Results 51 to 60 of about 23,262 (184)
Nature Communications, 2021 Engineering efforts have focused on acyltransferase (AT) domains of modular polyketide synthases (PKSs) to site-selectively modify the resulting polyketides, but critical AT residues involved in substrate selection have not been fully elucidated.
Edward Kalkreuter +6 more
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Mining microbial genomes for new natural products and biosynthetic pathways [PDF]
, 2008 Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
G. L. Challis, Challis, Gregory L.
core +1 more source
Evolutionary Histories of Type III Polyketide Synthases in Fungi
Frontiers in Microbiology, 2020 Type III polyketide synthases (PKSs) produce secondary metabolites with diverse biological activities, including antimicrobials. While they have been extensively studied in plants and bacteria, only a handful of type III PKSs from fungi has been ...
Jorge Carlos Navarro-Muñoz +1 more
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Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota
Advanced Science, EarlyView.Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal +25 more
wiley +1 more source
Polyketide Synthase Modules Redefined [PDF]
Angewandte Chemie International Edition, 2017 Modular redefinition: A long-standing paradigm in modular polyketide synthase enzymology, namely the definition of a module, has been challenged by Abe and co-workers in their recent study. With this new understanding has emerged renewed hope for engineering these assembly lines to produce new materials and medicines.
openaire +2 more sources
Short-chain ketone production by engineered polyketide synthases in Streptomyces albus
Nature Communications, 2018 Mutating natural enzymes is effective in broadening the substrate or product range, but generally leads to reduced titers. Here the authors engineer hybrid polyketide synthases for efficient production of short-chain ketones from plant biomass ...
Satoshi Yuzawa +15 more
doaj +1 more source
Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges
Advanced Science, EarlyView.Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen +6 more
wiley +1 more source
The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase [PDF]
Chemical Communications, 2017 Thiotetronate polyketide assembly by an unusual iterative synthase is reconstructed via in vitro enzymology and chemical probes.
Marie E. Yurkovich +4 more
openaire +3 more sources
Optimizing the production of and engineering polyketide synthases [PDF]
, 2019 Polyketide synthases are enormous modular enzymes that synthesize large acyl chains known as polyketides. Common polyketides include pharmaceuticals such as antibiotics, immunosuppressants, and antifungals1.
Shah, Prachi
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ASMPKS: an analysis system for modular polyketide synthases
BMC Bioinformatics, 2007 Background Polyketides are secondary metabolites of microorganisms with diverse biological activities, including pharmacological functions such as antibiotic, antitumor and agrochemical properties. Polyketides are synthesized by serialized reactions of a
Kong Eun-Bae, Tae Hongseok, Park Kiejung
doaj +1 more source