Results 11 to 20 of about 23,262 (184)
Cleaning up Polyketide Synthases [PDF]
Chemistry & Biology, 2012 Complex biosynthetic enzymes such as polyketide synthases make mistakes. In this issue of Chemistry & Biology, Jensen et al. report that a discrete family of acyltransferases is responsible for error correction, hydrolyzing key biosynthetic intermediates from a multi-enzyme complex. This activity might find use in understanding polyketide biosynthesis,
Kwan, Jason C., Schmidt, Eric W.
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Tolerance and Specificity of Polyketide Synthases
Annual Review of Biochemistry, 1999 ▪ Abstract Polyketide synthases catalyze the assembly of complex natural products from simple precursors such as propionyl-CoA and methylmalonyl-CoA in a biosynthetic process that closely parallels fatty acid biosynthesis. Like fatty acids, polyketides are assembled by successive decarboxylative condensations of simple precursors.
C, Khosla +3 more
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Biosynthesis of polyketides by trans-AT polyketide synthases
Natural Product Reports, 2016 This review discusses the biosynthesis of natural products that are generated by trans -AT polyketide synthases, a family of catalytically versatile enzymes that represents one of the major group of proteins involved in the production of bioactive polyketides.
Helfrich Eric J N, Piel Jörn
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Diversifying Hybrid Polyketide Synthases through the Rapamycin Polyketide Synthase
Polyketide synthases are large protein complexes that make products called polyketides. Many of these products are medicines like the antibiotic erythromycin and the immunosuppressant agent rapamycin. These synthases are composed of sequential subunits called modules.
Jaegy, Hubert
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Engineering Polyketide Synthases [PDF]
The Scientific World Journal, 2002 Complex polyketides, exemplified by the molecules shown in Fig. 1, are produced mainly from a group of mycelia-forming bacteria belonging to the actinomycete family and have applications in medicine or agriculture. Worldwide sales of polyketides exceed $15 B annually.
Leonard Katz
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Acyltransferases as Tools for Polyketide Synthase Engineering [PDF]
Antibiotics, 2018 Polyketides belong to the most valuable natural products, including diverse bioactive compounds, such as antibiotics, anticancer drugs, antifungal agents, immunosuppressants and others.
Ewa Maria Musiol-Kroll +1 more
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Structure of a modular polyketide synthase [PDF]
Nature, 2014 Polyketide natural products constitute a broad class of compounds with diverse structural features and biological activities. Their biosynthetic machinery, represented by type I polyketide synthases (PKSs), has an architecture in which successive modules catalyse two-carbon linear extensions and keto-group processing reactions on intermediates ...
Dutta, Somnath +10 more
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Synthetic biology of polyketide synthases [PDF]
Journal of Industrial Microbiology and Biotechnology, 2018 Abstract Complex reduced polyketides represent the largest class of natural products that have applications in medicine, agriculture, and animal health. This structurally diverse class of compounds shares a common methodology of biosynthesis employing modular enzyme systems called polyketide synthases (PKSs).
Yuzawa, Satoshi +3 more
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Aspergillus westerdijkiae polyketide synthase gene “aoks1” is involved in the biosynthesis of ochratoxin A [PDF]
, 2009 OchratoxinA (OTA) is a potential nephrotoxic, teratogenic, immunogenic, hepatotoxic and carcinogenic mycotoxin, produced by Aspergillus westerdijkiae NRRL 3174.
Atoui, Ali +4 more
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Cloning and characterization of novel methylsalicylic acid synthase gene involved in the biosynthesis of isoasperlactone and asperlactone in Aspergillus westerdijkiae [PDF]
, 2009 Aspergillus westerdijkiae is the main producer of several biologically active polyketide metabolites including isoasperlactone and asperlactone. A 5298 bp polyketide synthase gene ‘‘aomsas” has been cloned in Aspergillus westerdijkiae by using gene ...
Atoui, Ali +10 more
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