Results 61 to 70 of about 42,850 (196)
mSphere, 2019 The polyketide-derived secondary metabolite ascochitine is produced by species in the Didymellaceae family, including but not restricted to Ascochyta species pathogens of cool-season food legumes.
Wonyong Kim +5 more
doaj +1 more source
Mining microbial genomes for new natural products and biosynthetic pathways [PDF]
, 2008 Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
G. L. Challis, Challis, Gregory L.
core +1 more source
Química Nova, 2007 Eight compounds comprising four groups of polyketides, the xanthone fusarindin, the mixed peptide alkaloid-polyketide GKK1032, the anthraquinones crisophanol, citreoveridin and janthinone, and the azaphylones dihydrocitrinone, citrinin and citrinin H-1 ...
Renata Pastre +4 more
doaj +1 more source
Recombinatorial biosynthesis of polyketides
Journal of Industrial Microbiology and Biotechnology, 2012 Abstract Modular polyketide synthases (PKSs) from Streptomyces and related genera of bacteria produce many important pharmaceuticals. A program called CompGen was developed to carry out in silico homologous recombination between gene clusters encoding PKSs and determine whether recombinants have cluster architectures compatible with the ...
Starcevic, A +7 more
openaire +5 more sources
An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase [PDF]
Journal of the American Chemical Society, 2018 Polyketides are a large class of bioactive natural products with a wide range of structures and functions. Polyketides are biosynthesized by large, multidomain enzyme complexes termed polyketide synthases (PKSs). One of the primary challenges when studying PKSs is the high reactivity of their poly-β-ketone substrates.
Bryan D. Ellis +10 more
openaire +5 more sources
Stress-Driven Discovery of Novel Cryptic Antibiotics from a Marine Fungus Penicillium sp. BB1122
Frontiers in Microbiology, 2017 Standard laboratory cultures have long been known to hinder activation of specific gene clusters which in turn hamper production of secondary metabolites with unique properties due to lack of innovation or the inability to trigger cryptic gene clusters ...
Bibi N. Auckloo +5 more
doaj +1 more source
Engineering Polyketide Synthases [PDF]
The Scientific World JOURNAL, 2002 Complex polyketides, exemplified by the molecules shown in Fig. 1, are produced mainly from a group of mycelia-forming bacteria belonging to the actinomycete family and have applications in medicine or agriculture. Worldwide sales of polyketides exceed $15 B annually.
openaire +3 more sources
Two New Polyketide Metabolites Isolated from Paraconiothyrium brasiliense
, 2017 Two new polyketide metabolites, named ethyl 8-hydroxy-9-oxo-9H-xanthene-1-carboxylate (1) and 1,8-dihydroxy-2-(1-hydroxyethyl)anthracene-9,10-dione (2), along with six known compounds, were isolated from the fungus Paraconiothyrium brasiliense.
Yang, T +6 more
core +1 more source
Molecules, 2011 Studies on the synthesis of macrosphelide B via an intramolecular nitrile oxide-olefin cycloaddition (INOC) is described. In particular, an asymmetric INOC approach using phase transfer catalysts seems to be a potentially efficient and versatile ...
Seung-Mann Paek, Young-Ger Suh
doaj +1 more source
New Polyketides from the Marine-Derived Fungus Letendraea Sp. 5XNZ4-2
Marine Drugs, 2019 Marine-derived fungi have been reported to have great potential to produce structurally unique metabolites. Our investigation on secondary metabolites from marine-derived fungi resulted in the isolation of seven new polyketides (phomopsiketones D−G
Yan Xu +8 more
doaj +1 more source