Results 121 to 130 of about 260,303 (252)
British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
APOE genotype and the effect of statins on lipid outcomes: A meta‐analysis
British Journal of Clinical Pharmacology, EarlyView.Aim APOE genotype may affect statin therapy response. We conducted a meta‐analysis to update and quantify this association across various outcomes. Methods We searched seven databases (MEDLINE, Scopus, Web of Science, the Cochrane Library, APA PsycINFO, CINAHL Plus and ClinicalTrials.gov) on 9 May 2024.
Innocent G. Asiimwe +4 more
wiley +1 more source
Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases
BMEMat, EarlyView.This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou +6 more
wiley +1 more source
Early evolutionary history of the seed
Biological Reviews, EarlyView.ABSTRACT The seed is an essential stage in the life history of gymnospermous and angiospermous plants, facilitating both their survival and dispersal. We reappraise knowledge of the evolutionary history of the gymnospermous seed, from its origin in the late Devonian through to the well‐known end‐Permian extinctions – an interval encompassing the ...
Richard M. Bateman +2 more
wiley +1 more source
The power of many: when genetics met yeasts and high‐throughput
Biological Reviews, EarlyView.ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley +1 more source
Direct single-nucleotide polymorphism genotyping from whole blood without DNA extraction. [PDF]
J Equine SciFurukawa R +6 more
europepmc +1 more source
Individualised niches: an integrative conceptual framework across behaviour, ecology, and evolution
Biological Reviews, EarlyView.ABSTRACT Individuals differ. While seemingly trivial, this insight has nevertheless led to paradigm shifts, as three key fields of organismal biology have seen marked changes in key concepts over the past few decades. In animal behaviour, it has become increasingly recognised that behavioural differences among individuals can be stable over time and ...
Oliver Krüger +27 more
wiley +1 more source
Aldehyde reductase as potential measurement for retinitis pigmentosa: A two-sample Mendelian randomization (MR) study. [PDF]
Medicine (Baltimore)Yan W, Long P, Chen C, Zhang X, Chen T.
europepmc +1 more source
Evaluation of gene editing in CHO cells using the Cas‐CLOVER system
Biotechnology Progress, EarlyView.Abstract Recent advances in gene editing technologies have transformed the genetic engineering of Chinese hamster ovary (CHO) hosts, enabling the development of cell lines with improved stability and productivity. In this study, we employed the programmable nuclease (PN) Cas‐CLOVER to precisely target the Glutamine synthetase (GS) locus in CHO cells. A
Tiffany McLamarrah +13 more
wiley +1 more source
Correction: Genetic diversity and population structure analyses of tropical maize inbred lines using Single Nucleotide Polymorphism markers. [PDF]
PLoS OneGunundu R, Shimelis H, Tesfamariam SA.
europepmc +1 more source