Results 151 to 160 of about 8,226 (181)
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Polyketide Synthases: Mechanisms and Models
2006The modular structure of the multienzyme PKSs makes them particularly attractive targets for combinatorial biosynthesis aimed at generating novel polyketide medicines. We are beginning to understand those features of subunit organization and structure and their linking and docking elements, which are critical for productive engineering efforts ...
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Fungal type III polyketide synthases
Nat. Prod. Rep., 2014This article covers the literature on fungal type III polyketide synthases (PKSs) published from 2005 to 2014. Since the first discovery of fungal type III PKS genes in Aspergillus oryzae, reported in 2005, putative genes for type III PKSs have been discovered in fungal genomes.
Makoto, Hashimoto +2 more
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Non-modular polyketide synthases in myxobacteria
Phytochemistry, 2009Myxobacteria are prolific producers of a wide variety of secondary metabolites. The vast majority of these compounds are complex polyketides which are biosynthesised by multimodular polyketide synthases (PKSs). In contrast, few myxobacterial metabolites isolated to date are derived from non-modular PKSs, in particular type III PKSs. This review reports
Yanyan, Li, Rolf, Müller
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Novel applications of plant polyketide synthases
Current Opinion in Chemical Biology, 2012The structurally and mechanistically simple type III polyketide synthases (PKSs) catalyze iterative condensations of CoA thioesters to produce a variety of polyketide scaffolds with remarkably diverse structures and biological activities. By exploiting the enzymes, we combined precursor-directed biosynthesis with nitrogen-containing substrates and ...
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Uncovering the structures of modular polyketide synthases
Natural Product Reports, 2015This review covers a breakthrough in the structural biology of the gigantic modular polyketide synthases (PKS): the structural characterization of intact modules by single-particle cryo-electron microscopy and small-angle X-ray scattering.
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The erythromycin-producing polyketide synthase
Biochemical Society Transactions, 1993P F, Leadlay +7 more
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Plant Polyketide Synthases: A fascinating group of enzymes
Plant Physiology and Biochemistry, 2009Robert Verpoorte
exaly
Phylogenetic and Structural Analysis of Polyketide Synthases in Aspergilli
Evolutionary Bioinformatics, 2016Preetida Bhetariya +2 more
exaly