Results 101 to 110 of about 14,800 (259)
A new 3,6-dialkyl-α-pyrone produced by the heterologous expression of a PKS-NRPS hybrid enzyme derived from a Pestalotiopsis endophyte [PDF]
Genome mining of polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) hybrid enzymes independent of trans-acting enoyl reductase using our in-house fungal draft genomic library led to the discovery of a unique PKS-NRPS hybrid enzyme, PbpsA ...
Shi, Yue +9 more
core +1 more source
Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications
Journal of the Chinese Chemical Society, EarlyView.This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley +1 more source
Total syntheses of spirocyclic PKS-NRPS-based fungal metabolites [PDF]
, 2018 We present the isolations, the biosynthetic studies, the biological activities, and the comprehensive description of all reported total syntheses of spirocyclic PKS-NRPS-based fungal natural products.
Sunkyu Han, Deokhee Jo
core +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley +1 more source
The fertility effects of public pension: Evidence from the new rural pension scheme in China.
PLoS ONE, 2020 Public pension insurance has become a major form of social protection around the world. However, little is known about the association between public pension expansion and individuals' fertility in developing economies.
Zheng Shen, Xiaodong Zheng, Hualei Yang
doaj +1 more source
Additional file 9: Figure S1 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli [PDF]
, 2019 Branch A from hybrid maximum likelihood phylogeny (Fig. 1). Sections and species groups indicated by tip color; Orientation of hybrids N-type (NRPS-PKS) and P-type (PKS-NRPS) indicated by tip shape.
Tammi Vesth (399962) +2 more
core +1 more source
Jack of many trades: Multifaceted role of neuropilins in pancreatic cancer
Cancer Medicine, 2018 Neuropilins (NRPs) have been described as receptors for class 3 semaphorins and coreceptors for a plethora of ligands, such as members of the vascular endothelial growth factor (VEGF) family of angiogenic cytokines and transforming growth factor (TGF ...
Pratiek N. Matkar +5 more
doaj +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Field inoculation with arbuscular mycorrhizal fungi (AMF) offers a promising route to improve sustainable agriculture and food production, yet results are often variable. We investigated the mycorrhizal growth response of maize and wheat varieties recommended for farmers and found substantial variation under greenhouse conditions.
Ido Rog +5 more
wiley +1 more source
Gene expression of the NRPS-PKS cluster. [PDF]
, 2013 The graph shows the estimated gene expression using RPKM values associated with the NRPS-PKS cluster of pAMDE1. Genes are colored according to the inferred function.
Nikole E. Kimes (460765) +5 more
core +1 more source