Results 51 to 60 of about 39,295 (245)

Offloading Role of a Discrete Thioesterase in Type II Polyketide Biosynthesis

mBio, 2020
Type II polyketides are a group of secondary metabolites with various biological activities. In nature, biosynthesis of type II polyketides involves multiple enzymatic steps whereby key enzymes, including ketoacyl-synthase (KSα), chain length factor (KSβ)
Kangmin Hua, Xiangyang Liu, Yuchun Zhao, Yaojie Gao, Lifeng Pan, Haoran Zhang, Zixin Deng, Ming Jiang   +7 more
doaj   +1 more source

Manipulating polyketide stereochemistry by exchange of polyketide synthase modules

Chemical Communications, 2020
Exchange of polyketide synthase (PKS) modules by genetic engineering leads to efficient modification of polyketide stereochemistry.
Massicard, Jean-Malo, Soligot, Claire, Weissman, Kira J., Jacob, Christophe   +3 more
openaire   +4 more sources

Structure-activity relationship studies on the macrolide exotoxin mycolactone of Mycobacterium ulcerans [PDF]

, 2013
BACKGROUND: Mycolactones are a family of polyketide-derived macrolide exotoxins produced by Mycobacterium ulcerans, the causative agent of the chronic necrotizing skin disease Buruli ulcer.
Gerd Pluschke, Claudio Bomio, Philipp Gersbach, Scherr, Nicole, Jun Li, Claudio Bomio (396151), Nicole Scherr, Karl-Heinz Altmann, Jean-Pierre Dangy (42481), Gersbach, Philipp, Gersbach Philipp, Dangy Jean-Pierre, Jean-Pierre Dangy, Jun Li (6494), Pluschke Gerd, Li Jun, Bomio Claudio, Altmann, Karl-Heinz, Gerd Pluschke (7855), Philipp Gersbach (396150), Li, Jun, Scherr Nicole, Karl-Heinz Altmann (396152), Bomio, Claudio, Altmann Karl-Heinz, Pluschke, Gerd, Dangy, Jean-Pierre, Nicole Scherr (396149)   +27 more
core   +1 more source

Designing and implementing an assay for the detection of rare and divergent NRPS and PKS clones in European, Antarctic and Cuban soils [PDF]

, 2015
The ever increasing microbial resistome means there is an urgent need for new antibiotics. Metagenomics is an underexploited tool in the field of drug discovery. In this study we aimed to produce a new updated assay for the discovery of biosynthetic gene
David A Pearce, Gregory C A Amos, Gregory C. A. Amos (799040), Leo Calvo-Bado (507757), Berry, Andrew E., Chiara Borsetto (799041), Andrew E Berry, Laskaris, Paris, Calvo-Bado, Leo, Paris Laskaris, Carlos Vallin (5665333), Berry, Andrew, Calvo-Bado, Leo A., David A. Pearce (189743), Leo Calvo-Bado, Elizabeth M H Wellington, Chiara Borsetto, Elizabeth M. H. Wellington (325617), Borsetto, Chiara, Kevin K Newsham, Amos, Gregory, Carlos Vallin, Paris Laskaris (325613), Andrew E. Berry (799043), Martin Krsek, Wellington, Elizabeth M. H., Martin Krsek (799042), Pearce, David, Pearce, David A., Kevin K. Newsham (352778), Vallin, Carlos, Krsek, Martin, Wellington, Elizabeth, Newsham, Kevin, Wellington, E. M. H., Amos, Gregory C. A., Newsham, Kevin K.   +36 more
core   +1 more source

Retrosynthetic polyketide disconnections for unnatural aromatics [PDF]

, 2022
Polyketide synthases are extraordinarily complex enzymatic machineries that govern the assembly and cyclization of poly-β-carbonyl intermediates to an enormous diversity of natural products.
Sparr, Christof, Wu, Xingxing
core   +1 more source

Antibacterial and Antifungal Compounds from Marine Fungi

Marine Drugs, 2015
This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015.
Lijian Xu, Wei Meng, Cong Cao, Jian Wang, Wenjun Shan, Qinggui Wang   +5 more
doaj   +1 more source

Biosynthesis of Polyketides in Streptomyces [PDF]

Microorganisms, 2019
Polyketides are a large group of secondary metabolites that have notable variety in their structure and function. Polyketides exhibit a wide range of bioactivities such as antibacterial, antifungal, anticancer, antiviral, immune-suppressing, anti-cholesterol, and anti-inflammatory activity. Naturally, they are found in bacteria, fungi, plants, protists,
Risdian, Chandra, Mozef, Tjandrawati, Wink, Joachim   +2 more
openaire   +4 more sources

Cleaning up Polyketide Synthases [PDF]

, 2012
Complex biosynthetic enzymes such as polyketide synthases make mistakes. In this issue of Chemistry & Biology, Jensen et al. report that a discrete family of acyltransferases is responsible for error correction, hydrolyzing key biosynthetic intermediates
Schmidt, Eric W., Kwan, Jason C.
core   +1 more source

Chitosan‐Carbon Dot Composite Materials Form a Leaf Surface Barrier to Mitigate the Enrichment and Invasion of Nanoplastics: From Leaf Interface to Systemic Response

Advanced Science, EarlyView.
Foliar spraying of CS‐CDs can form a film on the leaves of Brassica rapa, effectively reducing the enrichment and absorption of PS in the leaves, while increasing the biomass and nutrient content of the plants. In addition, CS‐CDs can also enrich the interfoliar microbial community and activate the plant's own defense metabolic pathways.
Beibei Zhao, Mei Li, Mengjiao Fan, Chuanhuan Liu, Jie Jiang, Jia Song, Yingzhu Liu   +6 more
wiley   +1 more source

The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase [PDF]

Chemical Communications, 2017
Thiotetronate polyketide assembly by an unusual iterative synthase is reconstructedvia in vitroenzymology and chemical probes.
Marie E. Yurkovich, Robert Jenkins, Yuhui Sun, Manuela Tosin, Peter F. Leadlay   +4 more
openaire   +3 more sources