Results 101 to 110 of about 11,913 (171)

IMPROVE 2025: The 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence

Clinical Obesity, Volume 16, Issue 5, October 2026.
ABSTRACT An international cohort of 161 clinicians and researchers from 19 countries attended the 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence (IMPROVE) in Prague, Czech Republic, on 2–4 July 2025. The aims of the meeting were to advance understanding of hyperphagia and obesity caused by defects in the melanocortin‐4 receptor
Jesús Argente, Erica L. T. van den Akker, Metin Cetiner, Karine Clément, Elizabeth Forsythe, Alastair Garfield, Peter Kühnen, Gabriel Ángel Martos‐Moreno, David Meeker, Hermann L. Müller, Hanneke M. van Santen, Julia von Schnurbein, Bérénice Segrestin, Tomohiro Tanaka, Manuel Tena‐Sempere, Martin Wabitsch, Stefanie Zorn, I. Sadaf Farooqi   +17 more
wiley   +1 more source

Comparative Genomics Reveals Extensive Biosynthetic Diversity and Lineage-Specific Metabolic Potential Across <i>Talaromyces</i> Species. [PDF]

J Fungi (Basel)
Chellappan BV, Al-Sheikh H.
europepmc   +1 more source

Photoreactive Pantetheinyl Mimics Reveal Design Limitations for Crypto‐Acyl Carrier Proteins

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
Probes were rationally designed to capture key intramolecular interactions thorugh photocrosslinking in thiotemplated assembly lines: polyketide synthases (PKS), fatty acid synthases (FAS), and non‐ribosomal peptide synthetases (NRPS). Poor or no crosslinking was observed from these probes, highlighting current limitations of synthetic and structural ...
Anna‐Kay R. West, Tawakalitu A. Afolabi‐Balogun, Christian C. Martin, Lizbeth Cambron, Mujeeb A. Wakeel, Joshua A. Baccile, Constance B. Bailey   +6 more
wiley   +1 more source

A portable pathway specific transcription factor-promoter circuit enables heterologous production of fungal nonribosomal peptides. [PDF]

Chem Sci
Wei PL, Li Y, Ren Z, Zhang S, Ren J, Fan J, Yin WB.   +6 more
europepmc   +1 more source

Biosynthetic origin of anticancer dolastatin 15 reveals a noncanonical NRPS architecture enabling 2-keto acid activation. [PDF]

Proc Natl Acad Sci U S A
Chen M, Liu J, Tsai HY, Li CY, Batucan JD, Eckhardt CW, Pham THD, Ellis EK, Ratnayake R, Paul VJ, Bruner SD, Donia MS, Luesch H, Ding Y.   +13 more
europepmc   +1 more source

Single-cell chromatin profiling reveals relapse-related priming in pediatric acute myeloid leukemia. [PDF]

Life Sci Alliance
Cui B, Lei M, Liu L, Shu M, Yu F, Yang K, Pan Y, Song Y.   +7 more
europepmc   +1 more source

Synthesis of Glycopeptide Antibiotic Peptide Substrates Using Knorr‐Pyrazole Chemistry

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
The glycopeptide antibiotics (GPAs) are important clinical antibiotics. While chemoenzymatic synthesis of more hydrophilic GPAs like vancomycin has aided our understanding of GPA crosslinking, hydrophobic GPAs remain underexplored. Here, we show that modified Knorr‐pyrazole chemistry improves access to hydrophobic peptidyl‐CoAs, with such substrates ...
Jemma Gullick, W. Ramani H. Weerasinghe, Ralf B. Schittenhelm, Julien Tailhades, Max J. Cryle   +4 more
wiley   +1 more source

Draft genome sequence dataset of <i>Actinoalloteichus caeruleus</i> strain 372 isolated from saline soil in Kazakhstan: genomic features and predicted biosynthetic gene clusters. [PDF]

Data Brief
Alexyuk MS, Bogoyavlenskiy AP, Kerimov TT, Berezin VE, Alexyuk PG.   +4 more
europepmc   +1 more source

Parents' Perspectives on XR Distraction During Pediatric Needle Procedures. [PDF]

Paediatr Neonatal Pain
Hjelmgren H, Jungner JG, Bartholdson C, Kalholm K, Stålberg A.   +4 more
europepmc   +1 more source

Identification of Key Amino Acid Residues in the Adenylation Domains of Polymyxin Synthetase Responsible for l‑Threonine Adenylation in <i>Paenibacillus polymyxa</i> NBRC3020. [PDF]

ACS Omega
Ando W, Uemura Y, Nemoto M, Mano T, Lee M, Yuzawa S, Mizuno T.   +6 more
europepmc   +1 more source