Results 41 to 50 of about 3,624 (199)

Apoptosis induction and proliferation inhibition by silibinin encapsulated in nanoparticles in MIA PaCa-2 cancer cells and deregulation of some miRNAs [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Silibinin, as an herbal compound, has anti-cancer activity. Because of low solubility of silibinin in water and body fluids, it was encapsulated in polymersome nanoparticles and its effects were evaluated on pancreatic cancer cells and ...
Fatemeh Khakinezhad Tehrani, Najmeh Ranji, Fatemeh Kouhkan, Simzar Hosseinzadeh   +3 more
doaj   +1 more source

Durable vesicles for reconstitution of membrane proteins in biotechnology [PDF]

, 2017
The application of membrane proteins in biotechnology requires robust, durable reconstitution systems that enhance their stability and support their functionality in a range of working environments. Vesicular architectures are highly desirable to provide
Arinaminpathy, Armengol, Barrera, Battaglia, Bayburt, Bayley, Bieligmeyer, Biner, Booth, Cantor, Channon, Chemin, Chen, Chen, Cheng, Choi, Choi, Dao, De Vocht, Discher, Dürr, Einfalt, Frauenfeld, Früh, Gao, Go, Graff, Graff, Grit, Gutierrez, Habel, Hunte, Ichihashi, Israelachvili, Itel, Kamiya, Khan, Kim, Kita-Tokarczyk, Klara, Kowal, Kuang, Kumar, Kumar, Landau, Lars J.C. Jeuken, le Maire, Le Meins, Lee, Lim, Lomora, Lomora, LoPresti, Maglia, Marsden, Marsh, Marsh, Molinaro, Motta, Muhammad, Nallani, Nam, Nam, Palivan, Panneerselvam, Paul A. Beales, Pautot, Phale, Popot, Prabudiansyah, Rigaud, Sanobar Khan, Schirmer, Schulz, Schulz, Schwille, Seddon, Shen, Stephen P. Muench, Stoenescu, Tanner, Thoma, Walde, Winzen, Zaba   +84 more
core   +2 more sources

Generating biomembrane-like local curvature in polymersomes via dynamic polymer insertion

Nature Communications, 2021
Investigating biomembrane curvature formation is important for studying intracellular processes, but the instability of liposome models mimicking these membranes restricts exploration of membrane processes.
Jiawei Sun, Sjoerd J. Rijpkema, Jiabin Luan, Shaohua Zhang, Daniela A. Wilson   +4 more
doaj   +1 more source

Cascade Reactions in Multicompartmentalized Polymersomes [PDF]

Angewandte Chemie, 2013
AbstractEnzyme‐filled polystyrene‐b‐poly(3‐(isocyano‐L‐alanyl‐aminoethyl)thiophene) (PS‐b‐PIAT) nanoreactors are encapsulated together with free enzymes and substrates in a larger polybutadiene‐b‐poly(ethylene oxide) (PB‐b‐PEO) polymersome, forming a multicompartmentalized structure, which shows structural resemblance to the cell and its organelles. An
Peters, R.J.R.W., Marguet, M., Marais, S., Fraaije, M.W., van Hest, J.C.M., van Hest, J.C.M., Lecommandoux, S.   +6 more
openaire   +4 more sources

Bottom‐Up Coacervate‐Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life‐Like Systems

Angewandte Chemie, EarlyView.
Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo, Angshuman Das, Madelief A. M. Verwiel, Jan C. M. van Hest   +3 more
wiley   +2 more sources

Enzyme-responsive polymersomes ameliorate autophagic failure in a cellular model of GM1 gangliosidosis

Frontiers in Chemical Engineering, 2022
GM1 gangliosidosis is a lysosomal storage disorder caused by deficiency of β-galactosidase (βgal) and subsequent accumulation of GM1 ganglioside in lysosomes. One of the pathological aspects of GM1 gangliosidosis, and other storage disorders, is impaired
Bipin Chakravarthy Paruchuri, Sarah Smith, Jessica Larsen, Jessica Larsen   +3 more
doaj   +1 more source

Polymerization-Induced Polymersome Fusion [PDF]

Journal of the American Chemical Society, 2019
The dynamic interactions of membranes, particularly their fusion and fission, are critical for the transmission of chemical information between cells. Fusion is primarily driven by membrane tension built up through membrane deformation. For artificial polymersomes, fusion is commonly induced via the external application of a force field. Herein, fusion-
Spyridon Varlas, Robert Keogh, Yujie Xie, Sarah L. Horswell, Jeffrey C. Foster, Rachel K. O’Reilly   +5 more
openaire   +3 more sources

Bio‐Propelled Stomatocyte Nanomotors with Glutathione‐Responsiveness for Osteoarthritis Treatment

Angewandte Chemie, EarlyView.
Glutathione (GSH)‐responsive stomatocyte nanomotors with encapsulated MTX utilize oxygen to achieve autonomous motion and undergo GSH‐induced dissociation, enhancing cellular uptake, tissue penetration, and MTX release within the osteoarthritis (OA) region, thereby improving therapeutic efficacy.
Jianhong Wang, Mengsi Zhan, Hanglong Wu, Maarten Bransen, Ioanna Balmpouzi, Xianwen Lou, Junjie Liu, Nina Wang, Zhiqiang Wang, Heiner Friedrich, Jingxin Shao, Jan C. M. van Hest, Xiangyang Shi   +12 more
wiley   +2 more sources

Artificial Organelles with Orthogonal‐Responsive Membranes for Protocell Systems: Probing the Intrinsic and Sequential Docking and Diffusion of Cargo into Two Coexisting Avidin–Polymersomes

Advanced Science, 2021
The challenge of effective integration and use of artificial organelles with orthogonal‐responsive membranes and their communication in eukaryotic protocells is to understand the intrinsic membrane characteristics.
Xueyi Wang, Silvia Moreno, Susanne Boye, Peng Wang, Xiaoling Liu, Albena Lederer, Brigitte Voit, Dietmar Appelhans   +7 more
doaj   +1 more source

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Nanomaterials, 2022
Polymersomes are biomimetic cell membrane-like model structures that are self-assembled stepwise from amphiphilic copolymers. These polymeric (nano)carriers have gained the scientific community’s attention due to their biocompatibility, versatility, and ...
Elisa Hernández Becerra, Jennifer Quinchia, Cristina Castro, Jahir Orozco   +3 more
doaj   +1 more source