Results 221 to 230 of about 306,247 (295)

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

The association between two common levels of apolipoprotein and chronic obstructive pulmonary disease: A Mendelian randomized study. [PDF]

Medicine (Baltimore)
Chen C, Sun Z, Zhong W, Zheng H, Zuo Z, Zhang X, Wang Y, Zhao W, Shen B.   +8 more
europepmc   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, EarlyView.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

Predicting the evolution and persistence of COVID-19 using context-dependent polymorphisms. [PDF]

Sci Rep
Caraway J, Sung W.
europepmc   +1 more source

Association between blood metabolites and chronic respiratory diseases: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Gao P, Ye D, Li Q, Bai L, Xu X, Fang X.
europepmc   +1 more source

Direct single-nucleotide polymorphism genotyping from whole blood without DNA extraction. [PDF]

J Equine Sci
Furukawa R, Tozaki T, Kawate K, Kikuchi M, Ishige T, Fukui E, Kakoi H.   +6 more
europepmc   +1 more source

Single-Nucleotide Polymorphisms in Genes Associated with Mitochondrial and DNA Damage Response Modulate the Risk of Non-Alcoholic Fatty Liver Disease in Humans. [PDF]

Int J Mol Sci
Ziółkowska S, Kosmalski M, Kołodziej Ł, Jarmusz K, Ejsmont M, Pietras T, Jabłkowska A, Jabłkowski M, Szemraj J, Czarny P.   +9 more
europepmc   +1 more source

Predicting immune-related thyroiditis using polygenic risk scores in patients with advanced melanoma. [PDF]

J Immunother Cancer
Tarhini AA, Khaksar MA, Chen Z, Lee SJ, Stephen Hodi F, Li T, Yoder SJ, Streicher H, Sondak VK, Kirkwood JM, Wang X, Kanetsky PA.   +11 more
europepmc   +1 more source

Bayesian Mendelian randomization reveals a protective effect of later age at first sexual intercourse against erectile dysfunction. [PDF]

Medicine (Baltimore)
Wu J, Hui X, Hui X.
europepmc   +1 more source

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.
Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen, Ningning Zhang, Ruirui Zhang, Lan Zhang, Dadong Luo, Junqiang Li, Yaqing Liu, Yunan Wang, Xinyue Duan, Xin Tian, Tiancheng Wang   +10 more
wiley   +1 more source