Results 21 to 30 of about 88,475 (282)

Extracellular Vesicle-Based Hybrid Systems for Advanced Drug Delivery [PDF]

Pharmaceutics, 2022
The continuous technological advancement of nanomedicine has enabled the development of novel vehicles for the effective delivery of therapeutic substances. Synthetic drug delivery systems are nano-sized carriers made from various materials that can be designed to deliver therapeutic cargoes to cells or tissues.
Rodríguez, Diego A., Vader, Pieter
openaire   +4 more sources

Membrane composition of polymer-lipid hybrid vesicles

Applied Materials Today, 2022
Hybrid vesicles (HVs) assembled from phospholipids and amphiphilic block copolymers (BCPs) are a more recent alternative to liposomes and polymersomes. We aim to change the properties of the HV membranes by varying the chemical composition of the hydrophobic block in the BCPs that have poly(carboxyethyl acrylate) (PCEA) as the hydrophilic part. To this
Brodszkij, Edit, Westensee, Isabella Nymann, Holleufer, Steffen Friis, Ade, Carina, Andres, Paula De Dios, Pedersen, Jan Skov, Städler, Brigitte   +6 more
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Hybrid giant lipid vesicles incorporating a PMMA-based copolymer [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2021
In recent years, there has been a growing interest in the formation of copolymer-lipid hybrid self-assemblies, which allow combining and improving the main features of pure lipid-based and copolymer-based systems known for their potential applications in the biomedical field.
Miele, Ylenia, Mingotaud, Anne-Françoise, Caruso, Enrico, Malacarne, Miryam, Izzo, Lorella, Lonetti, Barbara, Rossi, Federico   +6 more
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Cell membrane-derived vesicles for delivery of therapeutic agents

Acta Pharmaceutica Sinica B, 2021
Cell membranes have recently emerged as a new source of materials for molecular delivery systems. Cell membranes have been extruded or sonicated to make nanoscale vesicles. Unlike synthetic lipid or polymeric nanoparticles, cell membrane-derived vesicles
Quoc-Viet Le, Jaiwoo Lee, Hobin Lee, Gayong Shim, Yu-Kyoung Oh   +4 more
doaj   +1 more source

Astrocytes in Paper Chips and Their Interaction with Hybrid Vesicles [PDF]

Advanced Biology, 2022
AbstractThe role of astrocytes in brain function has received increased attention lately due to their critical role in brain development and function under physiological and pathophysiological conditions. However, the biological evaluation of soft material nanoparticles in astrocytes remains unexplored.
Abild Meyer, Cathrine, De Dios Andres, Paula, Brodszkij, Edit, Westensee, Isabella N., Lyons, Joseph, Vaz, Sandra H., Städler, Brigitte   +6 more
openaire   +3 more sources

Entropy-driven segregation and budding in hybrid vesicles of binary nanoparticle amphiphiles

Giant, 2020
Self-assembly of giant building blocks beyond conventional molecules offers tremendous opportunities for the fabrication of new-generation structural materials.
Chelsey Lamar, Yijing Liu, Chenglin Yi, Zhihong Nie   +3 more
doaj   +1 more source

Application of lipid nanovesicle drug delivery system in cancer immunotherapy

Journal of Nanobiotechnology, 2022
Immunotherapy has gradually emerged as the most promising anticancer therapy. In addition to conventional anti-PD-1/PD-L1 therapy, anti-CTLA-4 therapy, CAR-T therapy, etc., immunotherapy can also be induced by stimulating the maturation of immune cells ...
Yinan Ding, Luhong Wang, Han Li, Fengqin Miao, Zhiyuan Zhang, Chunmei Hu, Weiping Yu, Qiusha Tang, Guoliang Shao   +8 more
doaj   +1 more source

Hybrid lipopolymer vesicle drug delivery and release systems

The Journal of Biomedical Research, 2021
Hybrid lipopolymer vesicles are membrane vesicles that can be self-assembled on both the micro- and nano-scale. On the nanoscale, they are potential novel smart materials for drug delivery systems that could combine the relative strengths of liposome and polymersome drug delivery systems without their respective weaknesses.
Reimhult, Erik, Virk, Mudassar Mumtaz
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Functional siRNA Delivery by Extracellular Vesicle–Liposome Hybrid Nanoparticles [PDF]

Advanced Healthcare Materials, 2021
AbstractThe therapeutic use of RNA interference is limited by the inability of siRNA molecules to reach their site of action, the cytosol of target cells. Lipid nanoparticles, including liposomes, are commonly employed as siRNA carrier systems to overcome this hurdle, although their widespread use remains limited due to a lack of delivery efficiency ...
Evers, Martijn J. W., van de Wakker, Simonides I., de Groot, Ellis M., de Jong, Olivier G., Gitz‐François, Jerney J. J., Seinen, Cor S., Sluijter, Joost P. G., Schiffelers, Raymond M., Vader, Pieter   +8 more
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Extracellular vesicles hybrid plasmid-loaded lipid nanovesicles for synergistic cancer immunotherapy

Materials Today Bio, 2023
Combination immunotherapy of cancer vaccines with immune checkpoint inhibitors (ICIs) represents a promising therapeutic strategy for immunosuppressed and cold tumors.
Qing Tong, Kexin Li, Fanwei Huang, Yun Dai, Tao Zhang, Munawaer Muaibati, Abasi Abuduyilimu, Xiaoyuan Huang   +7 more
doaj   +1 more source