Engineered Hybrid Vesicles and Cellular Internalization in Mammary Cancer Cells [PDF]
PharmaceuticsExtracellular vesicles play an important role in intercellular communication, with the potential to serve as biomaterials for nanocarriers. Combining such extracellular vesicles and liposomes results in advanced drug delivery carriers.
So Yun Kim +5 more
doaj +4 more sources
Characterization of Gramicidin A in Triblock and Diblock Polymersomes and Hybrid Vesicles via Continuous Wave Electron Paramagnetic Resonance Spectroscopy [PDF]
BiomimeticsStudying membrane proteins in a native environment is crucial to understanding their structural and/or functional studies. Often, widely accepted mimetic systems have limitations that prevent the study of some membrane proteins.
Emma A. Gordon +3 more
doaj +2 more sources
Optimization of Innovative Three-Dimensionally-Structured Hybrid Vesicles to Improve the Cutaneous Delivery of Clotrimazole for the Treatment of Topical Candidiasis [PDF]
Pharmaceutics, 2019 New three-dimensionally-structured hybrid phospholipid vesicles, able to load clotrimazole in a high amount (10 mg/mL), were obtained for the first time in this work by significantly reducing the amount of water (≤10%), which was replaced with a ...
Maria Letizia Manca +10 more
doaj +2 more sources
Engineered vesicles enhance oral antibiotic absorption in proximal small intestine and mitigate gut dysbiosis [PDF]
Nature CommunicationsOral antibiotics are a mainstay for treating bacterial infections, but unabsorbed portions can reach the caecum and colon, leading to gut dysbiosis. Herein, we engineer a biohybrid delivery system through the integration of milk extracellular vesicles ...
Yinglan Yu +8 more
doaj +2 more sources
Multifunctional vesicles in cancer therapy and theranostics: current advances and future challenges [PDF]
Journal of NanobiotechnologyNanocarriers have revolutionized the field of cancer therapeutics by enhancing the delivery and efficacy of anticancer agents. This paper explores the various types of multifunctional vesicles utilized in cancer treatment, including non-biological ...
Fatemeh Araste +2 more
doaj +2 more sources
Neutrophil-mediated delivery of hybrid cross-species nanovesicles for treatment of bacterial infections [PDF]
Nature CommunicationsHybrid vesicles are increasingly employed as nanocarrier systems for drug delivery owing to their versatile functionalities. This study presents a multifunctional vesicle delivery platform, designated PMB@LNV-SyBV, which integrates anti-inflammatory ...
Hanqing Li +9 more
doaj +2 more sources
Carbon Dots and Biomimetic Membrane Systems: Mechanistic Interactions and Hybrid Nano-Lipid Platforms [PDF]
NanomaterialsCarbon dots (CDs) have emerged as a distinct class of fluorescent nanomaterials distinguished by their tunable physicochemical properties, ultrasmall size, exceptional photoluminescence, versatile surface chemistry, high biocompatibility, and chemical ...
Nisreen Nusair, Mithun Bhowmick
doaj +2 more sources
A spatiotemporal selective bioinspired hybrid system engineered for preventing post-thrombolysis recurrence by inhibiting the ferroptosis pathway and reprogramming macrophages [PDF]
Acta Pharmaceutica Sinica BCardiovascular diseases induced by arterial thrombosis, such as myocardial infarction and ischemic stroke, have gradually emerged as critical threats to human life and health.
Tianjiao Hao +9 more
doaj +2 more sources
Smart Vesicle Therapeutics: Engineering Precision at the Nanoscale [PDF]
PharmaceuticsSmart vesicle therapeutics represent a transformative frontier in nanomedicine, offering precise, biocompatible, and adaptable platforms for drug delivery and theranostic applications. This review explores recent advances in the design and engineering of
Luciano A. Benedini, Paula V. Messina
doaj +2 more sources
Dual-targeted hybrid nanovesicles coordinated bone-muscle regeneration via regulating the DUSP4/p38 MAPK pathway to reverse osteosarcopenia [PDF]
Journal of NanobiotechnologyOsteosarcopenia (OSP), a degenerative syndrome characterized by concurrent osteoporosis and sarcopenia, exhibits persistently high global prevalence due to aging and disuse, yet lacks targeted therapies.
Benchi Che +11 more
doaj +2 more sources