Results 71 to 80 of about 11,489 (200)

How Effective Are Ireland's Monitory Mechanisms in Improving Its Child Protection and Welfare Services?

Child &Family Social Work, EarlyView.
ABSTRACT Child protection and welfare systems are entrusted with significant power by governments and are therefore a significant focus of monitoring activities. Monitoring can help to build a better child protection system and to ensure child safety; track policy and legislative implementation and resource allocation; contribute to preventing systemic
Kenneth Burns, Eva Boyle, Susan Geary, Emma King   +3 more
wiley   +1 more source

PCR Optimization for Polyketide Synthase (PKS) and Non-Ribosomal Peptide Synthetase (NRPS) Gene Detection in Actinomycetes [PDF]

BIO Web of Conferences
Actinomycetes are known as a group of antimicrobial-producing bacteria. This is supported by the presence of potential genes in actinomycetes bacteria. These genes include Polyketide Synthase (PKS) and Non-Ribosomal Peptide Synthetase (NRPS).
Prayekti Endah, Hidayat Muhammad Taufiq, Putri Devita Rahma, Fajar Nur Syamsiatul   +3 more
doaj   +1 more source

The fertility effects of public pension: Evidence from the new rural pension scheme in China.

PLoS ONE, 2020
Public pension insurance has become a major form of social protection around the world. However, little is known about the association between public pension expansion and individuals' fertility in developing economies.
Zheng Shen, Xiaodong Zheng, Hualei Yang
doaj   +1 more source

Limbal cystotomy by fine needle aspiration of a translucent iris cyst in a horse

Equine Veterinary Education, EarlyView.
Summary A 4‐year‐old Cremello crossbred mare was referred to the Equine Veterinary Teaching Hospital of Utrecht University for a translucent iris cyst from the dorsal pupillary margin corpora nigra in the right eye. Although noninvasive diode laser treatment is the preferred method of pigmented cyst ablation, two attempts did not result in disruption ...
A. L. Hendrikx, S. Veraa, J. P. A. M. van Loon, H. Hermans, I. J. M. Slenter, E. M. S. Visser   +5 more
wiley   +1 more source

Caffeylpyruvate hydrolase from the bioluminescent fungus Neonothopanus gardneri is the key recycling enzyme in the fungal bioluminescence pathway

The FEBS Journal, EarlyView.
Caffeic acid is a central metabolite in the fungal bioluminescence pathway. We identified and characterized caffeylpyruvate hydrolase from Neonothopanus gardneri (ngarCPH) and demonstrate its ability to hydrolyze fungal oxyluciferin into caffeic and pyruvic acids, confirming a complete and self‐sustained fungal bioluminescence cycle.
Caio K. Zamuner, Douglas M. M. Soares, Bianca B. Nóbrega, Etelvino J. H. Bechara, Zinaida M. Kaskova, Alexander S. Mishin, Karen S. Sarkisyan, Ilia V. Yampolsky, Cassius V. Stevani   +8 more
wiley   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

High Cost and Low Trust: Insights From Qualitative Commercial Fishing Cost Data in the Northeast United States

Fisheries Management and Ecology, EarlyView.
ABSTRACT In fisheries management, socioeconomic data, specifically qualitative data analysis, is often underutilized. This study qualitatively analyzed a primary federal data collection effort in the Northeast United States, The Greater Atlantic Region Commercial Fishing Business Cost Survey.
Elizabeth D. Conley, Samantha Werner, Gregory Ardini, Matthew Cutler, Patricia M. Clay   +4 more
wiley   +1 more source

Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant‐Pathogen Interface

Plant Biotechnology Journal, EarlyView.
ABSTRACT The endoplasmic reticulum (ER) stress response, a conserved proteostasis network, has emerged as a central hub that reprograms plant immunity during pathogen attack. This review synthesises how plants harness ER‐stress signalling to mount multilayered defences and how pathogens have evolved counterstrategies to subvert these pathways.
Zhe Meng, Shuqin Zheng, Federica Brandizzi, Yiran Liu, Chunlei Li, Congcong Ai, Yujiao Wang, Jiadong Qi, Xiuguo Zhang   +8 more
wiley   +1 more source

Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A

Angewandte Chemie, Volume 138, Issue 26, 22 June 2026.
Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham, Edward S. Hems, Daniel C. L. Van, Justin E. Clarke, Sergey Nepogodiev, Julius S. P. Adamson, Christian Bassi, Michael E. Webb, Glyn R. Hemsworth, Orde Q. Munro, Barrie Wilkinson, Ryan F. Seipke   +11 more
wiley   +2 more sources

A rational multi-target combination strategy for synergistic improvement of non-ribosomal peptide production

Nature Communications
Non-ribosomal peptides (NRPs) are pharmaceutically important natural products that include numerous clinical drugs. However, the biosynthesis of these NRPs is intricately regulated and improving production through manipulation of multiple regulatory ...
Hao Yan, Zhenguo Xin, Ziwei Sang, Xingwang Li, Jia Xie, Jiale Wu, Shen Pang, Ying Wen, Weishan Wang   +8 more
doaj   +1 more source