Results 121 to 130 of about 34,466 (298)

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

PEG-b-PCL polymeric nano-micelle inhibits vascular angiogenesis by activating p53-dependent apoptosis in zebrafish

International Journal of Nanomedicine, 2016
Tian Zhou,1 Qinglei Dong,1 Yang Shen,2 Wei Wu,1 Haide Wu,1 Xianglin Luo,3 Xiaoling Liao,4 Guixue Wang1 1Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants,
Zhou T, Dong Q, Shen Y, Wu W, Wu H, Luo X, Liao X, Wang G   +7 more
doaj  

Synthesis and in vitro evaluation of self-assembling biocompatible heparin-based targeting polymeric micelles for delivery of doxorubicin to leukemic cells

Research in Pharmaceutical Sciences
Background and purpose: Biodegradable polymeric micelles have emerged as one of the most promising platforms for targeted drug delivery. In the present study, a polymeric micelle composed of folic acid (FA), heparin (HEP), dexamethasone (DEX), and (FA ...
Jaber Emami, Moloud Kazemi, Mina Mirian
doaj   +1 more source

Controlled Fab installation onto polymeric micelle nanoparticles for tuned bioactivity

Science and Technology of Advanced Materials, 2017
Antibodies and antigen-binding fragments (Fabs) can be used to modify the surface of nanoparticles for enhanced target binding. In our previous work, site-specific conjugation of Fabs to polymeric micelles using conventional methods was limited to ...
Shaoyi Chen, Stelios Florinas, Abigail Teitgen, Ze-Qi Xu, Changshou Gao, Herren Wu, Kazunori Kataoka, Horacio Cabral, R. James Christie   +8 more
doaj   +1 more source

Parasitological and immunological evaluation of a quinoline derivative salt incorporated into a polymeric micelle formulation against Leishmania infantum infection. [PDF]

Parasitol Res, 2022
Ribeiro Antinarelli LM, Glanzmann N, Mendonça DVC, Lage DP, Oliveira-da-Silva JA, Tavares GSV, Carvalho AMRS, Freitas CS, Martins VT, Duarte MC, Menezes-Souza D, da Silva AD, Coelho EAF, Soares Coimbra E.   +13 more
europepmc   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source

A Multifunctional Polymeric Micelle for Targeted Delivery of Paclitaxel by the Inhibition of the P-Glycoprotein Transporters. [PDF]

Nanomaterials (Basel), 2021
Razzaq S, Rauf A, Raza A, Akhtar S, Tabish TA, Sandhu MA, Zaman M, Ibrahim IM, Shahnaz G, Rahdar A, Díez-Pascual AM.   +10 more
europepmc   +1 more source

A Self‐Organized Liquid Reaction Container for Cellular Memory

Advanced Science, EarlyView.
How cells restore epigenetic information lost during replication is not known. This work proposes a mechanism based on the formation of biomolecular condensates. These condensates are induced by the chromosome itself and serve as reaction vessels for reconstructing missing epigenetic markers.
Sukanta Mukherjee, Enrico Skoruppa, Holger Merlitz, Jens‐Uwe Sommer, Helmut Schiessel   +4 more
wiley   +1 more source

Multispectral optoacoustic tomography (MSOT) for imaging the particle size-dependent intratumoral distribution of polymeric micelles

International Journal of Nanomedicine, 2018
Zhaoqing Cong, Feifei Yang, Li Cao, Han Wen, Taotao Fu, Siqi Ma, Chunyu Liu, Lihui Quan, Yonghong Liao Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy
Cong ZQ, Yang FF, Cao L, Wen H, Fu TT, Ma SQ, Liu CY, Quan LH, Liao YH   +8 more
doaj  

Preparation and Characterization of Olmesartan Medoxomil-Loaded Polymeric Mixed Micelle Nanocarrier

Iraqi Journal of Pharmaceutical Sciences
Olmesartan medoxomil (OLM) is a selective angiotensin II antagonist that effectively lowers blood pressure. It has a poor rate of absorption when taken orally, a maximum bioavailability of about 26%, and limited solubility in water.
Halah Talal Sulaiman , Nawal A. Rajab
doaj   +1 more source