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The Stereochemistry of Complex Polyketide Biosynthesis by Modular Polyketide Synthases
Molecules, 2011 Polyketides are a diverse class of medically important natural products whose biosynthesis is catalysed by polyketide synthases (PKSs), in a fashion highly analogous to fatty acid biosynthesis.
David H. Kwan, Frank Schulz
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Engineering Polyketide Synthases [PDF]
The Scientific World Journal, 2002 Complex polyketides, exemplified by the molecules shown in Fig. 1, are produced mainly from a group of mycelia-forming bacteria belonging to the actinomycete family and have applications in medicine or agriculture. Worldwide sales of polyketides exceed $15 B annually.
Leonard Katz
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Acyltransferases as Tools for Polyketide Synthase Engineering [PDF]
Antibiotics, 2018 Polyketides belong to the most valuable natural products, including diverse bioactive compounds, such as antibiotics, anticancer drugs, antifungal agents, immunosuppressants and others.
Ewa Maria Musiol-Kroll +1 more
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Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins
Nature Communications, 2022 Genetic engineering of the type I polyketide synthases (PKSs) to produce desirable analogous remains largely inefficient. Here, the authors leverage multiple approaches to delete seven internal modules from the stambomycin PKS and generate 37-membered ...
Li Su +8 more
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Metabolic Engineering Communications, 2020 Assembly-line polyketide synthases generate natural products that have led to many live-saving drugs. The use of E. coli as a heterologous host for reconstituting these enormous and complex enzymatic machines has and will continue to be a critical ...
Kai P. Yuet, Chaitan Khosla
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Structure of a modular polyketide synthase [PDF]
Nature, 2014 Polyketide natural products constitute a broad class of compounds with diverse structural features and biological activities. Their biosynthetic machinery, represented by type I polyketide synthases (PKSs), has an architecture in which successive modules catalyse two-carbon linear extensions and keto-group processing reactions on intermediates ...
Dutta, Somnath +10 more
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Synthetic biology of polyketide synthases [PDF]
Journal of Industrial Microbiology and Biotechnology, 2018 Abstract Complex reduced polyketides represent the largest class of natural products that have applications in medicine, agriculture, and animal health. This structurally diverse class of compounds shares a common methodology of biosynthesis employing modular enzyme systems called polyketide synthases (PKSs).
Yuzawa, Satoshi +3 more
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Nature Communications, 2021 Trans-acyltransferase polyketide synthases are multimodular enzymes that synthesise diverse polyketides. Here, the authors present an algorithm for the global study of their diversity, showing exchange of conserved consecutive modules as a driver of ...
Eric J. N. Helfrich +10 more
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Decrypting the programming of β-methylation in virginiamycin M biosynthesis
Nature Communications, 2023 Biosynthesis of complex polyketides by polyketide synthases often relies on trans-acting enzymes to modify the intermediates. Here, the authors elucidate how β-methylation enzymes identify their substrates.
Sabrina Collin +6 more
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Evolution of polyketide synthases in bacteria [PDF]
Proceedings of the National Academy of Sciences, 2008 The emergence of resistant strains of human pathogens to current antibiotics, along with the demonstrated ability of polyketides as antimicrobial agents, provides strong motivation for understanding how polyketide antibiotics have evolved and diversified in nature.
Christian P, Ridley +2 more
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