Results 111 to 120 of about 39,295 (245)

Stepwise cyclopropanation on the polycyclopropanated polyketide formation in jawsamycin biosynthesis [PDF]

, 2017
Jawsamycin is a polyketide-nucleoside hybrid with a unique poly-cyclopropane moiety on a single polyketide chain. The unexpected isolation of cyclopropane deficient jawsamycin analogs allowed us to propose a stepwise cyclopropanation mechanism for the ...
Suzuki, Hideaki, Oikawa, Hideaki, Hiratsuka, Tomoshige, Minami, Atsushi   +3 more
core   +1 more source

Comparison of Three Sympatric Desert Lizards: Digestive Tract Structure, Digestive Enzyme Activities, Gut Microbiota, and Metabolites

Integrative Zoology, EarlyView.
We performed 16S rDNA sequencing and metabolite profiling for three sympatric lizard species—Teratoscincus roborowskii, Phrynocephalus axillaris, and Eremias roborowskii—and compared their goblet cell and enzyme activities in the digestive tract. Our study suggests that the dietary niche may promote divergence or convergence of microbiota across host ...
Yi Yang, Ziyi Wang, Ruichen Wu
wiley   +1 more source

Structural studies on polyketide enzymes [PDF]

, 2008
Polyketides are a class of secondary metabolites that includes compounds with antibiotic and anticancer properties. In type I polyketide synthesis, the individual activities are arranged into large | polyproteins, while in type II polyketide synthesis ...
Dall'Aglio, Patrick
core  

Studies in Polyketide Total Synthesis [PDF]

, 2014
This dissertation will describe the development of a practical and scalable crotylation reaction with application toward the total syntheses of two polyketide-derived natural products: Zincophorin and ...
Ho, Stephen
core   +2 more sources

Caffeylpyruvate hydrolase from the bioluminescent fungus Neonothopanus gardneri is the key recycling enzyme in the fungal bioluminescence pathway

The FEBS Journal, EarlyView.
Caffeic acid is a central metabolite in the fungal bioluminescence pathway. We identified and characterized caffeylpyruvate hydrolase from Neonothopanus gardneri (ngarCPH) and demonstrate its ability to hydrolyze fungal oxyluciferin into caffeic and pyruvic acids, confirming a complete and self‐sustained fungal bioluminescence cycle.
Caio K. Zamuner, Douglas M. M. Soares, Bianca B. Nóbrega, Etelvino J. H. Bechara, Zinaida M. Kaskova, Alexander S. Mishin, Karen S. Sarkisyan, Ilia V. Yampolsky, Cassius V. Stevani   +8 more
wiley   +1 more source

‐AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide [PDF]

, 2016
Phormidolide is a polyketide produced by a cultured filamentous marine cyanobacterium and incorporates a 16-membered macrolactone. Its complex structure is recognizably derived from a polyketide synthase pathway, but possesses unique and intriguing ...
Alexandra Vulpanovici, Bertin, Matthew J, Gerwick, William H, Emily A. Monroe, Gerwick, Lena, Matthew J. Bertin, William H. Gerwick, Korobeynikov, Anton, Lena Gerwick, Vulpanovici, Alexandra, Anton Korobeynikov, Sherman, David H, Monroe, Emily A, David H. Sherman   +13 more
core   +1 more source

The unusual mode of action of the polyketide glycoside antibiotic cervimycin C

mSphere
Cervimycins A–D are bis-glycosylated polyketide antibiotics produced by Streptomyces tendae HKI 0179 with bactericidal activity against Gram-positive bacteria.
Alina Hoffmann, Ursula Steffens, Boris Maček, Mirita Franz-Wachtel, Kay Nieselt, Theresa Anisja Harbig, Kirstin Scherlach, Christian Hertweck, Hans-Georg Sahl, Gabriele Bierbaum   +9 more
doaj   +1 more source

Orchid genome evolution and trait innovation

Journal of Integrative Plant Biology, EarlyView.
Orchids became one of the world's most diverse plant groups through genome‐driven innovations, unique relationships with fungi and pollinators, and remarkable adaptability. This review explains the origins of orchids and the evolution of their distinctive life forms, flowers, and ecological strategies and highlights promising directions for future ...
Meng‐Yao Zeng, Cheng‐Yuan Zhou, Linying Wang, Jie Gao, Weilun Yin, Dong‐Hui Peng, Siren Lan, Feng‐Xi Yang, Zhong‐Jian Liu   +8 more
wiley   +1 more source

Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived Streptomyces sp. HDN150000

Marine Drugs
Three new structures named naphpyrone I–K (1–3) that contain a 6/6/6/6 oxaphenalene pyranone skeleton were isolated and purified from a marine-derived Streptomyces sp. HDN155000.
Xiaoting Zhang, Falei Zhang, Wenxue Wang, Xingtao Ren, Tianjiao Zhu, Qian Che, Dehai Li, Guojian Zhang   +7 more
doaj   +1 more source

Impact of the invasive diatom species Cymbella janischii on riverine microbial biofilm communities and a potential role of bacterially produced zeatin

Journal of Phycology, EarlyView.
Abstract The diatom Cymbella janischii is an invasive species in Japan, causing nuisance blooms by forming thick mats in rivers. To date, there are no documented studies on the microbiome associations in C. janischii mats or the processes that drive bloom formation.
Eldrin D. L. R. Arguelles, Kana Mugikura, Shinya Sato   +2 more
wiley   +1 more source