Results 41 to 50 of about 1,447 (174)
Development of a Polymersome Blood Ammonia Assay Coupled with a Portable Near-Infrared Fluorometer [PDF]
ACS Bio & Med Chem AuMarie-Lynn Al-Hawat +3 more
doaj +2 more sources
ChemPhysMater, 2022 Temozolomide (TMZ) is a clinically approved drug for glioblastoma (GBM) therapy. However, as a result of methylguanine-DNA-methyltransferase (MGMT), which is able to repair damaged DNA-damage repairing, TMZ usually yields unsatisfactory therapeutic ...
Meng Zheng +10 more
doaj +1 more source
Photopolymerization-Induced Polymersome Rupture [PDF]
Langmuir, 2019 Poly(butadiene)- b-poly(ethylene oxide) (PBut2.5- b-PEO1.3) giant polymersomes were prepared using an emulsion-centrifugation method. The impact of a fast decrease of the osmotic pressure inside the lumen of giant PBut- b-PEO vesicles was studied by confocal microscopy. This osmotic imbalance was created by performing the photoinduced polymerization of
Sophie C. Larnaudie +4 more
openaire +2 more sources
From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates
Advanced Materials, EarlyView.Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot +3 more
wiley +1 more source
Science and Technology of Advanced Materials, 2015 Introduction of ligands into 100 nm scaled hollow capsules has great potential for diagnostic and therapeutic applications in drug delivery systems. Polyethylene glycol-conjugated (PEGylated) polyion complex vesicles (PICsomes) are promising hollow nano ...
Wataru Kawamura +14 more
doaj +1 more source
Advanced NanoBiomed Research, EarlyView.Bowl‐shaped Janus nanomotors with platinum, iron oxide, and polypyrrole integrate catalytic, magnetic, and electric propulsion for targeted drug delivery. They demonstrate controlled, directional motion under varying pH and hydrogen peroxide conditions, with optimal performance in neutral media.
Kimia Tavakoli Dehaghi +3 more
wiley +1 more source
Modular Approach to the Functionalization of Polymersomes [PDF]
Biomacromolecules, 2020 Functionalizing polymersomes remains a challenge due to the limitation in reaction conditions applicable to the chemistry on the surface, hindering their application for selective targeting. In order to overcome this limitation, functionalization can be introduced right before the self-assembly.
Sjoerd J. Rijpkema +5 more
openaire +3 more sources
Artificial Cell Catalysts for Biotransformation: Design Principles and Process Integration
Biotechnology and Bioengineering, EarlyView.ABSTRACT Artificial cell catalysts are emerging as programmable biocatalytic platforms for sustainable molecular conversion. By reconstituting enzymes and functional modules within synthetic compartments, they combine the selectivity of biological catalysis with the design flexibility of synthetic materials.
Iori Kobayashi +2 more
wiley +1 more source
Crystalline Poly(L‐Lactic Acid) Nanoparticles via Nonsolvent‐Induced Cascade Phase Separation
Journal of Polymer Science, EarlyView.Water is used as the nonsolvent to induce liquid/liquid phase separation (LLPS) of poly(L‐lactic acid) (PLLA)/propylene carbonate solution and PLLA crystallization. Due to the two levels of cascade LLPS coupled with confined PLLA crystallization, three types of polymeric nanoparticles, including PLLA single crystals, Ouzo crystalsomes, and sheaf‐like ...
Niloofar Esmati +3 more
wiley +1 more source
Small, EarlyView.Schematic representation of diffusion‐based versus pH‐triggered drug release within a bacterial biofilm. In diffusion‐based systems, drug cargo is gradually released independent of local pH, resulting in rapid burst release and reduced sustained concentrations.
Amalie Kjær Andresen +9 more
wiley +1 more source