Results 201 to 210 of about 202,025 (268)

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

Direct microhaplotype genotyping for GT-seq (Genotyping-in-Thousands by Sequencing) using a diploid abundance model. [PDF]

PLoS Comput Biol
Campbell NR, Campbell AR, Blair SK, Finger AJ.   +3 more
europepmc   +1 more source

XChrom: A Cross‐Cell Chromatin Accessibility Prediction Model Integrating Genomic Sequence and Cellular Context

Advanced Science, EarlyView.
XChrom is a deep learning framework that integrates genomic sequence and single‐cell context to predict chromatin accessibility. It generalizes to unseen cells and genomic regions, enabling cross‐sample and cross‐species analysis. Applied to COVID‐19 patient data, XChrom reveals key transcriptional regulatory mechanisms and disease‐associated ...
Yuanyuan Miao, Xuan Liang, Wenwen Zhang, Dongmei Han, Yurun Li, Zhen Wang   +5 more
wiley   +1 more source

Pleiotropic Phenotype of RYR2 Exon 3 Deletion: Biventricular Noncompaction and Malignant Arrhythmias. [PDF]

JACC Case Rep
Faucher L, Cardi T, Fitouchi S, Baldacini C, Koenig B, Schatz A, Kanso M, Morel O, Marzak H, Jesel L.   +9 more
europepmc   +1 more source

Molecular Characterization of Lumpy Skin Disease Virus in Bulgaria: Phylogenetic Insights Based on the RPO30 Gene. [PDF]

Vet Sci
Goujgoulova G, Koev K, Stoimenov G.
europepmc   +1 more source

Prevalence and Molecular Epidemiology of Nontyphoidal Salmonella enterica Serovars Enteritidis and Typhimurium in Bushmeat Carcasses Sold in the Centre Region Markets, Cameroon. [PDF]

Microbiologyopen
Dongmo M, Mbuh Nji A, Nsen Bughe R, Fomboh Tah C, Fon Mbacham W, Sado Kamdem SL.   +5 more
europepmc   +1 more source

Intraspecific sequence variation and complete genomes refine the identification of rapidly evolved regions in humans. [PDF]

Cell Genom
Luo Y, Mangan RJ, Weaver S, Zhao SA, Mosti F, Thomas MC, Karra R, Silver DL, Kellis M, Lowe CB.   +9 more
europepmc   +1 more source

Information-Entropy-Based Single Amino Acid Polymorphism Analysis Reveals Functional Variance of Enterovirus 2A Proteases. [PDF]

Microorganisms
Zhu X, Guo Z, Wang Q, Ge XY, Xiao Y, Qiu Y.   +5 more
europepmc   +1 more source