Results 111 to 120 of about 14,800 (259)

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source

Liquid‐Processed 2D Aromatic Amorphous Carbon: Defect Engineering and Universal Transport Scaling

Small, EarlyView.
Liquid‐processed graphene oxide (GO) thin films undergo a controllable crystalline–to–amorphous transition driven by thermal quenching. By kinetically tuning oxygen‐driven defect formation during reduction, scalable 2D aromatic amorphous carbon phases are stabilized, directly linking nanoscale disorder and defect topology to electronic transport ...
Fabiola Liscio, Andrea Fondacaro, Gaetana Petrone, Federico Chianese, Jasper Rikkert Plaisier, Sara Fiori, Orlando Castellano, Alice Apponi, Nicolò Galvani, Verónica Montes García, Veronica Valentini, Stefano Iacobucci, Damiano Ricciarelli, Giuseppe Fisicaro, Antonino Lamagna, Giovanni Maria Vinai, Ernesto Placidi, Alessandro Bellucci, Daniele Maria Trucchi, Paolo Samorì, Alessandro Ruocco, Samuel Lara Avila, Andrea Liscio   +22 more
wiley   +1 more source

Cyanopeptide Mixtures Induce Variable Synergistic and Antagonistic Effects Across Diverse Human Cell Lines

Environmental Toxicology, EarlyView.
ABSTRACT Cyanobacterial harmful algal blooms (cyanoHABs) threaten human, animal, and ecosystem health and safety through production of toxic secondary metabolites. Microcystis, a cosmopolitan bloom‐forming cyanobacterial genus, is well‐known for producing hepatotoxic microcystins (MCs), but it can produce many other bioactive cyanopeptides, such as ...
Lauren N. Hart, Katherine L. Lev, Sierra Hefferan, Sanduni H. Premathilaka, Sharmila I. Thenuwara, Dragan Isailovic, David H. Sherman, Gregory J. Dick   +7 more
wiley   +1 more source

EKSPLORASI GEN NRPS (NONRIBOSOMAL PEPTIDE SYNTHETASE) DARI BAKTERI ENDOFIT PADA AKAR TUMBUHAN OBAT: Ageratum conyzoides L. DAN Vetiveria zizanioides L. [PDF]

, 2015
Studi mengenai keragaman gen nonribosomal peptide synthetase (NRPS) pada isolat bakteri endofit akar tumbuhan obat Vetiveria zizanioides dan Ageratum conyzoides telah dilakukan.
Herdiansyah, Sandy Ahmad
core  

A rational multi-target combination strategy for synergistic improvement of non-ribosomal peptide production

Nature Communications
Non-ribosomal peptides (NRPs) are pharmaceutically important natural products that include numerous clinical drugs. However, the biosynthesis of these NRPs is intricately regulated and improving production through manipulation of multiple regulatory ...
Hao Yan, Zhenguo Xin, Ziwei Sang, Xingwang Li, Jia Xie, Jiale Wu, Shen Pang, Ying Wen, Weishan Wang   +8 more
doaj   +1 more source

Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cocaine use disorder (CUD) is an increasingly widespread concern worldwide. Various pharmacological treatments have been investigated for CUD, but their efficacy remains unclear, and none have been licensed for treatment.
Craig Paterson, Thomas Parkhouse, Chloe Burke, Monika Halicka, Jennifer C. Palmer, Hend Gabr, Rebecca Wilson, Katie E. Webster, Francesca Spiga, Sarah Dawson, Deborah M. Caldwell, Jennifer Scott, Julian P. T. Higgins, Jelena Savović   +13 more
wiley   +1 more source

When Machine Perfusion Falls Short: Identifying Risks of Liver Graft Failure After Normothermic Machine Perfusion

Artificial Organs, EarlyView.
Analysis of 4928 normothermic machine perfusion liver transplants reveals that recipient factors, particularly MELD ≥ 35, surgical complexity, ICU status, and functional impairment are stronger predictors of graft failure than donor characteristics, emphasizing the continued importance of clinical judgment in patient selection.
Lauren E. Matevish, Abdullah K. Malik, Milana Harris, Ahmad Anouti, Taylor M. Coe, Simon Moosburner, Nathanael Raschzok, Arjmand Mufti, Parsia A. Vagefi, Madhukar S. Patel   +9 more
wiley   +1 more source

Albicidin Pathotoxin Produced by Xanthomonas albilineans Is Encoded by Three Large PKS and NRPS Genes Present in a Gene Cluster Also Containing Several Putative Modifying, Regulatory, and Resistance Genes

Molecular Plant-Microbe Interactions, 2004
Xanthomonas albilineans, which causes leaf scald disease of sugarcane, produces a highly potent pathotoxin called albicidin. We report here sequencing and homology analysis of the major gene cluster, XALB1 (55,839 bp), and a second, smaller region, XALB2
Monique Royer, Laurent Costet, Eric Vivien, Martine Bes, Arnaud Cousin, Anne Damais, Isabelle Pieretti, Alexandre Savin, Sandrine Megessier, Magali Viard, Roger Frutos, Dean W. Gabriel, Philippe C. Rott   +12 more
doaj   +1 more source

ClusterMine360: a database of microbial PKS/NRPS biosynthesis

Nucleic Acids Research, 2012
ClusterMine360 (http://www.clustermine360.ca/) is a database of microbial polyketide and non-ribosomal peptide gene clusters. It takes advantage of crowd-sourcing by allowing members of the community to make contributions while automation is used to help achieve high data consistency and quality.
Kyle R. Conway, Christopher N. Boddy
openaire   +3 more sources

Death Determination, the Dying Process and the Dead Donor Rule: A Critical Analysis of the Italian 20‐Minute No‐Touch Period in Controlled Donation After Circulatory Determination of Death

Bioethics, EarlyView.
ABSTRACT In Italy, controlled Donation after Circulatory Determination of Death (cDCDD) requires a 20‐min no‐touch period documented by continuous electrocardiographic monitoring. Since Italian law adopts a single brain‐based definition of death, this procedure serves as an indirect determination of the irreversible cessation of all brain functions ...
Lucia Craxì
wiley   +1 more source