Results 71 to 80 of about 14,800 (259)
Schematic representation of the hybrid NRPS-PKS cluster of pAMDE1. [PDF]
, 2013 Genes are colored according to the inferred function. NRPS and PKS domain architecture is shown inside boxes. NRPS and PKS gene numbers are indicated. C: Condensation domain, A: Adenylation domain, T: thiolation domain, Cy: modified condensation domain ...
Nikole E. Kimes (460765) +5 more
core +1 more source
Deconstruction of Human Age‐Related Cataract Capsules Defines Aging
Advanced Science, EarlyView.We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang +9 more
wiley +1 more source
Acta Pharmaceutica Sinica B, 2023 WS9326A is a peptide antibiotic containing a highly unusual N-methyl-E-2-3-dehydrotyrosine (NMet-Dht) residue that is incorporated during peptide assembly on a non-ribosomal peptide synthetase (NRPS).
Songya Zhang +18 more
doaj +1 more source
Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform
Advanced Science, EarlyView.Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao +10 more
wiley +1 more source
Phylogeny of bacterial NRPS sequences. [PDF]
, 2012 Relationships inferred by maximum likelihood analysis of bacterial NRPS adenylation domain fragments using the LG substitution model. Branch lengths indicate inferred divergence of amino acid sequences. Numbers adjacent to the nodes indicate aLRT support,
Daniel Man Yuen Sze (164166) +3 more
core +1 more source
Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota
Advanced Science, EarlyView.Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal +25 more
wiley +1 more source
NRPS Substrate Promiscuity Diversifies the Xenematides
Organic Letters, 2011 Xenematide, a cyclic depsipeptide antibiotic produced by Xenorhabdus nematophila, had a candidate nonribosomal peptide synthetase (NRPS) with atypical features. Differential metabolite analysis between a mutant and wildtype validated that this stand-alone NRPS was required for xenematide production, and further analysis led to a series of new ...
Crawford, Jason M. +4 more
openaire +2 more sources
Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy
Advanced Science, EarlyView.Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song +7 more
wiley +1 more source
Structures of known PKS-NRPS products [5–9]. [PDF]
, 2016 Structures of known PKS-NRPS products [5–9].
Thomas Ostenfeld Larsen (449793) +6 more
core +1 more source
Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases
Marine DrugsNonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents.
Mengli Zhang +5 more
doaj +1 more source