Results 71 to 80 of about 3,200,406 (285)

'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?

International Journal of Epidemiology, 2003
Associations between modifiable exposures and disease seen in observational epidemiology are sometimes confounded and thus misleading, despite our best efforts to improve the design and analysis of studies.
G. Smith, S. Ebrahim
semanticscholar   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Cholesterol Ester Transfer Protein Taq1B Polymorphism and Its Association with Cardiovascular Risk Factors in Patients Undergoing Angiography in Yazd, Eastern Iran: A Cross-Sectional Study [PDF]

Iranian Journal of Medical Sciences
Background: Several studies assessed the relationship between the cholesterol ester transfer protein (CETP) Taq1B gene polymorphism (rs708272) with risk factors of cardiovascular diseases (CVDs). However, their findings were inconsistent.
Azam Ahmadi-Vasmehjani, Seyed Mostafa SeyedHosseini, Sayyed Saeid Khayyatzadeh, Farzan Madadizadeh, Mahta Mazaheri-Naeini, Mahdie Yavari, Zahra Darabi, Sara Beigrezaei, Marzieh Taftian, Vahid Arabi, Maryam Motallaei, Amin Salehi-Abargouei, Azadeh Nadjarzadeh   +12 more
doaj   +1 more source

Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array

Plant Biotechnology Journal, 2014
High-density single nucleotide polymorphism (SNP) genotyping arrays are a powerful tool for studying genomic patterns of diversity, inferring ancestral relationships between individuals in populations and studying marker–trait associations in mapping ...
Shichen Wang, Debbie Wong, K. Forrest, A. Allen, S. Chao, B. Huang, M. Maccaferri, S. Salvi, S. Milner, L. Cattivelli, A. Mastrangelo, A. Whan, S. Stephen, G. Barker, Ralf Wieseke, J. Plieske, International Wheat Genome Sequencing Consortium, M. Lillemo, D. Mather, R. Appels, R. Dolferus, G. Brown-Guedira, A. Korol, Alina Akhunova, C. Feuillet, J. Salse, M. Morgante, C. Pozniak, M. Luo, J. Dvorak, M. Morell, J. Dubcovsky, M. Ganal, R. Tuberosa, C. Lawley, Ivan Mikoulitch, C. Cavanagh, K. Edwards, M. Hayden, E. Akhunov   +39 more
semanticscholar   +1 more source

Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins

FEBS Open Bio, EarlyView.
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet, Julia Bartoli, Atakan Kabtan, Chloé M. Piras, Audrey C. Tempier, Eric Cascales, Julie P. Viala   +6 more
wiley   +1 more source

Polymorphism of peripheral blood T cell receptor β chain variable region in patients with clinically isolated syndrome

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Objective To investigate the polymorphism of T cell receptor β chain variable region (TCRVβ) in peripheral blood of clinically isoiated syndrome (CIS) patients. To preliminarily predict the specific TCRVβ fragment of CIS and its diagnostic value for CIS.
Yan WU, Ji⁃hong ZHANG, Hui⁃qing DONG, Da⁃wei LI, Zheng LIU, Sui⁃gui WAN   +5 more
doaj  

Genes as Cues of Relatedness and Social Evolution in Heterogeneous Environments. [PDF]

PLoS Computational Biology, 2016
There are many situations where relatives interact while at the same time there is genetic polymorphism in traits influencing survival and reproduction. Examples include cheater-cooperator polymorphism and polymorphic microbial pathogens.
Olof Leimar, Sasha R X Dall, Peter Hammerstein, John M McNamara   +3 more
doaj   +1 more source

Polimorfismos do gene da interleucina-13 nas posições -1055 C/T e +2044 G/A em pacientes com carcinoma espinocelular de cabeça e pescoço Interleukin-13 gene polymorphisms at -1055 C/T and +2044 G/A positions in patients with squamous cell carcinoma of head and neck

Brazilian Journal of Otorhinolaryngology, 2012
O carcinoma espinocelular (CEC) é a neoplasia mais comum do trato aerodigestivo superior. A interleucina-13 (IL-13) é uma citocina imunorreguladora com polimorfismos relatados para seu gene associados com a mesma doença, especialmente asma e alergia.
Bijan Khademi, Seyed Basir Hashemi, Abbass Ghaderi, Ali Shahrestani, Mohammad Mohammadianpanah   +4 more
doaj   +1 more source

The Drosophila melanogaster Genetic Reference Panel

Nature, 2012
A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness.
T. Mackay, S. Richards, Eric A. Stone, A. Barbadilla, J. Ayroles, Dianhui Zhu, Sònia Casillas, Yi Han, M. Magwire, J. Cridland, M. Richardson, R. Anholt, Maite G. Barrón, Crystal Bess, K. Blankenburg, M. A. Carbone, David Castellano, Lesley S. Chaboub, Laura H. Duncan, Zeke Harris, Mehwish Javaid, J. Jayaseelan, S. Jhangiani, K. Jordan, F. Lara, Faye Lawrence, Sandy Lee, P. Librado, Raquel Linheiro, R. F. Lyman, A. Mackey, Mala Munidasa, D. Muzny, L. Nazareth, I. Newsham, Lora Perales, ling-ling Pu, Carson Qu, Miquel Ràmia, J. Reid, S. Rollmann, J. Rozas, Nehad I. Saada, Lavanya Turlapati, K. Worley, Yuanqing Wu, A. Yamamoto, Yiming Zhu, C. Bergman, Kevin R. Thornton, D. Mittelman, R. Gibbs   +51 more
semanticscholar   +1 more source

Stability of Underdominant Genetic Polymorphisms in Population Networks [PDF]

arXiv, 2015
Heterozygote disadvantage is potentially a potent driver of population genetic divergence. Also referred to as underdominance, this phenomena describes a situation where a genetic heterozygote has a lower overall fitness than either homozygote. Attention so far has mostly been given to underdominance within a single population and the maintenance of ...
arxiv