Results 91 to 100 of about 23,262 (184)

Computational structural enzymology methodologies for the study and engineering of fatty acid synthases, polyketide synthases and nonribosomal peptide synthetases [PDF]

, 2019
Various computational methodologies can be applied to enzymological studies on enzymes in the fatty acid, polyketide, and non-ribosomal peptide biosynthetic pathways. These multi-domain complexes are called fatty acid synthases, polyketide synthases, and
Schaub, Andrew J, Tsai, Shiou-Chuan, Andrew J. Schaub, Truong, Hau V, Moreno, Gabriel O, Shiou-Chuan Tsai, Luo, Ray, Hau V. Truong, Ray Luo, Gabriel O. Moreno, Zhao, Shiji, Shiji Zhao   +11 more
core   +1 more source

Reprogramming of the Aurantinin Polyketide Assembly Line to Synthesize Auritriacids by Excising an Atypical Enoyl‐CoA Hydratase Domain

Advanced Science
Modular polyketide synthases (PKSs) are capable of synthesizing diverse natural products with fascinating bioactivities. Canonical enoyl‐CoA hydratases (ECHs) are components of the β‐branching cassette that modifies the polyketide chain by adding a β ...
Dacheng Wang, Huijin Mao, Zelian Zhao, Lilu Liu, Yihua Chen, Pengwei Li   +5 more
doaj   +1 more source

Caffeylpyruvate hydrolase from the bioluminescent fungus Neonothopanus gardneri is the key recycling enzyme in the fungal bioluminescence pathway

The FEBS Journal, EarlyView.
Caffeic acid is a central metabolite in the fungal bioluminescence pathway. We identified and characterized caffeylpyruvate hydrolase from Neonothopanus gardneri (ngarCPH) and demonstrate its ability to hydrolyze fungal oxyluciferin into caffeic and pyruvic acids, confirming a complete and self‐sustained fungal bioluminescence cycle.
Caio K. Zamuner, Douglas M. M. Soares, Bianca B. Nóbrega, Etelvino J. H. Bechara, Zinaida M. Kaskova, Alexander S. Mishin, Karen S. Sarkisyan, Ilia V. Yampolsky, Cassius V. Stevani   +8 more
wiley   +1 more source

Overlooked components of lipid metabolism: Odd‐chain polyunsaturated fatty acids in photosynthetic microorganisms

Journal of Phycology, EarlyView.
Abstract This mini‐review examines odd‐carbon polyunsaturated fatty acids (odd‐PUFAs), a rare but biologically significant group of fatty acids in photosynthetic microorganisms. Odd‐PUFAs are straight‐chain fatty acids containing an odd number of carbon atoms and two or more methylene‐interrupted double bonds. They typically account for less than 1% of
Linda Nedbalová, Milada Vítová, Tomáš Řezanka   +2 more
wiley   +1 more source

Polyketide synthases as a platform for chemical product design

, 2018
To reduce the effects of greenhouse gas emissions on climate change, scientific efforts have sought to develop biofuels and bio-based commodity chemicals as petrochemical replacements primarily for their environmental benefits.
Keasling, Jay D., Zargar, Amin, Barajas, Jesus F., Lal, Ravi   +3 more
core   +1 more source

Evidence for an iterative module in chain elongation on the azalomycin polyketide synthase

Beilstein Journal of Organic Chemistry, 2016
The assembly-line synthases that produce bacterial polyketide natural products follow a modular paradigm in which each round of chain extension is catalysed by a different set or module of enzymes.
Hui Hong, Yuhui Sun, Yongjun Zhou, Emily Stephens, Markiyan Samborskyy, Peter F. Leadlay   +5 more
doaj   +1 more source

Draft genome sequence of a human-associated isolate of Haloferax alexandrinus strain Arc-hr, an extremely halophilic archaea

New Microbes and New Infections, 2017
We report the draft genome sequence of Haloferax alexandrinus strain Arc-hr (CSUR P798), isolated from the human gut of a 10-year-old Amazonian individual. Its 3 893 626 bp genome exhibits a 66.00% GC content.
S. Khelaifia, A. Caputo, F. Djossou, D. Raoult   +3 more
doaj   +1 more source

Deciphering Role of Endophytes in Plant Defences and Biotic Stress Resilience Across Families

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant families generate distinct repertoires of specialised metabolites that govern their biotic interactions. Endophytes strengthen host plant defence mechanisms and tolerance to biotic challenges by upregulating metabolite biosynthesis, modifying precursor compounds into more potent forms, or by directly synthesising analogous defence ...
S. Aneeqa Noor, Kavita Verma, Nishu, Barkat Hussain, Vartika Mathur   +4 more
wiley   +1 more source

Correction: Uncovering the structures of modular polyketide synthases

, 2017
Correction for ‘Uncovering the structures of modular polyketide synthases’ by Kira J. Weissman, Nat. Prod. Rep., 2015, 32, 436–453.
Kira J. Weissman
core   +1 more source

Detection of Mycolactone A/B in Mycobacterium ulcerans-Infected Human Tissue. [PDF]

, 2010
BACKGROUND: Mycobacterium ulcerans disease (Buruli ulcer) is a neglected tropical disease common amongst children in rural West Africa. Animal experiments have shown that tissue destruction is caused by a toxin called mycolactone.
Engy A. Mahrous, Richard O. Phillips, Lee Richard E., Engy A Mahrous, Pamela L. Small, Lee, RE, Mark H. Wansbrough-Jones, Phillips Richard O., Sarfo, FS, Small, PL, Edward Tarelli, Pamela L Small, Mahrous, EA, Mark H Wansbrough-Jones, Wansbrough-Jones, MH, Kingsley B Asiedu, Tarelli, E, Rangers Brian, Rangers, B, Kingsley B. Asiedu, Mahrous Engy A., Tarelli Edward, Wansbrough-Jones Mark H., Richard O Phillips, Small Pamela L., Brian Rangers, Asiedu Kingsley B., Phillips, RO, Asiedu, KB, Sarfo Fred Stephen, Fred Stephen Sarfo, Richard E. Lee, Richard E Lee   +32 more
core   +1 more source