Results 231 to 240 of about 459,273 (291)

Association of gestational diabetes mellitus with intrahepatic cholestasis of pregnancy: A 2-sample Mendelian randomization analysis utilizing FinnGen consortium data. [PDF]

Medicine (Baltimore)
Yang C, Song W, Lu K, Dang W, Zhao Y, Zhang L, Li M, Wu X, He Y, Wu X.   +9 more
europepmc   +1 more source

UGT1A1 Fragment Analysis: Genotyping the (TA)n Variable Repeat Polymorphism for Clinical Applications

Journal of Clinical Laboratory Analysis, EarlyView.
This study developed a PCR‐based fragment analysis assay for UGT1A1 rs3064744 targeting TA5 (*36), TA6 (*1), TA7 (*28), and TA8 (*37). The assay was CLIA validated with data showing 100% concordance and a sensitivity of 0.5 ng/uL. The assay was then implemented in a patient cohort of n = 940 and the results compared with PharmacoScan.
Ryan N. Baugher, Kristen M. Pike, Teri M. Plona, Stephanie D. Mellott, Todd B. Young, Heidi E. Lawhorn, Stephen M. Hewitt   +6 more
wiley   +1 more source

Association of p53 Pro72Arg Polymorphism with Hepatocellular Carcinoma Risk in Hepatitis B Across Multiethnic Populations. [PDF]

Cancers (Basel)
Kholili U, Hidayat AA, Bintoro UY, Soetjipto S, Aryati A, Alaydrus A, Miftahussurur M.   +6 more
europepmc   +1 more source

Large‐Scale Evaluation of Traditional Chinese Medicines Reveals Potential PPARγ Modulators for Type 2 Diabetes Management

Journal of Clinical Laboratory Analysis, EarlyView.
Identifying novel treatments for diabetic management is always a competitive research topic all over the world. PPAR‐γ is one of the key regulators involved in glucose and lipid metabolism and improves insulin sensitivity and glucose homeostasis. This study investigated the impacts of 639 traditional Chinese medicine (TCM) on PPAR‐γ gene promoter ...
Mingyuan Dou, Shandra Jones, Juan Montes, Jonathan Ritter, Li‐Yu Shih, Chia‐Jung Chan, Ying‐Chou Lin, Min Chen, Shih‐Yin Chen, Ning Wu   +9 more
wiley   +1 more source

Mendelian randomization study finds no causal link between inflammatory bowel disease and cirrhosis. [PDF]

Medicine (Baltimore)
An J, Zhu M, Fu Y, Gao K, Xie H, Ding H, Guo C, Zeng F, Xiong Y.   +8 more
europepmc   +1 more source

Recent Advances in Thalassemia Research: A Comprehensive Assessment From Diagnostic Technologies to Clinical Treatment

Journal of Clinical Laboratory Analysis, EarlyView.
Thalassemia, a common hereditary blood disorder causing impaired globin synthesis and related complications, has seen remarkable progress in recent years due to advancements in genomics and molecular biology. Researchers have identified various gene variants related to thalassemia and improved clinical diagnostic methods, including new genetic testing ...
Chaoqiong Zhou, Ting Chen, Ying Huang, Huali Wang, Dahai He, Feng Wu, Yan Zhang, Lirui Kong   +7 more
wiley   +1 more source

Genomic Insights Into Carbapenem‐Resistant Klebsiella pneumoniae in Pediatric Bloodstream Infections in Zhejiang, China (2019–2024)

Journal of Clinical Laboratory Analysis, EarlyView.
The primary mechanism of carbapenem resistance identified in pediatric CRKP‐BSI strains was the production of Class B metalloenzymes. We report, for the first time, an outbreak of bloodstream infections in a neonatal ward caused by the dissemination of NDM‐1‐producing ST25 K. pneumoniae.
Mingming Zhou, Xiucai Zhang, Zhenjie Chen, Chao Fang, Shixing Liu, Jintao Xia, Yining Zhao, Chenmei Zhang, Hongqiang Shen   +8 more
wiley   +1 more source

Hyperthyroidism drives gout risk: A Mendelian randomization observational study. [PDF]

Medicine (Baltimore)
Pan Y, Zhou S, Luo D.
europepmc   +1 more source

Immune cells and rheumatic heart disease: A 2-sample and Bayesian weighted Mendelian randomization study. [PDF]

Medicine (Baltimore)
Xue S, Jiang H, Liu C, Zhou Y.
europepmc   +1 more source

Genetic polymorphisms influencing meat productivity and quality in Kalmyk cattle of Russia: A systematic review of growth hormone, thyroglobulin, leptin, and calpain-1 genes. [PDF]

Vet World
Chimidova N, Ubushieva A, Ubushieva V, Bochkaeva Z.   +3 more
europepmc   +1 more source