Results 21 to 30 of about 727,358 (304)

COVID‐19 and the risk of Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1953-1961, December 2022., 2022
Abstract Background The coronavirus disease 2019 (COVID‐19) pandemic has had an unprecedented impact on the healthcare system, economy, and society. Studies have reported that COVID‐19 may cause various neurologic symptoms, including cognitive impairment.
Hanyu Zhang, Zengyuan Zhou
wiley   +1 more source

Validation of Customized Cancer Panel for Detecting Somatic Mutations and Copy Number Alterations [PDF]

Genomics & Informatics, 2017
Accurate detection of genomic alterations, especially druggable hotspot mutations in tumors, has become an essential part of precision medicine.
Su-Hye Choi, Seung-Hyun Jung, Yeun-Jun Chung   +2 more
doaj   +1 more source

Algebraic polymorphisms [PDF]

Ergodic Theory and Dynamical Systems, 2008
AbstractIn this paper we consider a special class of polymorphisms with invariant measure, the algebraic polymorphisms of compact groups. A general polymorphism is—by definition—a many-valued map with invariant measure, and the conjugate operator of a polymorphism is a Markov operator (i.e.
Schmidt, Klaus, Vershik, Anatoly M.
openaire   +3 more sources

Early‐onset Alzheimer's disease shows a distinct neuropsychological profile and more aggressive trajectories of cognitive decline than late‐onset

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1962-1973, December 2022., 2022
Abstract Objectives Early‐ and late‐onset Alzheimer's disease (EOAD and LOAD) share the same neuropathological traits but show distinct cognitive features. We aimed to explore baseline and longitudinal outcomes of global and domain‐specific cognitive function in a well characterized cohort of patients with a biomarker‐based diagnosis.
Adrià Tort‐Merino, Neus Falgàs, Isabel E. Allen, Mircea Balasa, Jaume Olives, José Contador, Magdalena Castellví, Jordi Juncà‐Parella, Núria Guillén, Sergi Borrego‐Écija, Bea Bosch, Guadalupe Fernández‐Villullas, Oscar Ramos‐Campoy, Anna Antonell, Lorena Rami, Raquel Sánchez‐Valle, Albert Lladó   +16 more
wiley   +1 more source

A Variant in Is Associated with the Risk of Ankylosing Spondylitis in Koreans [PDF]

Genomics & Informatics, 2017
Ankylosing spondylitis (AS) is a chronic autoinflammatory disease that affects the spine and sacroiliac joints. Regarding its etiology, although HLA-B27 is known to be the strongest genetic factor of AS, much evidence suggests the potential contribution ...
Sung-Min Cho, Seung-Hyun Jung, Yeun-Jun Chung   +2 more
doaj   +1 more source

Association of the leptin receptor Q223R (rs1137101) polymorphism with obesity measures in Sri Lankans [PDF]

, 2020
OBJECTIVE: The role of genetic factors in the development of obesity is largely unreported in Sri Lankans. The Q223R (rs1137101) single nucleotide polymorphism (SNP) of the leptin receptor (LEPR) gene has been associated with obesity measures in various ...
Dalton, C.F., Fernando, D.J., Illangasekera, Y.A., Kumarasiri, P.V.R.   +3 more
core   +1 more source

Blood ties: ABO is a trans-species polymorphism in primates [PDF]

, 2012
The ABO histo-blood group, the critical determinant of transfusion incompatibility, was the first genetic polymorphism discovered in humans. Remarkably, ABO antigens are also polymorphic in many other primates, with the same two amino acid changes ...
A. Venkat, Allison, Becquet, Boren, C. Ober, Calafell, Castric, Charlesworth, Clausen, Diamond, Doxiadis, E. E. Thompson, G. Sella, Goldman, Hobolth, J. Lovstad, J. Moyse, K. Gamble, Kominato, L. Segurel, M. Przeworski, McVean, Oriol, Patterson, Perelman, Reid, Ronquist, S. Ross, S. W. Margulis, Saitou, Scally, Stephens, T. Flutre, Takahata, Wooding, Yamamoto, Yamamoto, Yamamoto, Yang   +38 more
core   +1 more source

The presence of valine at residue 129 in human prion protein accelerates amyloid formation [PDF]

, 2005
The polymorphism at residue 129 of the human PRNP gene modulates disease susceptibility and the clinicopathological phenotypes in human transmissible spongiform encephalopathies.
Baskakov, I, Breydo, L, Disterer, P, Gill, A, James, W, Shaw, M, Tahiri-Alaoui, A   +6 more
core   +1 more source

Maltsev digraphs have a majority polymorphism [PDF]

, 2010
We prove that when a digraph $G$ has a Maltsev polymorphism, then $G$ also has a majority polymorphism. We consider the consequences of this result for the structure of Maltsev graphs and the complexity of the Constraint Satisfaction Problem.Comment: 8 ...
Alexandr Kazda, Bodirsky, Bulatov, Bulatov, Burris, Dalmau, Dalmau, Feder, Jaevons, Nešetřil   +9 more
core   +2 more sources

POLYMORPHISM AND POLYMORPH CHARACTERISATION IN PHARMACEUTICALS

Journal of Biomedical and Pharmaceutical Research, 2019
Polymorphism is the ability of a specific chemical compound to crystallize in more than one crystalline form. Polymorphs had a different arrangement of the molecule in the given crystal lattice and  may properties such as packing properties, thermodynamic properties, spectroscopic properties, kinetic properties, surface properties and mechanical ...
Amit Gosar, Tabrez Shaikh, Sayyed Hussain   +2 more
openaire   +5 more sources