Click Chemistry in Polymersome Technology [PDF]
PharmaceuticalsPolymersomes, self-assembled nanoparticles composed of amphiphilic block copolymers, have emerged as promising versatile nanovesicles with various applications, such as drug delivery, medical imaging, and diagnostics.
Costa P +2 more
exaly +6 more sources
Hallmarks of Polymersome Characterization [PDF]
ACS Materials AuPolymersomes have the potential to become the next generation of vesicular drug delivery systems. Their high chemical versatility and in certain cases higher membrane stability than liposomes raised the high hopes for polymersomes as a drug carrier, but the clinical translation has been slow.
Simon Matoori
doaj +4 more sources
Polymersome-based nanomedicine for combined cancer therapy [PDF]
Drug DeliveryCancer is a complex disease characterized by uncontrolled cell growth and spread, often resulting in metastasis. The use of combination therapy, which involves the simultaneous application of two or more treatment methods, aims to enhance effectiveness ...
Aidin Mohammadi Zonouz +7 more
doaj +2 more sources
Pharmaceutics, 2022 Dengue remains a severe threat to public health. The safety and efficacy of the licensed dengue vaccine is not clinically satisfactory, which necessitate the need of new approach in designing an effective dengue vaccine without eliciting adverse reaction.
Mohd Cairul Iqbal Mohd Amin +2 more
exaly +3 more sources
Metformin-loaded J-AuPPS for infected diabetic wound treatment [PDF]
Frontiers in Bioengineering and BiotechnologyIntroductionInfected diabetic wounds pose a significant clinical challenge owing to the complex wound microenvironment. Various multifunctional synergistic therapeutic nanomaterials have been successfully developed to treat diabetic infected wounds ...
Fuli Yin +5 more
doaj +2 more sources
ENT‐1‐Targeted Polymersomes to Enhance the Efficacy of Methotrexate in Choriocarcinoma Treatment [PDF]
Small ScienceGestational choriocarcinoma (CC) is a rare and highly malignant cancer originating from the trophoblastic layers of the placenta. Currently, methotrexate (MTX) is the first‐line treatment for CC; however, due to the aggressive and metastatic nature of CC,
Babak Mamnoon +10 more
doaj +2 more sources
Oral microbiota-regulating and inflammation-targeted polymersome-hydrogels for RNAi therapy of ulcerative colitis [PDF]
Bioactive MaterialsThe treatment of ulcerative colitis is harassed by its intricate pathogenesis and the harsh gastrointestinal environment. Herein, oral microbiota-regulating and inflammation-targeted polymersome-hydrogels are developed by incorporating gallic acid and ...
Huan He +7 more
doaj +2 more sources
Tunable Intranasal Polymersome Nanocarriers Triggered Olanzapine Brain Delivery and Improved In Vivo Antipsychotic Activity [PDF]
PharmaceuticsBackground: Olanzapine (Ola) is a second-generation antipsychotic with clinical utility limited by poor brain bioavailability due to blood–brain barrier restriction, hepatic first-pass metabolism, and systemic side effects.
Ahmed A. Katamesh +9 more
doaj +2 more sources
PANC-1 cancer stem-like cell death with silybin encapsulated in polymersomes and deregulation of stemness-related miRNAs and their potential targets [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Cancer stem cells (CSCs) have powerful self-renewal ability and tumor recurrence. Pancreatic ductal adenocarcinoma is a malignancy with high mortality rate and ˃5% survival. Silybin has anticancer and hepatoprotective properties.
Fatemeh Tehrani +3 more
doaj +1 more source
Morphological Diversity in Diblock Copolymer Solutions: A Molecular Dynamics Study
Colloids and Interfaces, 2023 Coarse-grained molecular dynamics simulations that incorporate explicit water-mediated hydrophilic/hydrophobic interactions are employed to track spatiotemporal evolution of diblock copolymer aggregation in initially homogeneous solutions.
Senyuan Liu, Radhakrishna Sureshkumar
doaj +1 more source