Results 11 to 20 of about 3,624 (199)
Bio-Inspired Polymersome Nanoreactors [PDF]
CHIMIA, 2019 : Two key concepts in living organisms are that biochemical reactions are sequestered into reaction compartments such as cells and organelles, and that many of the complex biological reaction cascades involve transient activation of reactions in response
Omar Rifaie-Graham +2 more
doaj +5 more sources
Hydrogels Incorporating Donor-Acceptor Stenhouse Adducts as a Platform for Photoinduced, On-Off Switchable Release of Small Molecule Cargos. [PDF]
Macromol Rapid CommunDonor–acceptor Stenhouse aDdducts (DASAs) are known for their photoinduced tautomerization, which, when conjugated to block copolymers, can self‐assemble into tuneable polymersomes. These DASA‐polymersomes are being investigated for light‐controlled cargo release in biomedical applications.
Dell TN +10 more
europepmc +2 more sources
Redox-Responsive Polymersomes as Smart Doxorubicin Delivery Systems
Pharmaceutics, 2022 Stimuli-responsive polymersomes have emerged as smart drug delivery systems for programmed release of highly cytotoxic anticancer agents such as doxorubicin hydrochloride (Dox·HCl).
Carmen Ferrero +2 more
doaj +1 more source
Charge-Complementary Polymersomes for Enhanced mRNA Delivery
Pharmaceutics, 2023 Messenger RNA (mRNA) therapies have emerged as potent and personalized alternatives to conventional DNA-based therapies. However, their therapeutic potential is frequently constrained by their molecular instability, susceptibility to degradation, and ...
HakSeon Kim +5 more
doaj +1 more source
Development of Polymersomes Co-Delivering Doxorubicin and Melittin to Overcome Multidrug Resistance
Molecules, 2023 Multidrug resistance (MDR) is one of the major barriers in chemotherapy. It is often related to the overexpression of efflux receptors such as P-glycoprotein (P-gp).
Eunkyung Han +5 more
doaj +1 more source
Journal of the American Chemical Society, 2023 The contents of biological cells are retained within compartments formed of phospholipid membranes. The movement of material within and between cells is often mediated by the fusion of phospholipid membranes, which allows mixing of contents or excretion of material into the surrounding environment.
Stephen D. P. Fielden +4 more
openaire +2 more sources
PANC-1 cancer stem-like cell death with silybin encapsulated in polymersomes and deregulation of stemness-related miRNAs and their potential targets [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Cancer stem cells (CSCs) have powerful self-renewal ability and tumor recurrence. Pancreatic ductal adenocarcinoma is a malignancy with high mortality rate and ˃5% survival. Silybin has anticancer and hepatoprotective properties.
Fatemeh Tehrani +3 more
doaj +1 more source
Faraday Discussions, 2008 Polymersomes are vesicles whose membranes are comprised of self-assembled amphiphilic block co-polymers. Synthetic control of block co-polymer chemistry provides an advantageous diversity of polymersome functions, ranging from tunable materials strength, superior encaspulation of hydrophobic and hydrophilic drugs and optical dyes, and facile ...
Daniel A, Hammer +8 more
openaire +2 more sources
Molecules, 2022 Limited tissue selectivity and targeting of anticancer therapeutics in systemic administration can produce harmful side effects in the body. Various polymer nano-vehicles have been developed to encapsulate therapeutics and prevent premature drug release.
Veronika Kozlovskaya +6 more
doaj +1 more source
Polymersomes Eradicating Intracellular Bacteria [PDF]
ACS Nano, 2020 Mononuclear phagocytes such as monocytes, tissue-specific macrophages, and dendritic cells are primary actors in both innate and adaptive immunity. These professional phagocytes can be parasitized by intracellular bacteria, turning them from housekeepers to hiding places and favoring chronic and/or disseminated infection.
Fenaroli F. +18 more
openaire +6 more sources