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Journal of the American Chemical Society, 2020
Hollow nanoparticles such as polymersomes have promising potentials in many fields. However, the design and construction of higher-order polymersomes with precisely controlled spatial compartments is still very challenging. Herein, we report a unique tetrapod polymersome that is assembled by the controlled fusion of four traditional spherical ...
Jiangang Xiao, Jianzhong Du
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Hollow nanoparticles such as polymersomes have promising potentials in many fields. However, the design and construction of higher-order polymersomes with precisely controlled spatial compartments is still very challenging. Herein, we report a unique tetrapod polymersome that is assembled by the controlled fusion of four traditional spherical ...
Jiangang Xiao, Jianzhong Du
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Annual Review of Biomedical Engineering, 2006
Polymersomes are self-assembled polymer shells composed of block copolymer amphiphiles. These synthetic amphiphiles have amphiphilicity similar to lipids, but they have much larger molecular weights, so for this reason—along with others reviewed here—comparisons of polymersomes with viral capsids composed of large polypeptide chains are highly ...
Discher, Dennis E, Ahmed, Fariyal
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Polymersomes are self-assembled polymer shells composed of block copolymer amphiphiles. These synthetic amphiphiles have amphiphilicity similar to lipids, but they have much larger molecular weights, so for this reason—along with others reviewed here—comparisons of polymersomes with viral capsids composed of large polypeptide chains are highly ...
Discher, Dennis E, Ahmed, Fariyal
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Polymersomes in Polymersomes: Multiple Loading and Permeability Control
Angewandte Chemie International Edition, 2011With such a compartmentalized structure, a mol-ecule encapsulated in the inner liposome, would have topermeate through two successive membranes, instead of asingle one before leaking into the outside environment. Thisdouble-membrane effect was demonstrated by observing theserumhalf-lifeofciprofloxacindrugincreasingfrom10 mininsingle liposomes to 6 h in
Maïté, Marguet +2 more
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Detergent-Aided Polymersome Preparation
Biomacromolecules, 2010Until now, most preparative methods used to form polymeric vesicles involve either organic cosolvents or sonication. In this communication, we demonstrate for the first time a detergent-aided method to produce polymersomes. Peptidic polymersomes were formed from the rod-rod block copolymer PBLG(36)-E, where PBLG is hydrophobic poly(gamma-benzyl l ...
Marsden H. R. +5 more
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Nachrichten aus der Chemie, 2012
AbstractPolymersome sind artifizielle Strukturen, die das Bauprinzip der Liposomen nutzen. Sie eignen sich unter anderem als Wirkstofftransporter und als Nanoreaktoren für Biomedizin und Biotechnik.
Jens Gaitzsch +2 more
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AbstractPolymersome sind artifizielle Strukturen, die das Bauprinzip der Liposomen nutzen. Sie eignen sich unter anderem als Wirkstofftransporter und als Nanoreaktoren für Biomedizin und Biotechnik.
Jens Gaitzsch +2 more
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Can Polymersomes Form Colloidosomes?
Journal of the American Chemical Society, 2012Hydroxy-functionalized polymersomes (or block copolymer vesicles) were prepared via a facile one-pot RAFT aqueous dispersion polymerization protocol and evaluated as Pickering emulsifiers for the stabilization of emulsions of n-dodecane emulsion droplets in water.
Thompson, Kate L. +3 more
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Renoprotective Angiographic Polymersomes
Advanced Functional Materials, 2020AbstractComputed tomography (CT) angiography is powerful for the diagnosis of vascular diseases. Unfortunately, this method usually requires a high dosage of iodinated contrast agents, which can lead to severe elevation of reactive oxygen species (ROS) levels within kidneys.
Danqing Liu +2 more
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Polymersome-Embedded Nanoparticles
Macromolecular Symposia, 2007AbstractSummary: Polymersomes are self assembled vesicles composed of fully synthetic amphiphilic diblock copolymers. Many of their properties are similar to lipid vesicles, although with often higher thermal and mechanical stability within their curved membrane. Incorporation of nanosized objects into their hydrophilic interior or hydrophobic membrane
Robert Sachsenhofer +3 more
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Multicompartment Polymersomes from Double Emulsions
Angewandte Chemie International Edition, 2011Versatile chambers: A microfluidic technique is used to generate polymersomes with multiple compartments using double emulsions with different morphology as templates (see scheme). The polymersomes could be utilized for encapsulation of multiple substances and as reaction vessels that enable triggered reaction with controlled stoichometry of the ...
Kim, SH, Shum, HC, Weitz, DA, Zhao, YJ
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