Polyketide synthase complexes: their structure and function in antibiotic biosynthesis.
, 1991 This paper gives an overview of existing knowledge concerning the structure and deduced functions of polyketide synthases active in antibiotic-producing streptomycetes.
Robinson JA
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PLoS Biology, 2004 Polyketides, natural products from microorganisms, have been a main source of antibiotics. Understanding the 'programming' of the enzymes that produce these complex molecules has opened a new field of drug ...
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In vitro polyketide biocatalysis : triketide building-blocks and enzymology [PDF]
, 2013 textPolyketide products are useful compounds to research and industry but can be difficult to access due to their richness in stereogenic centers. Type I polyketide synthases offer unique engineering opportunities to access natural stereocontrol and ...
Harper, Andrew David
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Tolerance and specificity of polyketide synthases
, 1999 Polyketide synthases catalyze the assembly of complex natural products from simple precursors such as propionyl-CoA and methylmalonyl-CoA in a biosynthetic process that closely parallels fatty acid biosynthesis.
Khosla, Chaitan +3 more
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DISSECTING COMPLEX POLYKETIDE BIOSYNTHESIS
Computational and Structural Biotechnology Journal, 2012 Numerous bioactive natural products are synthesised by modular polyketide synthases. These compounds can be made in high yield by native multienzyme assembly lines. However, formation of analogues by genetically engineered systems is often considerably less efficient.
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Toward Complex Polyketide Biosynthesis in <i>Yarrowia lipolytica</i> via Metabolic Reprogramming. [PDF]
J Microbiol BiotechnolGhaempanah K, Son SH, Lee JY.
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Sustainable Biocatalytic Cascades: A Versatile Tool in the Synthesis of Natural Products With Therapeutic Potential. [PDF]
ChembiochemYadav RN +6 more
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Transcriptomic Analysis Reveals the Time-Dependent Mechanism of Antifungal Activity in <i>Bacillus velezensis</i> GHZJ-1. [PDF]
MicroorganismsChen W, Ni Y, Bai Y, Liu M, Xia M, Li B.
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Biosynthesis and Microbial Production of Carminic Acid: From Pathway Elucidation to Synthetic Biology. [PDF]
MicroorganismsLi H +5 more
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Diversifying Hybrid Polyketide Synthases through the Rapamycin Polyketide Synthase
Polyketide synthases are large protein complexes that make products called polyketides. Many of these products are medicines like the antibiotic erythromycin and the immunosuppressant agent rapamycin.
Jaegy, Hubert
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