Results 91 to 100 of about 1,395,900 (346)

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Design of an Improved Polymerase Chain Reaction (PCR) Assay for Molecular Detection of Streptococcus pneumonia

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2013
Background and Objectives: Streptococcus pneumoniae accounts for bacterial meningitis and is an important cause of morbidity among children and elderly. Control of this disease depends on rapid detection of the causative bacteria.
Fahimeh Aghamiri, Mohammad Soleimani, Amir Hossein Mohseni, Keivan Majidzade   +3 more
doaj   +2 more sources

Results of Multiplex Polymerase Chain Reaction Assay to Identify Urethritis Pathogens

Journal of Urological Surgery, 2017
Objective: The purpose of this study was to evaluate the results of multiplex polymerase chain reaction (PCR) test applied to identify the pathogens in male patients who attended our urology clinic with a pre-diagnosis of urethritis related with sexual ...
Mehmet Sarıer, İbrahim Duman, Şafak Göktaş, Meltem Demir, Erdal Kukul   +4 more
doaj   +1 more source

Single‐Cell RNA Seq in Sydenham Chorea Shows B Cell HLA‐DR/DQ Upregulation and Plasma Cell Proteasomal Activation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The pathogenesis of Sydenham chorea remains unclear. We report a 10‐year‐old girl presenting with subacute chorea and mild carditis following Streptococcal throat infection. Single‐cell RNA sequencing on 30,794 peripheral immune cells from the patient and two sex‐matched controls revealed nine immune cell clusters.
Velda X. Han, Brooke A. Keating, Brian S. Gloss, Xianzhong Lau, Ruwani Dissanayake, Hiroya Nishida, Jessica Hayes, Shrujna Patel, Shekeeb S. Mohammad, Russell C. Dale   +9 more
wiley   +1 more source

DIAGNOSIS OF CANINE TRYPANOSOMOSIS BY POLYMERASE CHAIN REACTION [PDF]

Journal of Veterinary and Animal Sciences, 2013
A clinical case of trypanosomosis in a German Shepherd dog and its diagnosis by polymerase chain reaction(PCR) was described.The dog was presented with clinical signs such as pyrexia, bilateral corneal opacity, pale mucous membranes, emaciation and ...
P.V.Tresamol, N.P. Usha, T.V. Aravindakshan, Reji Varghese, M.R. Saseendranath   +4 more
doaj  

Development of Polymerase Chain Reaction assays with host-specific internal controls for Chlamydophila abortus

Veterinární Medicína, 2015
Chlamydophila abortus (C. abortus) is one of the most important infectious agents causing abortion in ruminants. The bacterium is obligately intracellular, cannot grow on agar, but it needs cell culture or embryonated eggs for growth.
Z. Cantekin, H. Solmaz, Y. Ergun, M. Ozmen   +3 more
doaj   +1 more source

Long COVID in People With Multiple Sclerosis and Related Disorders: A Multicenter Cross‐Sectional Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Managing long COVID in people with multiple sclerosis and related disorders (pwMSRD) is complex due to overlapping symptoms. To address evidence gaps, we evaluated long COVID susceptibility in pwMSRD versus controls and its associations with multi‐domain function and disability.
Chen Hu, Jiyeon Son, Lindsay McAlpine, Elizabeth L. S. Walker, Megan Dahl, Emily Song, Sugeidy Ferreira Brito, Katelyn Kavak, Kaho Onomichi, Amit Bar‐Or, Christopher Perrone, Claire S. Riley, Bianca Weinstock‐Guttman, Philip L. De Jager, Erin E. Longbrake, Zongqi Xia   +15 more
wiley   +1 more source

Multiplexed reverse-transcriptase quantitative polymerase chain reaction using plasmonic nanoparticles for point-of-care COVID-19 diagnosis

Nature Nanotechnology, 2022
Nicole R. Blumenfeld, Michael Anne E. Bolene, Martin Jaspan, Abigail G. Ayers, Sabin Zarrandikoetxea, Juliet Freudman, Nikhil Shah, Angela M. Tolwani, Yuhang Hu, Terry L. Chern, James Rogot, Vira Behnam, Aditya Sekhar, Xinyi Liu, Bulent Onalir, Robert T. Kasumi, Abdoulaye Sanogo, Kelia Human, Kasey Murakami, Goutham S. Totapally, Mark Fasciano, S. Sia   +21 more
semanticscholar   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Direct method for detecting small quantities of hepatitis B virus DNA in serum and plasma using the polymerase chain reaction. [PDF]

, 1989
Jerome B. Zeldis, J H Lee, D. Mamish, D J Finegold, Reema Sircar, Qiu Ling, Peter Juel Thiis Knudsen, I. K. Kuramoto, Larry Mimms   +8 more
openalex   +1 more source