Results 81 to 90 of about 482,977 (308)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Polymerization-Induced Self-Assembly Promoted by Liquid–Liquid Phase Separation
, 2019 Polymerization-induced self-assembly (PISA) is a powerful method for the synthesis of polymeric kinetically frozen core nanoparticles. However, the PISA synthesis of biologically important polymeric fluidic materials is unexplored.
Yi Ding (172783) +6 more
core +3 more sources
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Uniqueness of Supramolecular Systems
Macromolecular Materials and EngineeringStructural innovation requires molecular diversity, and new applications arising from life's challenges demand materials and systems that fulfill a wide range of functions. While supramolecular materials have long been a fundamental source of inspiration
José A. Sánchez‐Fernández
doaj +1 more source
Data in Brief, 2019 The present article contains the data of tensile stress-strain curves, crosslinking characteristics curves, filler dispersion images and dynamic mechanical properties of SSBR/BR blends and SSBR/BR/SiO2 composites during room-temperature annealing.
Xinping Zhang +3 more
doaj +1 more source
Polymerization of Cycloolefines
Kobunshi Kagaku, 1969 1, 3-シクロオクタジエソ (1, 3-COD) と液体亜硫酸 (SO2) との共重合について検討した。1, 3-CODはAgNO3, H2O2などの添加によりSO2と共重合し, DMF, DMSOおよびSO2に可溶な1: 1組成のポリスルポソを与える。共役二重結合へのSO2の付加は主に1, 2-付加であろうと推定した。AgNO3を触媒とし, 過剰のSO2中で重合を行なった場合共重合初速度はAgNO3初濃度の1/2乗に比例し (0℃), 活性化エネルギーは約8.5kcal/mol (-10-+15℃) であった。重合初速度は約20℃に極大を有し, それ以上の温度では急激に低下し, 天井温度が35-40℃付近に存在することがわかった ([1, 3-COD] 0・[SO2] 0=10mol2/l2 ...
Tadashi Yamaguchi, Katsutoshi Nagai
openaire +3 more sources
Synthesis and application of some novel functional polymers via controlled radical polymerization and click chemistry [PDF]
The objective of this thesis was to prepare thermoresponsive PEG-based homopolymers and copolymers by combination of cobalt-mediated catalytic chain-transfer polymerization (CCTP) and thiol-ene “click” chemistry and prepare well-defined glycopolymers ...
Li, Guang-Zhao
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source