Results 191 to 200 of about 454,115 (308)

Plasma metabolites mediate the causal relationship between gut microbiota and erectile dysfunction: insights from Mendelian randomization study. [PDF]

Sex Med
Wang W, Tang B, Yuan S, Luan H, Qi T, Chen J.   +5 more
europepmc   +1 more source

Targeting Cryptochromes in Chronic Diseases

Cell Biology International, EarlyView.
ABSTRACT The circadian clock generates 24‐h molecular rhythms through transcription–translation negative feedback loops (TTFLs) and regulates daily physiological processes such as sleep–wake cycles, body temperature, hormone secretion, metabolism, and immune function.
Takuro Toda, Tsuyoshi Hirota
wiley   +1 more source

Correlation between Neurotransmitter Transporter Gene Variants and Childhood Autism Spectrum Disorder: A Case-control Study. [PDF]

Saudi J Med Med Sci
Shen C, Shen L, Qu F, He C, Yu H, Zhang Z, Liu J.   +6 more
europepmc   +1 more source

HLA-J, A SECOND INACTIVATED CLASS I HLA GENE RELATED TO HLA-G AND HLA-A [PDF]

, 1992
Girdlestone, J., Messer, Gerald, Orr, Harry T., Parham, P., Weiss, Elisabeth H., Zemmour, Jaqueline   +5 more
core   +1 more source

Gankyrin‐Protein Interactions in GI Cancers: A Novel Target of New Therapeutics

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Gankyrin (PSMD10) is a 25 kDa oncogenic protein and regulatory subunit of the 26S proteasome, characterized by a sevenfold ankyrin repeat domain. Gankyrin is overexpressed in various malignancies, particularly gastrointestinal (GI) cancers. Gankyrin contributes to tumorigenesis by modulating key signaling pathways and engaging in oncogenic ...
Shuang Li, Yuky Lam, Aaron Muth, Zhe‐Sheng Chen, Shanzhi Wang   +4 more
wiley   +1 more source

Tracing metastatic spread in pediatric solid tumors using copy number and targeted deep sequencing. [PDF]

J Pathol
Andersson N, Ferro M, Jansson C, Chattopadhyay S, Karlsson J, Gisselsson D.   +5 more
europepmc   +1 more source

Deuteration of Six‐Membered N‐Heteroarenes: Chemistry and Applications

Chemistry – A European Journal, EarlyView.
Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Liju Raju, Davide Benedetto Tiz, Adrian Iles, Janez Košmrlj, Ross D. Jansen‐van Vuuren   +4 more
wiley   +1 more source

First reported <i>TRIB1</i> copy number loss in myelodysplastic syndrome (MDS) revealed by single nucleotide polymorphism array (SNP-array) with patient-matched control. [PDF]

Leuk Res Rep
Chi K, Song L.
europepmc   +1 more source

Unraveling Novel Genetic Determinants of Thiopurine Response Via TWAS

Clinical Pharmacology &Therapeutics, EarlyView.
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Thiopurines such as 6‐mercaptopurine (6MP) are essential in ALL maintenance therapy. However, dose‐limiting toxicities can significantly disrupt treatment. While genetic variants in TPMT and NUDT15 are known to affect thiopurine response, many patients with normal function ...
Carlotta Bidoli, Wenjian Yang, Seth E. Karol, Marianna Lucafò, Gabriele Stocco, Jun J. Yang   +5 more
wiley   +1 more source

Causal relationship between trunk and lower limb fat mass and intervertebral disc disorders: A 2-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Huang Z, Tian Z, Tian K, Wang Y, Jiang Y.   +4 more
europepmc   +1 more source