they also remain mobile in the vitreous of a porcine ex vivo model.
Anna Klose, Zahra Gounani, Sergei Raik, Artturi Koivuniemi, Sonja Korhonen, Mika Reinisalo, Tatu Lajunen, Veikko Linko, Timo Laaksonen   +8 more
wiley   +1 more source

Structural and Functional Siderophore Remodeling by Enzymatic Delipidation

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog, Keishi Ishida, Evelyn M. Molloy, Ron Hermenau, Kirstin Scherlach, Christian Hertweck   +5 more
wiley   +2 more sources

Cyanopeptide Mixtures Induce Variable Synergistic and Antagonistic Effects Across Diverse Human Cell Lines

Environmental Toxicology, Volume 41, Issue 10, Page 807-821, October 2026.
ABSTRACT Cyanobacterial harmful algal blooms (cyanoHABs) threaten human, animal, and ecosystem health and safety through production of toxic secondary metabolites. Microcystis, a cosmopolitan bloom‐forming cyanobacterial genus, is well‐known for producing hepatotoxic microcystins (MCs), but it can produce many other bioactive cyanopeptides, such as ...
Lauren N. Hart, Katherine L. Lev, Sierra Hefferan, Sanduni H. Premathilaka, Sharmila I. Thenuwara, Dragan Isailovic, David H. Sherman, Gregory J. Dick   +7 more
wiley   +1 more source

Genomic and Phenotypic Classification of Staphylococcus Species Isolated From Delhi Air

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
Multiple Staphylococcus spp. were isolated from the outdoor polluted air of the Indian Capital, New Delhi. The bacterial samples were collected from 6 different locations, and the whole genome of four Staphylococcus isolates was sequenced in their entirety. This study presents the comparative genomic analysis of these four isolates.
Himanshu Sen, Joyasree Das, Suman Paul, Manpreet Kaur, Amareshwar Vodapalli, Surajit Bhattacharjee, Manoj Raje, Srinivasan Krishnamurthi, Saumya Raychaudhuri   +8 more
wiley   +1 more source

When Machine Perfusion Falls Short: Identifying Risks of Liver Graft Failure After Normothermic Machine Perfusion

Artificial Organs, Volume 50, Issue 10, Page 1407-1417, October 2026.
Analysis of 4928 normothermic machine perfusion liver transplants reveals that recipient factors, particularly MELD ≥ 35, surgical complexity, ICU status, and functional impairment are stronger predictors of graft failure than donor characteristics, emphasizing the continued importance of clinical judgment in patient selection.
Lauren E. Matevish, Abdullah K. Malik, Milana Harris, Ahmad Anouti, Taylor M. Coe, Simon Moosburner, Nathanael Raschzok, Arjmand Mufti, Parsia A. Vagefi, Madhukar S. Patel   +9 more
wiley   +1 more source

A Multi‐Scale Computational Framework for Anti‐Persister Tuberculosis Drug Discovery

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
This review presents an integrated QSAR–scaffold design–docking–MD framework for discovering anti‐persister tuberculosis agents active in dormant granuloma‐like conditions. By targeting Mtb bioenergetics and prioritising dual NDH‐2/cytochrome bd oxidase inhibition, the workflow advances rational design of candidates with higher resistance barriers ...
Said Moshawih, Anguraj Moulishankar, Chee Yan Choo, Khang Wen Goh, Chrismawan Ardianto, Azam Che Idris, Long Chiau Ming   +6 more
wiley   +1 more source