Results 71 to 80 of about 23,262 (184)

ExMODE: A comprehensive resource for extremophile genomic and functional exploration

iMetaOmics, EarlyView.
ExMODE (https://db.genomics.cn/exmode/) integrates 3518 samples to build a unified extremophile resource, which hosts 1.35 billion habitat‐specific non‐redundant genes, 5.25 million representative protein structures, 67,026 metagenome‐assembled genomes (MAGs), and 164,132 biosynthetic gene clusters (BGCs). By combining sequence‐, structure‐, and genome‐
Denghui Li, Kailong Ma, Xiaoqiang Li, Jieni Wang, Zhen Cui, Yulu Zhang, Weiwen Wang, Jiawei Tong, Yang Guo, Zongan Wang, Peiyun Zeng, Jieyu Wang, Xiaokai Xu, Nannan Zhang, Yingying Zhang, Jing Chen, Qingjiang Hu, Wenzhen Yang, Zhiyong Li, Tao Yang, Wensi Du, Zhicheng Xu, Zhen Yue, Jian Wang, Guangyi Fan, Weijia Zhang, Xun Xu, Liujie Huo, Xiaofeng Wei, Liang Meng, Shanshan Liu   +30 more
wiley   +1 more source

Biosynthesis of polyketide synthase extender units [PDF]

Nat. Prod. Rep., 2009
This review covers the biosynthesis of extender units that are utilized for the assembly of polyketides by polyketide synthases. The metabolic origins of each of the currently known polyketide synthase extender units are covered.
Yolande A, Chan, Angela M, Podevels, Brian M, Kevany, Michael G, Thomas   +3 more
openaire   +2 more sources

Engineering fatty acid synthases for directed polyketide production. [PDF]

, 2017
In this study, we engineered fatty acid synthases (FAS) for the biosynthesis of short-chain fatty acids and polyketides, guided by a combined in vitro and in silico approach.
Cortina, N., Grubmüller, H., Sascha Serdjukow, Grubmüller, Helmut, Grininger, M., Melanie Janßen, Gajewski, J., Helmut Grubmüller, Serdjukow, S., Jan Gajewski, Martin Grininger, Cortina, Niña, Floris Buelens, Niña Cortina, Janßen, Melanie, Buelens, F., Janßen, M., Gajewski, Jan, Buelens, Floris, Grininger, Martin, Grubmueler, H., Serdjukow, Sascha   +21 more
core   +1 more source

Structural and Functional Studies of Polyketide Synthases [PDF]

, 2018
Polyketides, natural products produced by multi-domain polyketide synthases (PKSs), have proven to be excellent starting points for drug discovery. Rational engineering of PKSs holds much promise for the generation of novel polyketide pharmaceuticals ...
Drulyte, Ieva
core   +5 more sources

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Evolutionary Implications of Bacterial Polyketide Synthases [PDF]

Molecular Biology and Evolution, 2005
Polyketide synthases (PKS) perform a stepwise biosynthesis of diverse carbon skeletons from simple activated carboxylic acid units. The products of the complex pathways possess a wide range of pharmaceutical properties, including antibiotic, antitumor, antifungal, and immunosuppressive activities. We have performed a comprehensive phylogenetic analysis
Holger, Jenke-Kodama, Axel, Sandmann, Rolf, Müller, Elke, Dittmann   +3 more
openaire   +2 more sources

FUNGAL TYPE I POLYKETIDE SYNTHASES

, 2009
Fungi produce a wide variety of biologically active compounds, a large proportion of which are produced by the polyketide biosynthetic pathway. Fungal polyketides comprise a very large and structurally very diverse group, and many display important ...
Simpson, Thomas J., Thomas J. Simpson, Cox, Russell J., Russell J. Cox   +3 more
core   +1 more source

The malonyl/acetyl-transferase from murine fatty acid synthase is a promiscuous engineering tool for editing polyketide scaffolds

Communications Chemistry
Modular polyketide synthases (PKSs) play a vital role in the biosynthesis of complex natural products with pharmaceutically relevant properties. Their modular architecture makes them an attractive target for engineering to produce platform chemicals and ...
Lynn Buyachuihan, Simon Reiners, Yue Zhao, Martin Grininger   +3 more
doaj   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

The Structure of Docking Domains in Modular Polyketide Synthases [PDF]

, 2003
Polyketides from actinomycete bacteria provide the basis for many valuable medicines, so engineering genes for their biosynthesis to produce variant molecules holds promise for drug discovery. The modular polyketide synthases are particularly amenable to
Nietlispach, Daniel, Broadhurst, R.William, Weissman, Kira J, Leadlay, Peter F, Wheatcroft, Michael P   +4 more
core   +1 more source