Results 21 to 30 of about 648,932 (289)

Genetic Polymorphisms in Pharmaceuticals and Chemotherapy

World Journal of Oncology, 2021
The study of genetic polymorphisms has significantly advanced the field of personalized medicine. Polymorphism of genes influence the efficacy of drugs used for treating medical conditions such as depression, cardiac diseases, thromboembolic disorders, oncological diseases, etc. The study of genetic polymorphism is beneficial for drug safety as well as
Achuta Kumar Guddati, Aneesha Choudary Gummadi   +1 more
openaire   +3 more sources

Identificación de tres nuevas mutaciones en el gen RB1 en pacientes con retinoblastoma esporádico en Colombia

Biomédica: revista del Instituto Nacional de Salud, 2013
Introducción. El retinoblastoma es un cáncer pediátrico de la retina originado por la expresión alterada o ausente de la proteína del retinoblastoma (pRb).
Martha Lucía Serrano, Juan José Yunis
doaj   +1 more source

Forensic Application of ForenSeqTM DNA Signature Prep Kit in Zhengjiang She Ethnic Group

Fayixue Zazhi, 2021
ObjectiveTo evaluate the ability of the ForenSeqTM DNA Signature Prep kit （ForenSeq kit） in analyzing the sequence information of STRs in Zhejiang She ethnic group and its forensic application efficacy.MethodsA total of 50 Zhejiang She ethnic group ...
QU Yi-ling, LIN Yuan, YANG Zi-hao, TAO Rui-yang, XIA Ruo-cheng, CAO Zheng-jun, GAO Rui-xiang, YU Huan, WANG Zi-wei, YANG Qi, ZHANG Xiao-chun, ZHANG Su-hua, LI Cheng-tao   +12 more
doaj   +1 more source

Gravidade da lesão angiográfica coronariana e polimorfismo da APOE nas síndromes coronarianas agudas Severidad de la lesión angiográfica coronaria y polimorfismo de la APOE en los síndromes coronarios agudos Severity of angiographic coronary obstruction and the apolipoprotein E polymorphism in acute coronary syndromes

Arquivos Brasileiros de Cardiologia, 2009
FUNDAMENTO: Existem evidências de associação entre o polimorfismo da apolipoproteína E (APOE) e a doença coronariana, entretanto há controvérsias. OBJETIVO: Avaliar a associação entre o número de vasos coronarianos acometidos por obstrução significativa ...
Arlisa Monteiro de Castro Dias, Amália Faria dos Reis, Claudia Guerra Murad Saud, Maria das Graças Leitão Chilinque, Rafaela Ferreira Leite, Rosemery Nunes Cardoso Abdalah, Mariana Ferreira Fiqueiredo, Georgina Severo Ribeiro, Carlos Augusto Cardozo de Faria   +8 more
doaj   +1 more source

A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function. [PDF]

, 2019
The intra-renal dopamine (DA) system is highly expressed in the proximal tubule and contributes to Na+ and blood pressure homeostasis, as well as to the development of nephropathy.
Baker, Dewleen G, Biswas, Nilima, González-Sarmiento, Rogelio, Hightower, C Makena, Ichinose, Hiroshi, Kurosaki, Hiroki, León-Jiménez, David, Lipkowitz, Michael S, Mahata, Manjula, Miramontes-Gonzalez, Jose Pablo, Nievergelt, Caroline M, O'Connor, Daniel T, Schork, Andrew J, Vaingankar, Sucheta, Zhang, Kuixing, Ziegler, Michael G   +15 more
core   +2 more sources

Homocisteína e polimorfismos dos genes MTHFR e VEGF: impacto na doença arterial coronariana Homocisteína y polimorfismos de los genes MTHFR y VEGF: impacto en la enfermedad arterial coronaria Homocysteine and MTHFR and VEGF gene polymorphisms: impact on coronary artery disease

Arquivos Brasileiros de Cardiologia, 2009
FUNDAMENTO: Polimorfismos em genes relacionados ao desenvolvimento da aterosclerose, angiogênese e metabolismo da homocisteína (Hcy) podem ser fatores de risco para a doença arterial coronariana (DAC).
Alexandre Rodrigues Guerzoni, Patrícia Matos Biselli, Moacir Fernandes de Godoy, Doroteia Rossi Silva Souza, Renato Haddad, Marcos Nogueira Eberlin, Erika Cristina Pavarino-Bertelli, Eny Maria Goloni-Bertollo   +7 more
doaj   +1 more source

Factores genéticos y ambientales asociados con la respuesta a warfarina en pacientes colombianos

Biomédica: revista del Instituto Nacional de Salud, 2010
Introducción. La warfarina es un anticoagulante de difícil manejo por su estrecho margen terapéutico y los numerosos factores que influyen en la respuesta. Objetivo.
Carlos Isaza, Leonardo Beltrán, Julieta Henao, Gloria Porras, Alfredo Pinzón, Álvaro Vallejos, Jorge Machado   +6 more
doaj   +1 more source

Genetic polymorphisms in sepsis

Pediatric Critical Care Medicine, 2005
Wide variability exists in the susceptibility to and outcome from sepsis even within similar intensive care unit populations. Some of this variability in the host may be due to genetic variation in genes coding for components of the innate immune response.To review the evidence for a genetic influence on the susceptibility to and outcome from sepsis ...
Michael W. Quasney, Adrienne G. Randolph, Mary K. Dahmer, Sally H. Vitali   +3 more
openaire   +4 more sources

Significant correlation of angiotensin converting enzyme and glycoprotein IIIa genes polymorphisms with unexplained recurrent pregnancy loss in north of Iran [PDF]

, 2016
Background: Spontaneous abortion is considered as the most complex problem during pregnancy. Thrombophilia is resumed as a cause of recurrent pregnancy loss (RPL). Glycoprotein IIIa (GPIIIa) gene is involved in thrombosis and abortion.
Farazmandfar, T., Fazelnia, S., Hashemi-Soteh, S.M.B.   +2 more
core   +1 more source

Genetic polymorphisms and folate status [PDF]

Congenital Anomalies, 2017
AbstractModerate hyperhomocysteinemia‐induced low folate status is an independent risk factor for cardiovascular disease, dementia, and depression. Folate is an essential cofactor in the one‐carbon metabolism pathway and is necessary in amino acid metabolism, purine and thymidylate synthesis, and DNA methylation.
Mami Hiraoka, Yasuo Kagawa
openaire   +3 more sources