Results 61 to 70 of about 23,262 (184)
Genomic mining and diversity of assembly line polyketide synthases
Open Biology, 2023 Assembly line polyketide synthases (PKSs) are a large family of multifunctional enzymes responsible for synthesizing many medicinally relevant natural products with remarkable structural variety and biological activity.
Shreya Kishore, Chaitan Khosla
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Frontiers in Chemistry, 2018 The structure diversity of type II polyketide synthases-derived bacterial aromatic polyketides is often enhanced by enzyme controlled or spontaneous cyclizations.
Chunshuai Huang +7 more
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Chemistry of a Unique Polyketide-like Synthase [PDF]
Journal of the American Chemical Society, 2018 Like many complex natural products, the intricate architecture of saxitoxin (STX) has hindered full exploration of this scaffold's utility as a tool for studying voltage-gated sodium ion channels and as a pharmaceutical agent. Established chemical strategies can provide access to the natural product; however, a chemoenzymatic route to saxitoxin that ...
Stephanie W. Chun +3 more
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Assessing and harnessing updated polyketide synthase modules through combinatorial engineering
Nature CommunicationsThe modular nature of polyketide assembly lines and the significance of their products make them prime targets for combinatorial engineering. The recently updated module boundary has been successful for engineering short synthases, yet larger synthases ...
Katherine A. Ray +8 more
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Structural characterization of iterative polyketide synthases
, 2020 Polyketide synthases are large multi-domain proteins found in bacterial and fungal species that synthesize structurally complex compounds called polyketides.
Tan, Jackie Yen
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Polyketides, Toxins and Pigments in Penicillium marneffei
Toxins, 2015 Penicillium marneffei (synonym: Talaromyces marneffei) is the most important pathogenic thermally dimorphic fungus in China and Southeastern Asia. The HIV/AIDS pandemic, particularly in China and other Southeast Asian countries, has led to the emergence ...
Emily W. T. Tam +3 more
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Fungal non-reducing polyketide synthases - Plot 2
, 2016 This is a strip plot of fungal non-reducing polyketide synthases PT domain hits across several different environmental ...
Ara Kooser (100048)
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Fungal non-reducing polyketide synthases - Plot 1
, 2016 This is a strip plot of fungal non-reducing polyketide synthases PT domain hits across several different environmental ...
Ara Kooser (100048)
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Bioinformatics analysis and engineering of polyketide synthases
, 2022 Type I modular polyketide synthases (PKSs) catalyze the natural synthesis of some of the most clinically effective polyketides, including the anti-cancer epothilone and antibiotic erythromycin.
Hirsch, Melissa
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Basidiomycete non-reducing polyketide synthases function independently of SAT domains
Fungal Biology and Biotechnology, 2023 Background Non-reducing polyketide synthases (NR-PKSs) account for a major share of natural product diversity produced by both Asco- and Basidiomycota. The present evolutionary diversification into eleven clades further underscores the relevance of these
Nikolai A. Löhr +5 more
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