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Structural control of polyketide formation in plant-specific polyketide synthases [PDF]
Chemistry and Biology, 2000 Polyketide synthases (PKSs) generate molecular diversity by utilizing different starter molecules and by controlling the final length of the polyketide. Although exploitation of this mechanistic variability has produced novel polyketides, the structural foundation of this versatility is unclear. Plant-specific PKSs are essential for the biosynthesis of
Juan Ferrer, Joseph Jez, Joseph Noel
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Biosynthesis of polyketides by trans-AT polyketide synthases
Natural Product Reports, 2010This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that have recently been recognized as one of the major group of proteins involved in the production of bioactive polyketides. 436 references are cited.
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Genetic Contributions to Understanding Polyketide Synthases
Chemical Reviews, 1997David A Hopwood
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Structures and Mechanisms of Polyketide Synthases
The Journal of Organic Chemistry, 2009Nearly a quarter-century ago, the advent of molecular genetic tools in the field of natural product biosynthesis led to the remarkable revelation that the genes responsible for the biosynthesis, regulation, and self-resistance of complex polyketide antibiotics were clustered in the genomes of the bacteria that produced these compounds.
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Manipulation and Analysis of Polyketide Synthases
2004Publisher Summary This chapter examines the manipulation and analysis of polyketide (PKS) synthases. PKS span a large range of medicinally important com-pounds, such as antibiotics, anticancer agents, immunosuppressants, and cholesterol-lowering agents.
Pawan, Kumar, Chaitan, Khosla, Yi, Tang
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Engineering of modular polyketide synthases to produce novel polyketides
Current Opinion in Biotechnology, 1998Polyketides are important natural products produced by Actinomycetes and other organisms via the polymerization of coenzyme A-activated carboxylic acids. Modular polyketide synthases are large multifunctional enzymes that direct the biosynthetic process using a dedicated 'module' for each polymerization reaction, which specifies the unit to be ...
, Carreras, , Santi
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Biosynthesis of polyketides by trans-AT polyketide synthases in Burkholderiales
Critical Reviews in Microbiology, 2019Widely used as drugs and agrochemicals, polyketides are a family of bioactive natural products, with diverse structures and functions. Polyketides are produced by megaenzymes termed as polyketide synthases (PKSs). PKS biosynthetic pathways are divided into the cis-AT PKSs and trans-AT PKSs; a division based mainly on the absence of an acyltransferase ...
Hanna, Chen +10 more
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The Chalcone Synthase Superfamily of Type III Polyketide Synthases
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Michael B, Austin, Joseph P, Noel
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Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases
Nature, 1995Modular polyketide synthases (PKSs) are complex multi-enzyme proteins that catalyse the bacterial biosynthesis of many pharmaceutically useful polyketides. The PKSs are organized into a series of modules, each containing the active catalytic sites required for one step in the synthesis process.
R, Pieper, G, Luo, D E, Cane, C, Khosla
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Production of a novel polyketide through the construction of a hybrid polyketide synthase
Gene, 1996The lactone rings of the polyketides platenolide and tylactone are synthesized by condensation of acetate-, proprionate-, and butyrate-derived precursors. A hybrid tylactone/platenolide synthase was constructed to determine if the choice of substrate is programmed by the polyketide synthase and to ascertain if a substrate different than that normally ...
S, Kuhstoss +4 more
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