By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Paraoxonase Gene Polymorphisms and Aortic Calcification
International Journal of Gerontology, 2010 Background: Aortic arch calcification is correlated with the extent of atherosclerosis and is a predictor of future cardiovascular risk. The paraoxonase (PON) gene can reduce the risk of atherosclerosis development.
Jinzi Wu +6 more
doaj +1 more source
Paraoxonase gene polymorphisms and haplotype analysis in a stroke population [PDF]
, 2006 Peer reviewedPublisher ...
Cheung, J +6 more
core +2 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosis [PDF]
, 2007 Background Vascular endothelial growth factor (VEGF) has neurotrophic activity which is mediated by its main agonist receptor, VEGFR2. Dysregulation of VEGF causes motor neurone degeneration in a mouse model of amyotrophic lateral sclerosis (ALS), and
Brockington, A. +4 more
core +3 more sources
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
Emotional dimension associated with the migratory experience of adult refugees and asylum seekers
Scientific ReportsThis study explores the impact of the migratory process on the mental health of refugees and asylum seekers arriving in Spain. It examines the feelings and emotions associated with emigration, alongside its underlying causes. A mixed-methods approach was
María José Cáceres-Titos +2 more
doaj +1 more source
The Association between TNF-alpha Gene Polymorphisms and Endometriosis in An Iranian Population [PDF]
International Journal of Fertility and Sterility, 2019 Background Tumor necrosis factor-alpha (TNF-α) is an important cytokine in acute inflammatory response to infective factors. Based on investigation in different populations, it is thought that this response increases in patients with endometrio- sis ...
Babak Babaabasi +4 more
doaj +1 more source
Evidence of uneven selective pressure on different subsets of the conserved human genome : implications for the significance of intronic and intergenic DNA [PDF]
, 2009 Peer reviewedPublisher ...
Davidson, Scott +2 more
core +4 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source