Results 51 to 60 of about 42,850 (196)

Cleaning up Polyketide Synthases [PDF]

, 2012
Complex biosynthetic enzymes such as polyketide synthases make mistakes. In this issue of Chemistry & Biology, Jensen et al. report that a discrete family of acyltransferases is responsible for error correction, hydrolyzing key biosynthetic intermediates
Schmidt, Eric W., Kwan, Jason C.
core   +1 more source

Discovery of Marine Natural Products as Promising Antibiotics against Pseudomonas aeruginosa

Marine Drugs, 2022
Pseudomonas aeruginosa, one of the most intractable Gram-negative bacteria, has become a public health threat due to its outer polysaccharide layer, efflux transporter system, and high level of biofilm formation, all of which contribute to multi-drug ...
Haoran Li, Mireguli Maimaitiming, Yue Zhou, Huaxuan Li, Pingyuan Wang, Yang Liu, Till F. Schäberle, Zhiqing Liu, Chang-Yun Wang   +8 more
doaj   +1 more source

The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase [PDF]

Chemical Communications, 2017
Thiotetronate polyketide assembly by an unusual iterative synthase is reconstructed via in vitro enzymology and chemical probes.
Marie E. Yurkovich, Robert Jenkins, Yuhui Sun, Manuela Tosin, Peter F. Leadlay   +4 more
openaire   +3 more sources

Secondary Metabolites from Marine-Derived Fungus Penicillium rubens BTBU20213035

Journal of Fungi
Two new polyketide derivatives, penirubenones A and B (1 and 2), and two naturally rare amino-bis-tetrahydrofuran derivatives, penirubenamides A and B (3 and 4), together with nine known compounds (5–13) were isolated from the marine-derived fungus ...
Xiuli Xu, Yifei Dong, Jinpeng Yang, Long Wang, Linlin Ma, Fuhang Song, Xiaoli Ma   +6 more
doaj   +1 more source

Exploitation of Aspergillus terreus for the Production of Natural Statins

Journal of Fungi, 2016
The fungus Aspergillus (A.) terreus has dominated the biological production of the “blockbuster” drugs known as statins. The statins are a class of drugs that inhibit HMG-CoA reductase and lead to lower cholesterol production.
Mishal Subhan, Rani Faryal, Ian Macreadie   +2 more
doaj   +1 more source

Streptomyces lydicamycinicus sp. nov. and Its Secondary Metabolite Biosynthetic Gene Clusters for Polyketide and Nonribosomal Peptide Compounds

Microorganisms, 2020
(1) Background: Streptomyces sp. TP-A0598 derived from seawater produces lydicamycin and its congeners. We aimed to investigate its taxonomic status; (2) Methods: A polyphasic approach and whole genome analysis are employed; (3) Results: Strain TP-A0598 ...
Hisayuki Komaki, Akira Hosoyama, Yasuhiro Igarashi, Tomohiko Tamura   +3 more
doaj   +1 more source

Quantification of N-acetylcysteamine activated methylmalonate incorporation into polyketide biosynthesis

Beilstein Journal of Organic Chemistry, 2013
Polyketides are biosynthesized through consecutive decarboxylative Claisen condensations between a carboxylic acid and differently substituted malonic acid thioesters, both tethered to the giant polyketide synthase enzymes.
Stephan Klopries, Uschi Sundermann, Frank Schulz   +2 more
doaj   +1 more source

The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110 [PDF]

, 2012
Schwientek P, Szczepanowski R, Rückert C, et al. The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110. BMC Genomics. 2012;13(1): 112.Background Actinoplanes sp.
Szczepanowski, Rafael, Kalinowski Jörn, Rückert Christian, Selber, Klaus, Udo F Wehmeier, Christian Ruckert, Jorn Kalinowski, Jens Stoye, Wehmeier Udo F, Pühler Alfred, Stoye, Jens ; https://orcid.org/, Kalinowski, Jörn, Selber Klaus, Stoye Jens, Klein, Andreas, Klaus Selber, Alfred Puhler, Pühler, Alfred ; https://orcid.org/, Schwientek, Patrick, Schwientek Patrick, Szczepanowski Rafael, Rückert, Christian ; https://orcid.org/, Rafael Szczepanowski, Patrick Schwientek, Andreas Klein, Wehmeier, Udo F., Klein Andreas   +26 more
core   +1 more source

Polyketide stereotetrads in natural products [PDF]

Chemical Society Reviews, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Koskinen, Ari M.P., Karisalmi, Kaisa
openaire   +3 more sources

Novel Mechanism for Priming Aromatic Polyketide Synthases [PDF]

, 2004
In this issue of Chemistry & Biology, a novel priming mechanism is proposed for aromatic polyketide biosynthesis, with an iterative type I polyketide synthase generating a starter unit primed for a type II polyketide synthase [6].
Salas, José A
core   +1 more source