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PLoS Pathogens, 2005 Virulent mycobacteria utilize surface-exposed polyketides to interact with host cells, but the mechanism by which these hydrophobic molecules are transported across the cell envelope to the surface of the bacteria is poorly understood.
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Structural control of polyketide formation in plant-specific polyketide synthases [PDF]
Chemistry and Biology, 2000 Polyketide synthases (PKSs) generate molecular diversity by utilizing different starter molecules and by controlling the final length of the polyketide. Although exploitation of this mechanistic variability has produced novel polyketides, the structural foundation of this versatility is unclear. Plant-specific PKSs are essential for the biosynthesis of
Juan Ferrer, Joseph Jez, Joseph Noel
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Manipulation of Modular Polyketide Synthases
Chemical Reviews, 1997Leonard Katz
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Biosynthesis of polyketides by trans-AT polyketide synthases
Natural Product Reports, 2010This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that have recently been recognized as one of the major group of proteins involved in the production of bioactive polyketides. 436 references are cited.
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Structures and Mechanisms of Polyketide Synthases
The Journal of Organic Chemistry, 2009Nearly a quarter-century ago, the advent of molecular genetic tools in the field of natural product biosynthesis led to the remarkable revelation that the genes responsible for the biosynthesis, regulation, and self-resistance of complex polyketide antibiotics were clustered in the genomes of the bacteria that produced these compounds.
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Engineering of modular polyketide synthases to produce novel polyketides
Current Opinion in Biotechnology, 1998Polyketides are important natural products produced by Actinomycetes and other organisms via the polymerization of coenzyme A-activated carboxylic acids. Modular polyketide synthases are large multifunctional enzymes that direct the biosynthetic process using a dedicated 'module' for each polymerization reaction, which specifies the unit to be ...
, Carreras, , Santi
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Manipulation and Analysis of Polyketide Synthases
2004Publisher Summary This chapter examines the manipulation and analysis of polyketide (PKS) synthases. PKS span a large range of medicinally important com-pounds, such as antibiotics, anticancer agents, immunosuppressants, and cholesterol-lowering agents.
Pawan, Kumar, Chaitan, Khosla, Yi, Tang
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Biosynthesis of polyketides by trans-AT polyketide synthases in Burkholderiales
Critical Reviews in Microbiology, 2019Widely used as drugs and agrochemicals, polyketides are a family of bioactive natural products, with diverse structures and functions. Polyketides are produced by megaenzymes termed as polyketide synthases (PKSs). PKS biosynthetic pathways are divided into the cis-AT PKSs and trans-AT PKSs; a division based mainly on the absence of an acyltransferase ...
Hanna, Chen +10 more
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Genetic Contributions to Understanding Polyketide Synthases
Chemical Reviews, 1997David A Hopwood
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Polyketide Synthases: Mechanisms and Models
2006The modular structure of the multienzyme PKSs makes them particularly attractive targets for combinatorial biosynthesis aimed at generating novel polyketide medicines. We are beginning to understand those features of subunit organization and structure and their linking and docking elements, which are critical for productive engineering efforts ...
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