Results 21 to 30 of about 2,445 (197)

Dually Responsive Poly(N-vinylcaprolactam)-b-poly(dimethylsiloxane)-b-poly(N-vinylcaprolactam) Polymersomes for Controlled Delivery

Molecules, 2022
Limited tissue selectivity and targeting of anticancer therapeutics in systemic administration can produce harmful side effects in the body. Various polymer nano-vehicles have been developed to encapsulate therapeutics and prevent premature drug release.
Veronika Kozlovskaya, Yiming Yang, Fei Liu, Kevin Ingle, Aftab Ahmad, Ganesh V. Halade, Eugenia Kharlampieva   +6 more
doaj   +1 more source

PANC-1 cancer stem-like cell death with silybin encapsulated in polymersomes and deregulation of stemness-related miRNAs and their potential targets [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Cancer stem cells (CSCs) have powerful self-renewal ability and tumor recurrence. Pancreatic ductal adenocarcinoma is a malignancy with high mortality rate and ˃5% survival. Silybin has anticancer and hepatoprotective properties.
Fatemeh Tehrani, Najmeh Ranji, Fatemeh Kouhkan, Simzar Hosseinzadeh   +3 more
doaj   +1 more source

Leuko-polymersomes [PDF]

Faraday Discussions, 2008
Polymersomes are vesicles whose membranes are comprised of self-assembled amphiphilic block co-polymers. Synthetic control of block co-polymer chemistry provides an advantageous diversity of polymersome functions, ranging from tunable materials strength, superior encaspulation of hydrophobic and hydrophilic drugs and optical dyes, and facile ...
Daniel A, Hammer, Gregory P, Robbins, Jered B, Haun, John J, Lin, Wei, Qi, Lee A, Smith, P Peter, Ghoroghchian, Michael J, Therien, Frank S, Bates   +8 more
openaire   +2 more sources

Polymersomes in “Gelly” Polymersomes: Toward Structural Cell Mimicry [PDF]

Langmuir, 2011
We demonstrate here the formation of compartmentalized polymersomes with an internal "gelly" cavity using an original and versatile process. Nanosize polymersomes of poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA), formed by a solvent displacement method are encapsulated with a rough "cytoplasm mimic" in giant polymersomes of poly ...
Marguet, Maïté, Sandre, Olivier, Lecommandoux, Sébastien   +2 more
openaire   +4 more sources

Morphogenesis of starfish polymersomes

Nature Communications, 2023
Abstract The enhanced membrane stability and chemical versatility of polymeric vesicles have made them promising tools in micro/nanoreactors, drug delivery, cell mimicking, etc. However, shape control over polymersomes remains a challenge and has restricted their full potential.
Jiawei Sun, Sandra Kleuskens, Jiabin Luan, Danni Wang, Shaohua Zhang, Wei Li, Gizem Uysal, Daniela A. Wilson   +7 more
openaire   +5 more sources

Polymersomes Eradicating Intracellular Bacteria [PDF]

ACS Nano, 2020
Mononuclear phagocytes such as monocytes, tissue-specific macrophages, and dendritic cells are primary actors in both innate and adaptive immunity. These professional phagocytes can be parasitized by intracellular bacteria, turning them from housekeepers to hiding places and favoring chronic and/or disseminated infection.
Federico Fenaroli, James D. Robertson, Edoardo Scarpa, Virginia M. Gouveia, Claudia Di Guglielmo, Cesare De Pace, Philip M. Elks, Alessandro Poma, Dimitrios Evangelopoulos, Julio Ortiz Canseco, Tomasz K. Prajsnar, Helen M. Marriott, David H. Dockrell, Simon J. Foster, Timothy D. McHugh, Stephen A. Renshaw, Josep Samitier Martí, Giuseppe Battaglia, Loris Rizzello   +18 more
openaire   +6 more sources

Polymersome-based nanomotors: preparation, motion control, and biomedical applications. [PDF]

Chem Sci
Polymersome-based nanomotors represent a cutting-edge development in nanomedicine, merging the unique vesicular properties of polymersomes with the active propulsion capabilities of synthetic nanomotors.
Song S, Han H, Wang J, Pu Y, Shao J, Xie J, Che H, van Hest JCM, Cao S.   +8 more
europepmc   +2 more sources

DENV-Mimetic Polymersome Nanoparticles Bearing Multi-Epitope Lipopeptides Antigen as the Next-Generation Dengue Vaccine

Pharmaceutics, 2022
Dengue remains a severe threat to public health. The safety and efficacy of the licensed dengue vaccine is not clinically satisfactory, which necessitate the need of new approach in designing an effective dengue vaccine without eliciting adverse reaction.
Nur Adilah Abdul Rahman, Abdin Shakirin Mohamad Norpi, Muhammad Luqman Nordin, Mohd Cairul Iqbal Mohd Amin, Abdullah Al-Hadi Ahmad Fuaad, Nor Azila Muhammad Azami, Nirmal Marasini, Fazren Azmi   +7 more
doaj   +1 more source

Paramagnetic Porous Polymersomes [PDF]

Langmuir, 2008
The ability of chelated Gd to serve as an effective magnetic resonance (MR) contrast agent largely depends on fast exchange rates between the Gd-bound water molecules and the surrounding bulk water. Because water diffuses slowly across lipid bilayers, liposomes with encapsulated chelated Gd have not been widely adopted as MR contrast agents.
Cheng, Zhiliang, Tsourkas, Andrew
openaire   +2 more sources

Triggered Polymersome Fusion

Journal of the American Chemical Society, 2023
The contents of biological cells are retained within compartments formed of phospholipid membranes. The movement of material within and between cells is often mediated by the fusion of phospholipid membranes, which allows mixing of contents or excretion of material into the surrounding environment.
Stephen D. P. Fielden, Matthew J. Derry, Alisha J. Miller, Paul D. Topham, Rachel K. O’Reilly   +4 more
openaire   +2 more sources