Results 21 to 30 of about 616,417 (331)

The rs2304256 Polymorphism in Gene Is Associated with Protection for Type 1 Diabetes Mellitus [PDF]

Diabetes & Metabolism Journal, 2021
Background Tyrosine kinase 2 (TYK2) is a candidate gene for type 1 diabetes mellitus (T1DM) since it plays an important role in regulating apoptotic and pro-inflammatory pathways in pancreatic β-cells through modulation of the type I interferon signaling
Felipe Mateus Pellenz, Cristine Dieter, Guilherme Coutinho Kullmann Duarte, Luís Henrique Canani, Bianca Marmontel de Souza, Daisy Crispim   +5 more
doaj   +1 more source

Migraine and Genetic Polymorphisms: An Overview [PDF]

The Open Neurology Journal, 2012
The relationship between genetic polymorphisms and migraine as a cause of an increased risk of thrombotic disorders development is still debated In this respect, factor V Leiden, factor V (H1299R), prothrombin G20210A, factor XIII (V34L), β-fibrinogen, MTHFR (C677T), MTHFR (A1298C), APO E, PAI-1, HPA-1 and ACE I/D seem to play a determinant role in ...
V. Pizza, A. Agresta, A. Agresta, E. Lamaida, N. Lamaida, F. Infante, CAPASSO, Anna   +6 more
openaire   +4 more sources

Genetic Polymorphisms in Pharmaceuticals and Chemotherapy

World Journal of Oncology, 2021
The study of genetic polymorphisms has significantly advanced the field of personalized medicine. Polymorphism of genes influence the efficacy of drugs used for treating medical conditions such as depression, cardiac diseases, thromboembolic disorders, oncological diseases, etc. The study of genetic polymorphism is beneficial for drug safety as well as
Achuta Kumar Guddati, Aneesha Choudary Gummadi   +1 more
openaire   +3 more sources

Infectivity and Genetic Polymorphism of Anopheles Maculatus and An. Vagus in Diverse Endemicity Malaria Areas in The Kokap Sub-District of Kulon Progo [PDF]

, 2016
BACKGROUND: It is crucial to regularly monitor the infectivity and genetic polymorphism of Anopheles sp in endemic areas for early detection and accurate rapid response planning of indigenous malaria transmission.
Andiyatu, A. (Andiyatu), Handayani, N. (Niken), Moeljopawiro, S. (Sukarti), Soesilohadi, H. (Hidayat)   +3 more
core   +1 more source

Niveles de homocisteína y polimorfismos de los genes de la MTHFR y la CBS en pacientes colombianos con trombosis venosa superficial y profunda

Biomédica: revista del Instituto Nacional de Salud, 2010
Introducción. Se produce trombosis cuando en el sistema hemostático se desequilibran los mecanismos procoagulantes, anticoagulantes y fibrinolíticos, y se forman coágulos dentro de los vasos sanguíneos.
Claudia Ayala, Reggie García, Edith Cruz, Karol Prieto, Marta Bermúdez   +4 more
doaj   +1 more source

The relationship between tacrolimus concentration-dose ratio and genetic polymorphism in patients subjected to renal transplantation [PDF]

Vojnosanitetski Pregled, 2018
Background/Aim. Tacrolimus concentration-dose ratio as a potential therapeutic drug monitoring strategy was suggested to be used for the patients subjected to renal transplantation.
Rančić Nemanja, Vavić Neven, Cikota-Aleksić Bojana, Magić Zvonko, Mikov Momir, Bokonjić Dubravko, Šegrt Zoran, Dragojević-Simić Viktorija   +7 more
doaj   +1 more source

Genetic Polymorphisms in COL1A2 gene and the Risk of Tendinopathy: Case-Control Study [PDF]

Revista Brasileira de Ortopedia, 2023
Objective To evaluate the influence of polymorphisms on genes encoding type I collagen and the genetic susceptibility of tendinopathy. Methodology Case-control study involving 242 Brazilian athletes from different sports modalities (55 cases of ...
Lucas Rafael Lopes, João Antônio Matheus Guimarães, Marcus Vinicius Galvão Amaral, Camili Gomes Pereira, Victor Soares Wainchtock, Rodrigo Araujo Goes, Vitor Almeida Ribeiro de Miranda, Jamila Alessandra Perini   +7 more
doaj   +1 more source

Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair [PDF]

, 2002
The DNA single-strand break repair (SSBR) protein XRCC1 is required for genetic stability and for embryonic viability. XRCC1 possesses two BRCA1 carboxyl-terminal (BRCT) protein interaction domains, denoted BRCT I and II.
Caldecott, Keith W, Taylor, Richard M, Thistlethwaite, Angela   +2 more
core   +3 more sources

Evidencia de asociación entre el gen SLC6A4 y efectos epistáticos con variantes en HTR2A en la etiología del autismo en la población antioqueña

Biomédica: revista del Instituto Nacional de Salud, 2012
Introducción. El espectro autista constituye un grupo de trastornos graves del neurodesarrollo, conun fuerte componente genético. Se ha sugerido un papel importante del sistema serotoninérgico en el desarrollo de este grupo de trastornos, con base en los
Ana Victoria Valencia, Ana Lucía Páez, María Elena Sampedro, Clara Ávila, Julio Cesar Cardona, Catalina Mesa, Lina Galvis, Jaime Carrizosa, Mauricio Camargo, Andrés Ruíz, William Cornejo, Gabriel Bedoya   +11 more
doaj   +1 more source

Polymorphism in rapidly-changing cyclic environment [PDF]

Physical Review E 100, 032401 (2019), 2019
Selection in a time-periodic environment is modeled via the continuous-time two-player replicator dynamics, which for symmetric pay-offs reduces to the Fisher equation of mathematical genetics. For a sufficiently rapid and cyclic [fine-grained] environment, the time-averaged population frequencies are shown to obey a replicator dynamics with a non ...
arxiv   +1 more source