Results 321 to 330 of about 900,745 (376)

Single nucleotide polymorphisms in breast cancer

Oncology Reports, 2004
A limited number of genes have been identified that explain heritable risks of breast cancer (BC). We searched for low-penetrant genes in an association study using two populations: 223 Finnish unselected patients and 172 Polish familial cases, both with locally collected healthy controls.
Ewa Grzybowska, Fabiola Festa, Zhenzhong Zhang, Zhenzhong Zhang, Jolanta Pamula, Rajesh Kumar, Rajesh Kumar, Somali Sanyal, Helena Zientek, Sabrina Angelini, Kari Hemminki, Asta Försti, Wioletta Pekala   +12 more
openaire   +4 more sources

Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection.

ACS Nano, 2012
Graphene materials are being widely used in electrochemistry due to their versatility and excellent properties as platforms for biosensing. However, no records show the use of inherent redox properties of graphene oxide as a label for detection. Here for
A. Bonanni, Chun Kiang Chua, Guanjia Zhao, Zdenek Sofer, M. Pumera   +4 more
semanticscholar   +1 more source

Single Nucleotide Polymorphisms (SNPs)

2014
Single nucleotide polymorphisms (SNPs) have been suggested as a useful tool for dissecting various human complex disorders, classically at a small scale and recently at large genome-wide levels. The advent of new technologies, including chip-based genotyping as well as high-throughput next generation sequencing, has opened new avenues for SNPs to be ...
Batra, Jyotsna, Srinivasan, Srilakshmi, Clements, Judith   +2 more
openaire   +3 more sources

Hemin-graphene hybrid nanosheets with intrinsic peroxidase-like activity for label-free colorimetric detection of single-nucleotide polymorphism.

ACS Nano, 2011
This paper demonstrated for the first time a simple wet-chemical strategy for synthesizing hemin-graphene hybrid nanosheets (H-GNs) through the π-π interactions.
Yujing Guo, Liu Deng, Jing Li, Shaojun Guo, E. Wang, S. Dong   +5 more
semanticscholar   +1 more source

Cytokine Single Nucleotide Polymorphisms in Iran

Journal of Interferon & Cytokine Research, 2006
Overall expression and secretion of cytokines are dependent on genetic nucleotide variations within or adjacent to regulatory regions of cytokine genes. This study allows the comparison of the prevalence of particular genetic markers. In 40 Iranian healthy subjects, cytokine single nucleotide polymorphisms (SNPs) were used to determine allelic and ...
Davood Omrani, Mortaza Bagheri, Isa Abdi-Rad   +2 more
openaire   +3 more sources

Single-Nucleotide Polymorphism Analysis by Pyrosequencing

Analytical Biochemistry, 2000
There is a growing demand for high-throughput methods for analysis of single-nucleotide polymorphic (SNP) positions. Here, we have evaluated a novel sequencing approach, pyrosequencing, for such purposes. Pyrosequencing is a sequencing-by-synthesis method in which a cascade of enzymatic reactions yields detectable light, which is proportional to ...
Baback Gharizadeh, Anna C. Gustafsson, Pål Nyrén, Afshin Ahmadian, Joakim Lundeberg, Mathias Uhlén, Fredrik Sterky   +6 more
openaire   +3 more sources

Single nucleotide polymorphism hunting in cyberspace

Human Mutation, 1998
Large-scale sequencing of human cDNA and genomic DNA libraries has produced a large collection of sequence data in public databases. To date, >900,000 human expressed sequence tag (EST) sequences and >80,000,000 bases of genomic DNA sequence have been deposited in Genbank.
Pui-Yan Kwok, LaDeana W. Hillier, Zhijie Gu   +2 more
openaire   +3 more sources

Genotyping of Single Nucleotide Polymorphisms

2015
Single nucleotide polymorphisms (SNPs) are the most abundant DNA variations in human genome. Numerous reports have indicated that SNPs are closely associated with diseases such as cardiovascular diseases, different types of cancer, and other genetic diseases.
Tian Ye, Ran Tong, Zhiqiang Gao
openaire   +2 more sources

Single Nucleotide Polymorphisms and Their Applications

2007
SNPs are highly abundant in the human genome, explaining most of sequence variation. This makes them a valuable resource for population genetics, evolution, and gene mapping. In this article we have given an overview of the major issues arising in their application to haplotype and haplotype block estimation and genetic association.
Zhaoxia Yu, Rudy Guerra
openaire   +2 more sources

Single nucleotide polymorphisms: aging and diseases

Biogerontology, 2004
Differences of more than 3 million nucleotides can bee seen comparing the genomes of two individuals as a result of single nucleotide polymorphism (SNP). More and more SNPs can be identified and it seems that these alterations are behind of several biological phenomena.
Margit Zeher, Marietta Márka, Imre Semsei, László Urbán, Beáta Bessenyei   +4 more
openaire   +3 more sources