Results 141 to 150 of about 3,285 (181)
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Annual Review of Biomedical Engineering, 2006
Polymersomes are self-assembled polymer shells composed of block copolymer amphiphiles. These synthetic amphiphiles have amphiphilicity similar to lipids, but they have much larger molecular weights, so for this reason—along with others reviewed here—comparisons of polymersomes with viral capsids composed of large polypeptide chains are highly ...
Discher, Dennis E, Ahmed, Fariyal
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Polymersomes are self-assembled polymer shells composed of block copolymer amphiphiles. These synthetic amphiphiles have amphiphilicity similar to lipids, but they have much larger molecular weights, so for this reason—along with others reviewed here—comparisons of polymersomes with viral capsids composed of large polypeptide chains are highly ...
Discher, Dennis E, Ahmed, Fariyal
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Polymersomes in Polymersomes: Multiple Loading and Permeability Control
Angewandte Chemie International Edition, 2011With such a compartmentalized structure, a mol-ecule encapsulated in the inner liposome, would have topermeate through two successive membranes, instead of asingle one before leaking into the outside environment. Thisdouble-membrane effect was demonstrated by observing theserumhalf-lifeofciprofloxacindrugincreasingfrom10 mininsingle liposomes to 6 h in
Maïté, Marguet +2 more
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Polymersomes: Preparation and Characterization
2019Polymersomes, also called polymeric vesicles, are self-assembled by amphiphilic copolymers. Due to their unique characters, polymersomes are attracting more and more interest as an important class of vehicles for nanopharmaceuticals. In this chapter, various methods to prepare and characterize polymersomes are introduced systematically with several ...
Yumiao, Hu, Liyan, Qiu
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Detergent-Aided Polymersome Preparation
Biomacromolecules, 2010Until now, most preparative methods used to form polymeric vesicles involve either organic cosolvents or sonication. In this communication, we demonstrate for the first time a detergent-aided method to produce polymersomes. Peptidic polymersomes were formed from the rod-rod block copolymer PBLG(36)-E, where PBLG is hydrophobic poly(gamma-benzyl l ...
Marsden H. R. +5 more
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J. Mater. Chem. B, 2014
A multicompartment cascade reaction is presented in a polymersome-in-polymersome architecture, which is regulated by insertion of a channel protein in the inner compartment's polymer membrane.
Winna, Siti +6 more
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A multicompartment cascade reaction is presented in a polymersome-in-polymersome architecture, which is regulated by insertion of a channel protein in the inner compartment's polymer membrane.
Winna, Siti +6 more
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Nachrichten aus der Chemie, 2012
AbstractPolymersome sind artifizielle Strukturen, die das Bauprinzip der Liposomen nutzen. Sie eignen sich unter anderem als Wirkstofftransporter und als Nanoreaktoren für Biomedizin und Biotechnik.
Jens Gaitzsch +2 more
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AbstractPolymersome sind artifizielle Strukturen, die das Bauprinzip der Liposomen nutzen. Sie eignen sich unter anderem als Wirkstofftransporter und als Nanoreaktoren für Biomedizin und Biotechnik.
Jens Gaitzsch +2 more
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Journal of Drug Delivery Science and Technology, 2013
In spite of the clear potential of personalized medicine, its pace of implementation has not yet fulfilled initial hopes. Polymeric vesicles, also named polymersomes, are presented as versatile systems able to address issues of efficacy, specificity and controlled release of drugs in a wide range of pathological scenarios that might show the way to ...
J. Thevenot +2 more
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In spite of the clear potential of personalized medicine, its pace of implementation has not yet fulfilled initial hopes. Polymeric vesicles, also named polymersomes, are presented as versatile systems able to address issues of efficacy, specificity and controlled release of drugs in a wide range of pathological scenarios that might show the way to ...
J. Thevenot +2 more
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Sequential Synthesis of Coordination Polymersomes
Angewandte Chemie International Edition, 2014AbstractNovel organic–inorganic hybrid liposomes, so‐called coordination polymersomes (CPsomes), with artificial domains that exhibit strong lateral cohesion were prepared by a three‐step procedure that formed a coordinative interaction leading to a lipid bilayer.
Ryo, Ohtani +6 more
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2013
Amphiphilic block copolymers represent a major field of research in the design and creation of innovative materials for biomedical applications. Self-directed assemblies of such copolymers have been of great value in the development of novel drug delivery systems.
Núria Sancho Oltra +5 more
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Amphiphilic block copolymers represent a major field of research in the design and creation of innovative materials for biomedical applications. Self-directed assemblies of such copolymers have been of great value in the development of novel drug delivery systems.
Núria Sancho Oltra +5 more
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Covalent Attachment of Polymersomes to Surfaces
Langmuir, 2010We show that vesicles made of block copolymers with aldehyde end groups can be covalently attached to aminated and non-aminated, untreated glass surfaces. The attached vesicles were sufficiently stable to allow a detailed investigation of vesicle shapes by confocal laser scanning microscopy (CLSM) and AFM in aqueous solutions allowing reconstruction of
Stephanie, Domes +4 more
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