Results 201 to 210 of about 144,897 (315)

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

Genetic polymorphism of CCR5 (59029A/G) and CCR2 (-64I A/G) promoters in HIV infected patients. [PDF]

Pak J Med Sci
Khalid A, Tahir R, Jahan S, Javed H.
europepmc   +1 more source

Development and analytical validation of a targeted short‐read next generation sequencing‐based pharmacogenetic panel for comprehensive variant detection

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen, Nils Johan Fredriksson, Michael Andresen, Jon Jonasson, Malin Lindqvist Appell, Henrik Gréen   +5 more
wiley   +1 more source

Evaluation of ERCC4 (XPF) gene rs6498486 polymorphism and its potential role in breast cancer risk among Bangladeshi women. [PDF]

BMC Cancer
Hossain I, Ivy SC, Islam MS, Shahriar M.
europepmc   +1 more source

Assessing differences among elasmobranch nurseries to aid conservation based on a genomics framework

Conservation Biology, EarlyView.
Abstract Elasmobranch nurseries often differ in environmental conditions, demographics, and use patterns. These differences affect the distribution of genetic variation among nurseries. However, conservation and management strategies often fail to account for such differences because they are difficult to characterize.
Dominic G. Swift, Amanda M. Barker, William B. Driggers III, Bryan S. Frazier, Douglas H. Adams, James J. Gelsleichter, Dana M. Bethea, Bethany M. Deacy, David S. Portnoy   +8 more
wiley   +1 more source

Association of the Endothelial Nitric Oxide Synthase (eNOS) G894T Gene Polymorphism With Type 2 Diabetes Mellitus in a Tunisian Population. [PDF]

Endocrinol Diabetes Metab
Ba A, Ayoub M, Aboulkacem S, Belhedi M, Aouni Z, Mazigh C.   +5 more
europepmc   +1 more source

The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, EarlyView.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source

Exploratory Analysis of TLR2, TLR4, Interleukin 6 and Interleukin 10 Gene Polymorphisms in Relation to Clinical Early-Onset Sepsis in Preterm Neonates: A Single-Center Study. [PDF]

Life (Basel)
Baizat M, Iancu M, Zaharie G, Hășmășanu M, Matyas M, Rotar IC, Lucaciu RL, Hangan AC, Gog Bogdan S, Procopciuc LM.   +9 more
europepmc   +1 more source

Worldwide Invasions of Centrarchidae: The Dark Side of the Sunfish Family

Fish and Fisheries, EarlyView.
ABSTRACT Freshwater fish invasions are major drivers of global ecological change, disrupting native biodiversity and ecosystem functions. However, many invasive fish hold significant socioeconomic value, resulting in conflict over their management. Centrarchidae, which are globally distributed and are important for sportfishing and aquaculture, are now
Neil Angelo Abreo, Jonathan Tibo, António Barbosa Nogueira, Athanasios Nikolaou, Cüneyt Kaya, Ali Serhan Tarkan, Irmak Kurtul, Stelios Katsanevakis, Ronaldo Sousa, Teun Everts, Emili García‐Berthou, John S. Hargrove, Ana Clara Sampaio Franco, Jelger Erik Herder, Julian D. Olden, Darragh J. Woodford, Antonín Kouba, J. Rob Britton, Ismael Soto, Phillip J. Haubrock   +19 more
wiley   +1 more source

Identification of an in-frame insertion in ACKR1 in five individuals from Agri community, India. [PDF]

Hematol Transfus Cell Ther
Roshan S, Prakash S, Kanjaksha G, Ajit G.   +3 more
europepmc   +1 more source