Results 51 to 60 of about 30,531 (224)
Beilstein Journal of Organic Chemistry, 2013 Polyketides are biosynthesized through consecutive decarboxylative Claisen condensations between a carboxylic acid and differently substituted malonic acid thioesters, both tethered to the giant polyketide synthase enzymes.
Stephan Klopries +2 more
doaj +1 more source
Exploitation of Aspergillus terreus for the Production of Natural Statins
Journal of Fungi, 2016 The fungus Aspergillus (A.) terreus has dominated the biological production of the “blockbuster” drugs known as statins. The statins are a class of drugs that inhibit HMG-CoA reductase and lead to lower cholesterol production.
Mishal Subhan +2 more
doaj +1 more source
Microorganisms, 2020 (1) Background: Streptomyces sp. TP-A0598 derived from seawater produces lydicamycin and its congeners. We aimed to investigate its taxonomic status; (2) Methods: A polyphasic approach and whole genome analysis are employed; (3) Results: Strain TP-A0598 ...
Hisayuki Komaki +3 more
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Bioinspired iterative synthesis of polyketides [PDF]
Frontiers in Chemistry, 2015 Diverse array of biopolymers and second metabolites (particularly polyketide natural products) has been manufactured in nature through an enzymatic iterative assembly of simple building blocks. Inspired by this strategy, molecules with inherent modularity can be efficiently synthesized by repeated succession of similar reaction sequences.
Zheng, Kuan, Xie, Changmin, Hong, Ran
openaire +3 more sources
Adaptive Genomic Divergence Across Altitudes in Capsella bursa‐pastoris
Biological Diversity, EarlyView.Genomic divergence was observed between high‐altitude and low‐altitude populations of Capsella bursa‐pastoris in China, consistent with an important role of ecological factors. Candidate adaptive loci associated with enhanced energy metabolism, photoprotection, and growth plasticity under altitudinal stress were identified.
Lu Liu +4 more
wiley +1 more source
ChemFoodChem, EarlyView.Free phenolic hydroxyl groups in the chemical structure of the natural xanthone α‐mangostin (MGT) contribute positively to achieving the anticancer profile against murine colon cancer, murine triple negative breast cancer, and human osteosarcoma cancer. ABSTRACT The α‐mangostin (MGT) is a natural xanthone obtained from the pericarp of mangosteen fruit (
Otávio Augusto Chaves +7 more
wiley +1 more source
mSphere, 2019 The polyketide-derived secondary metabolite ascochitine is produced by species in the Didymellaceae family, including but not restricted to Ascochyta species pathogens of cool-season food legumes.
Wonyong Kim +5 more
doaj +1 more source
Polyketide stereotetrads in natural products [PDF]
Chemical Society Reviews, 2005 AbstractFor Abstract see ChemInform Abstract in Full Text.
Koskinen, Ari M.P., Karisalmi, Kaisa
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A Unified Approach for the Synthesis of Conformationally Locked and sp2‐sp3 Fused Hybrids
Chemistry – A European Journal, EarlyView.This study presents a systematic platform to build rigid sp2–sp3 hybrids via benzyne cycloadditions. Arene‑fused bicyclic oxa‐, aza‐, and carbocycles are converted into medicinally relevant amino acids and applied to Enalapril analogues synthesis. The hybrids combine aromatic interactions with 3D rigidity, tuning lipophilicity, pKa, and solubility ...
Ervis Saraci +8 more
wiley +1 more source
Química Nova, 2007 Eight compounds comprising four groups of polyketides, the xanthone fusarindin, the mixed peptide alkaloid-polyketide GKK1032, the anthraquinones crisophanol, citreoveridin and janthinone, and the azaphylones dihydrocitrinone, citrinin and citrinin H-1 ...
Renata Pastre +4 more
doaj +1 more source