Results 31 to 40 of about 23,262 (184)

Platensimycin Activity against Mycobacterial β-Ketoacyl-ACP Synthases [PDF]

, 2009
Background - There is an urgent need for the discovery and development of new drugs against Mycobacterium tuberculosis, the causative agent of tuberculosis, especially due to the recent emergence of multi-drug and extensively-drug resistant strains ...
Gurdyal S Besra, Alistair K. Brown, Bhatt, Apoorva; id_orcid, Apoorva Bhatt, Bhatt Apoorva, Besra, Gurdyal; id_orcid, Klaus Fütterer, Besra, Gurdyal, Futterer, Klaus, Taylor, Rebecca, Rebecca C Taylor, Fütterer Klaus, Besra Gurdyal S., Bhatt, Apoorva, Alistair K Brown, Taylor Rebecca C., Rebecca C. Taylor, Gurdyal S. Besra, Brown Alistair K., Brown, Alistair   +19 more
core   +1 more source

Molecular basis for extender unit specificity of mycobacterial polyketide synthases

, 2020
International audienceMycobacterium tuberculosis is the causative agent of the tuberculosis disease, which claims more human lives each year than any other bacterial pathogen. M.
Gavalda, Sabine, Grabowska, Anna,, Faille, Alexandre, Guilhot, Christophe, Nahoum, Virginie, Pedelacq, Jean-Denis, Chalut, Christian, Mourey, Lionel, Brison, Yoann, Maveyraud, Laurent, Bon, Cécile   +10 more
core   +2 more sources

Identification of a putative polyketide synthase gene involved in usnic acid biosynthesis in the lichen Nephromopsis pallescens.

PLoS ONE, 2018
Usnic acid is a unique polyketide produced by lichens. To characterize usnic acid biosynthesis, the transcriptome of the usnic-acid-producing lichen-forming fungus Nephromopsis pallescens was sequenced using Illumina NextSeq technology.
Yi Wang, Changan Geng, Xiaolong Yuan, Mei Hua, Fenghua Tian, Changtian Li   +5 more
doaj   +1 more source

Expansion and Conservation of Biosynthetic Gene Clusters in Pathogenic Pyrenophora spp.

Toxins, 2020
Pyrenophora is a fungal genus responsible for a number of major cereal diseases. Although fungi produce many specialised or secondary metabolites for defence and interacting with the surrounding environment, the repertoire of specialised metabolites (SM)
Paula M. Moolhuijzen, Mariano Jordi Muria-Gonzalez, Robert Syme, Catherine Rawlinson, Pao Theen See, Caroline S. Moffat, Simon R. Ellwood   +6 more
doaj   +1 more source

Suzuki–Miyaura Reaction in the Presence of N-Acetylcysteamine Thioesters Enables Rapid Synthesis of Biomimetic Polyketide Thioester Surrogates for Biosynthetic Studies

Chemistry, 2023
Biomimetic N-acetylcysteamine thioesters are essential for the study of polyketide synthases, non-ribosomal peptide synthetases and fatty acid synthases.
Sebastian Derra, Luca Schlotte, Frank Hahn   +2 more
doaj   +1 more source

A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones [PDF]

Angewandte Chemie International Edition, 2018
AbstractEnzymatic core components from trans‐acyltransferase polyketide synthases (trans‐AT PKSs) catalyze exceptionally diverse biosynthetic transformations to generate structurally complex bioactive compounds. Here we focus on a group of oxygenases identified in various trans‐AT PKS pathways, including those for pederin, oocydins, and toblerols ...
Roy A. Meoded, Reiko Ueoka, Eric J. N. Helfrich, Katja Jensen, Nancy Magnus, Birgit Piechulla, Jörn Piel   +6 more
openaire   +5 more sources

Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont

Angewandte Chemie, EarlyView.
Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley, Michael Rust, Moritz Wagner, Ida R. Hipfinger, Paul J. N. Böhm, Cora L. Dieterich, Christopher M. Field, Michael J. Page, Jeremy G. Owen, Robert A. Keyzers, Shinichi Sunagawa, Jörn Piel   +11 more
wiley   +2 more sources

New Kendomycin Derivative Isolated from Streptomyces sp. Cl 58-27

Molecules, 2021
In the course of screening new streptomycete strains, the strain Streptomyces sp. Cl 58-27 caught our attention due to its interesting secondary metabolite production profile.
Constanze Paulus, Oleksandr Gromyko, Andriy Luzhetskyy   +2 more
doaj   +1 more source

Intermolecular Carbon–Carbon Naphthalene Coupling Involves a Radical Mechanism Driven by Cytochrome P450 in Alternaria alternata

Angewandte Chemie, EarlyView.
1,8‐DHN is an important intermediate to form complex aromatic ring systems. Phenol‐coupling reactions are important for the dimerization of two molecules. Here, we show that a fungal cytochrome P450 enzyme catalyzes specific C─C bonds. ABSTRACT Dihydroxynaphthalene (DHN) derivatives are precursors of biologically important molecules, including melanin ...
Jia Gao, Leyao Chen, Karin Steffen, Henrik Schweder, Birgit Schreckenberger, Shu‐Ming Li, Ben Auxier, Antonis Rokas, Reinhard Fischer   +8 more
wiley   +2 more sources

Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl‐Substituted, α‐Oxidized γ‐Amino Acids

Angewandte Chemie, EarlyView.
Genome mining of atypical condensation (C) domains leads to the discovery of myxoglucamides, glycolipopeptides featuring an unprecedented vinyl‐substituted, α‐oxidized γ‐amino acid. Biosynthetic studies reveal a discrete C‐domain‐like O‐acyltransferase, a β‐hydroxylation‐dependent chain‐extension checkpoint, and an unusual pathway for γ‐amino acid ...
Tingting Wang, Alexander Popoff, Maja Hunter, Guangzhi Dai, Ronald Garcia, Huixin Xu, Haowen Zhao, Asfandyar Sikandar, Liujie Huo, Rolf Müller, Chengzhang Fu   +10 more
wiley   +2 more sources