Results 151 to 160 of about 23,262 (184)
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The Chalcone Synthase Superfamily of Type III Polyketide Synthases
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Michael B, Austin, Joseph P, Noel
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Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases
Nature, 1995Modular polyketide synthases (PKSs) are complex multi-enzyme proteins that catalyse the bacterial biosynthesis of many pharmaceutically useful polyketides. The PKSs are organized into a series of modules, each containing the active catalytic sites required for one step in the synthesis process.
R, Pieper, G, Luo, D E, Cane, C, Khosla
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Production of a novel polyketide through the construction of a hybrid polyketide synthase
Gene, 1996The lactone rings of the polyketides platenolide and tylactone are synthesized by condensation of acetate-, proprionate-, and butyrate-derived precursors. A hybrid tylactone/platenolide synthase was constructed to determine if the choice of substrate is programmed by the polyketide synthase and to ascertain if a substrate different than that normally ...
S, Kuhstoss +4 more
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Fungal type III polyketide synthases
Nat. Prod. Rep., 2014This article covers the literature on fungal type III polyketide synthases (PKSs) published from 2005 to 2014. Since the first discovery of fungal type III PKS genes in Aspergillus oryzae, reported in 2005, putative genes for type III PKSs have been discovered in fungal genomes.
Makoto, Hashimoto +2 more
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Non-modular polyketide synthases in myxobacteria
Phytochemistry, 2009Myxobacteria are prolific producers of a wide variety of secondary metabolites. The vast majority of these compounds are complex polyketides which are biosynthesised by multimodular polyketide synthases (PKSs). In contrast, few myxobacterial metabolites isolated to date are derived from non-modular PKSs, in particular type III PKSs. This review reports
Yanyan, Li, Rolf, Müller
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Novel applications of plant polyketide synthases
Current Opinion in Chemical Biology, 2012The structurally and mechanistically simple type III polyketide synthases (PKSs) catalyze iterative condensations of CoA thioesters to produce a variety of polyketide scaffolds with remarkably diverse structures and biological activities. By exploiting the enzymes, we combined precursor-directed biosynthesis with nitrogen-containing substrates and ...
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Uncovering the structures of modular polyketide synthases
Natural Product Reports, 2015This review covers a breakthrough in the structural biology of the gigantic modular polyketide synthases (PKS): the structural characterization of intact modules by single-particle cryo-electron microscopy and small-angle X-ray scattering.
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The erythromycin-producing polyketide synthase
Biochemical Society Transactions, 1993P F, Leadlay +7 more
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Engineered biosynthesis of plant polyketides by type III polyketide synthases in microorganisms
Frontiers in Bioengineering and Biotechnology, 2022Sijin Li
exaly