Results 81 to 90 of about 42,850 (196)

Structural studies on polyketide enzymes [PDF]

, 2008
Polyketides are a class of secondary metabolites that includes compounds with antibiotic and anticancer properties. In type I polyketide synthesis, the individual activities are arranged into large | polyproteins, while in type II polyketide synthesis ...
Dall'Aglio, Patrick
core  

Acyltransferases as Tools for Polyketide Synthase Engineering

, 2018
Polyketides belong to the most valuable natural products, including diverse bioactive compounds, such as antibiotics, anticancer drugs, antifungal agents, immunosuppressants and others.
Ewa Maria Musiol-Kroll, Ewa Maria Musiol-Kroll, Wolfgang Wohlleben   +2 more
core   +1 more source

Spotlight on Antimicrobial Metabolites from the Marine Bacteria Pseudoalteromonas: Chemodiversity and Ecological Significance

Marine Drugs, 2016
This review is dedicated to the antimicrobial metabolite-producing Pseudoalteromonas strains. The genus Pseudoalteromonas hosts 41 species, among which 16 are antimicrobial metabolite producers. To date, a total of 69 antimicrobial compounds belonging to
Clément Offret, Florie Desriac, Patrick Le Chevalier, Jérôme Mounier, Camille Jégou, Yannick Fleury   +5 more
doaj   +1 more source

Laccase and polyketide synthase genes.

, 2014
Laccase and polyketide synthase genes.
Ram Vinay Pandey (233450), Katja Sterflinger (490473), Barbara Blasi (641295), Ksenija Lopandic (641294), Albert Kriegner (34976)   +4 more
core   +1 more source

Structural characterization of iterative polyketide synthases

, 2020
Polyketide synthases are large multi-domain proteins found in bacterial and fungal species that synthesize structurally complex compounds called polyketides.
Tan, Jackie Yen
core   +1 more source

Synthetic Biology Tools for Polyketide Engineering [PDF]

, 2017
This thesis discusses the advancement of synthetic biology tools for polyketide engineering, specifically in the construction of a genetic device for the biosynthesis of a fluorinated monomer and the construction of polyketide pathways in yeast followed ...
Maryam Bint Muhammad (7951775)
core   +2 more sources

Three New Dipeptide and Two New Polyketide Derivatives from the Mangrove-Derived Fungus Talaromyces sp.: Antioxidant Activity of Two Isolated Substances

Marine Drugs
Five new metabolites, including three cyclic dipeptide derivatives (1–3) and two new polyketides (10–11), together with nine known ones (4–9 and 12–15), were isolated from the mangrove-sediments-derived fungus Talaromyces sp. SCSIO 41431.
Zhihao Zeng, Jian Cai, Yi Chen, Xinlong Li, Chunmei Chen, Yonghong Liu, Lalith Jayasinghe, Xuefeng Zhou   +7 more
doaj   +1 more source

Biosynthetic origin of butyrolactol A, an antifungal polyketide produced by a marine-derived Streptomyces

Beilstein Journal of Organic Chemistry, 2017
Butyrolactol A is an antifungal polyketide of Streptomyces bearing an uncommon tert-butyl starter unit and a polyol system in which eight hydroxy/acyloxy carbons are contiguously connected.
Enjuro Harunari, Hisayuki Komaki, Yasuhiro Igarashi   +2 more
doaj   +1 more source

General summary of type II polyketide biosynthesis.

, 2015
The key steps in type II polyketide biosynthesis—priming of the minimal polyketide synthase, extension of the polyketide chain by the ketosynthase α/β heterodimer to generate the poly-β-ketone intermediate, cyclization and aromatization of the poly-β ...
Benjamin J. Yackley (716539), Jacob A. Greenberg (716540), Snezna Rogelj (716541), Yasushi Ogasawara (716538), Charles E. Melançon III (716542)   +4 more
core   +1 more source

Marine fungi as a goldmine for novel antibiotics: a 2024 perspective

Frontiers in Marine Science
The microbial diversity in oceans is considerable, widely distributed in seawater, marine sediments, and marine organisms. Compared with terrestrial resources in traditional natural product research, the living environments of marine microorganisms are ...
Chengqian Pan, Syed Shams ul Hassan, Ishaq Muhammad, Huizi Jin   +3 more
doaj   +1 more source