Results 121 to 130 of about 14,800 (259)

How Effective Are Ireland's Monitory Mechanisms in Improving Its Child Protection and Welfare Services?

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT Child protection and welfare systems are entrusted with significant power by governments and are therefore a significant focus of monitoring activities. Monitoring can help to build a better child protection system and to ensure child safety; track policy and legislative implementation and resource allocation; contribute to preventing systemic
Kenneth Burns   +3 more
wiley   +1 more source

Quorum sensing regulators and non-ribosomal peptide synthetases govern antibacterial secretions in Xenorhabdus szentirmaii

open access: yesFrontiers in Microbiology
The decades-long gap in antibiotic discovery has led to a significant health crisis due to antimicrobial resistance (AMR). The bacterial genus Xenorhabdus, which forms symbiotic relationships with the soil nematode Steinernema, are known to secrete a ...
Ritisha Dey   +9 more
doaj   +1 more source

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

open access: yesNature Communications, 2018
Modifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity.
Takayoshi Awakawa   +10 more
doaj   +1 more source

Limbal cystotomy by fine needle aspiration of a translucent iris cyst in a horse

open access: yesEquine Veterinary Education, EarlyView.
Summary A 4‐year‐old Cremello crossbred mare was referred to the Equine Veterinary Teaching Hospital of Utrecht University for a translucent iris cyst from the dorsal pupillary margin corpora nigra in the right eye. Although noninvasive diode laser treatment is the preferred method of pigmented cyst ablation, two attempts did not result in disruption ...
A. L. Hendrikx   +5 more
wiley   +1 more source

Caffeylpyruvate hydrolase from the bioluminescent fungus Neonothopanus gardneri is the key recycling enzyme in the fungal bioluminescence pathway

open access: yesThe FEBS Journal, EarlyView.
Caffeic acid is a central metabolite in the fungal bioluminescence pathway. We identified and characterized caffeylpyruvate hydrolase from Neonothopanus gardneri (ngarCPH) and demonstrate its ability to hydrolyze fungal oxyluciferin into caffeic and pyruvic acids, confirming a complete and self‐sustained fungal bioluminescence cycle.
Caio K. Zamuner   +8 more
wiley   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

open access: yesThe FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu   +2 more
wiley   +1 more source

The (Un)deserving Parent: Exploring Parental Argumentation and Sole‐Custody Decisions in Swedish Courts

open access: yesSocial Policy &Administration, EarlyView.
ABSTRACT Across the Western world, joint legal and physical custody is increasingly becoming the default post‐separation arrangement. While family policy and law encourage such arrangements, they may not suit every situation. In child‐custody court disputes, courts must consider whether sole legal custody is the best alternative for the child in each ...
Johanna Finnström, Ann‐Zofie Duvander
wiley   +1 more source

Combination Methods for Screening Marine Actinomycetes Producing Potential Compounds as Anticancer

open access: yesIndonesian Journal of Biotechnology, 2015
Marine actinomycetes is a robust source of secondary metabolites including anticancer compounds . The objective of this research was to select marine actinomycetes producing potential compounds as anticancer used combination methods that consist of ...
Yuyun Farida, Jaka Widada, Edy Meiyanto
doaj  

Transcriptome‐Based Classification of Resected Pancreatic Ductal Adenocarcinoma Enhances Prognostic Modelling Accuracy of Overall Survival Following Adjuvant Treatment

open access: yesInternational Journal of Cancer, Volume 159, Issue 5, Page 1322-1336, 1 September 2026.
Outcomes after resection of pancreatic ductal adenocarcinoma remain highly variable, and existing prognostic models lack sufficient accuracy. Here, the authors aimed to improve survival prediction by integrating transcriptome‐based subtyping into a validated clinical model and applying it to a multicenter real‐world cohort of fresh‐frozen resection ...
Marjolein F. Lansbergen   +20 more
wiley   +1 more source

To NRP or Not to NRP, That Is the Question…

open access: yesTransplantation, 2019
John O O, Ayorinde   +2 more
openaire   +3 more sources

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