Results 121 to 130 of about 444,739 (309)

SCRIPT: Predicting Single‐Cell Long‐Range Cis‐Regulation Based on Pretrained Graph Attention Networks

open access: yesAdvanced Science, EarlyView.
SCRIPT is a novel method inferring single‐cell cis‐regulatory relationships (CRRs) from transcriptomic and chromatin accessibility data. SCRIPT incorporates two key innovations: graph causal attention networks supported by empirical CRR evidence, and representation learning enhanced through pretraining on atlas‐scale single‐cell data.
Yu Zhang   +13 more
wiley   +1 more source

Close association between A118G single nucleotide polymorphism and opioid, alcohol, and nicotine dependence

open access: yesPsychology Research and Behavior Management, 2012
Shailendra KapoorRichmond, VA, USAI read with great interest the article by Cosci et al in a recent issue of your journal.1 The article provides for highly interesting reading and is very thought-provoking. Interestingly, the past few years have seen the
Kapoor S
doaj  

DNA Polymorphisms in River Buffalo Leptin Gene

open access: yesItalian Journal of Animal Science, 2010
Leptin is a protein involved in the regulation of feed intake, fat metabolism, whole body energy balance, reproduction and hematopoiesis. In cattle Leptin gene has been considered a potential QTL influencing several production traits like meat production,
B. Moioli   +7 more
doaj   +1 more source

Co‐Selection of Low Cadmium Accumulation and High Yield During Tomato Improvement

open access: yesAdvanced Science, EarlyView.
This study finds that large‐fruited tomatoes accumulate less cadmium (Cd) compared to wild tomatoes and cherry tomatoes. This is because, during the improvement process of tomato, the low‐Cd allele LCT1A and the large fruit allele fw3.2T are closely linked, leading to a co‐selection event.
Xingyu Zhang   +11 more
wiley   +1 more source

Manipulating Unisexual–Sexual Reproduction Transition to Engineer Genome‐Reconstructed Polyploids

open access: yesAdvanced Science, EarlyView.
This study developed an efficient approach to generate genome‐reconstructed polyploids involving unisexual gynogenetic Carassius gibelio, sexual C. auratus, and sexual C. cuvieri. The selected superior clone inherited gynogenesis ability of C. gibelio and herpesvirus resistance of wild C.
Meng Lu   +9 more
wiley   +1 more source

Allelic Frequency of Kappa-Casein Locus (Asp148/Ala) in F1: Simmental (Bos Taurus) X Ongole Grade (Bos Indicus) [PDF]

open access: yes, 2012
This study was conducted to detect the genetic variants (single nucleotide polymorphism) of kappa-casein locus (Asp148/Ala) in F1: Simmental (Bos taurus) x Ongole grade (Bos indicus), SIMPO.
Mu\u27in, M. A. (M)   +1 more
core   +1 more source

Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression

open access: yesAdvanced Science, EarlyView.
Genome‐wide analyses indicate that reduced ventral diencephalon and thalamus volumes, along with decreased functional connectivity within the triple network (DMN/CEN/SN), are uniquely associated with the risk of major depression (MD) onset, compared to other similar severe psychiatric disorders.
Ming‐Min Xu   +7 more
wiley   +1 more source

Determination of single-nucleotide polymorphism in the proximal promoter region of apolipoprotein M gene in coronary artery diseases

open access: yesInternational Journal of General Medicine, 2009
Lu Zheng1, Guanghua Luo1, Xiaoying Zhang1, Jun Zhang1, Jiang Zhu1, Jiang Wei1, Qinfeng Mu1, Lujun Chen1, Peter Nilsson-Ehle2, Ning Xu21Comprehensive Laboratory, The Third Affiliated Hospital, Suzhou University, Changzhou China; 2Division of Clinical ...
Lu Zheng   +3 more
doaj  

Peptide Hormone‐Mediated Regulation of Plant Development and Environmental Adaptability

open access: yesAdvanced Science, EarlyView.
In this review, recent advances in understanding the roles of plant peptide hormones in regulating growth, reproduction, and environmental adaptability are systematically summarized. It further elucidates the challenges in studying these peptides, such as their low abundance, functional redundancy, and complex signaling mechanisms, and highlights their
Xin Li   +8 more
wiley   +1 more source

One‐Pot Isothermal Nucleic Acid Amplification Assisted CRISPR/Cas Detection Technology: Challenges, Strategies, and Perspectives

open access: yesAdvanced Science, EarlyView.
This review combines the current status of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)‐based molecular diagnostic technology to expound the necessity and challenges faced in promoting the development of one‐pot detection. Besides, the focus is on a comprehensive summary and incisive analysis of emerging strategies for one‐pot ...
Hongyan Liu   +10 more
wiley   +1 more source

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