Results 121 to 130 of about 41,111 (239)

Topical Mitomycin C Chemotherapy After Surgical Resection of Conjunctival Amelanotic Melanoma in a Dog

Veterinary Ophthalmology, Volume 29, Issue 4, July 2026.
ABSTRACT Objective To describe the clinical course and outcome of adjuvant topical mitomycin C (MMC) therapy following incomplete resection of a conjunctival amelanotic melanoma in a dog. Animals Studied A 15‐year‐old spayed‐female Shih Tzu presented with a conjunctival mass in the right eye (OD).
Junyeong Ahn, Koangyong Sung, Minwoo Jang, Kangmoon Seo, Seonmi Kang   +4 more
wiley   +1 more source

Clinical Features and Surgical Outcomes of Cats With Presumed Primary Lens Instability: A Retrospective Study of 34 Cases (2018–2022)

Veterinary Ophthalmology, Volume 29, Issue 4, July 2026.
ABSTRACT Objective Describe the clinical features, disease progression, and outcomes of presumed primary lens instability (PLI) in cats, and to assess its association with glaucoma. Animals Studied Thirty‐four cats (68 eyes). Procedures Medical records were reviewed for signalment, clinical history, ophthalmic findings, and treatment.
Havi Sarfaty, Raaya Ezra‐Elia, Nili Kahane, Shai Sandalon, Yifat Segev, Lionel Sebbag   +5 more
wiley   +1 more source

Revisiting Polymyxin B: Pharmacokinetics, Biodistribution and Mechanism(s) of Intrarenal Transport [PDF]

, 2019
Objectives: Despite dose-limiting nephrotoxic potentials, polymyxin B has re-emerged as the last line of therapy against multidrug-resistant Gram-negative bacterial infections.
Manchandani, Pooja
core  

Guidelines for Comparing Circular Dichroism Spectroscopy and Molecular Dynamics Simulations for Biomolecules

ChemPhysChem, Volume 27, Issue 12, 26 June 2026.
A direct comparison is made between circular dichroism (CD) spectroscopy and molecular dynamics (MD) simulations for studying peptide partitioning through biological membranes. The assumptions and limitations of each method is discussed, and case studies are provided for their use.
Cinzia Campus, Marta Roldo, Charles H. Chen, Roja Hadianamrei, Elisabetta Gavini, Christian Jorgensen   +5 more
wiley   +1 more source

MIC breakpoints of XDR Enterobacterales Towards Polymyxin B, Colistin, and Tigecycline - Clinical Insights and Therapeutic Outcomes from A Descriptive Study

Journal of Pure and Applied Microbiology
The prevalence of antibiotic resistance among Gram-negative bacteria, particularly Enterobacterales, is rising. Extensively drug-resistant (XDR) Enterobacterales demonstrate nonsusceptibility to all except two or fewer classes of antibiotics, where it ...
R. Kalaivani, Arunava Kali, Joshy M. Easow   +2 more
doaj   +1 more source

Optimisation of a Novel Class of DNA Gyrase Inhibitors to Improve Antibacterial Activity

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
This article describes efforts to increase the antibacterial activity of a recently reported class of novel DNA gyrase inhibitors known as the isoquinoline sulphonamides by improving their uptake in bacterial cells. As antibiotic resistance continues to rise, the need for new antibacterials is clear.
Meg I. Ferguson, Cerissa C. van Walstijn, Vladyslav Lysenko, Marta A. Wilbrink, David Alencar Araripe, Jeroen M. Punt, Mario van der Stelt, Willem Jespers, Paolo Innocenti, Nathaniel I. Martin   +9 more
wiley   +1 more source

Comparative efficacy of intravenous versus intravenous combined with intrathecal/intracerebral ventricle injection of polymyxin B for Acinetobacter baumannii intracranial infection: A retrospective study

Journal of Global Antimicrobial Resistance
Objective: Intracranial infections caused by Acinetobacter baumannii (A. baumannii) are common and life-threatening. This study aimed to compare the clinical efficacy and risk factors associated with 30-d mortality rates between intravenous (IV ...
Li You, Ru-meng Ding, Ting-ting Liu, Hai-yang Meng, Duo-lu Li   +4 more
doaj   +1 more source

Comparison of the Impact of VRP-034 and Polymyxin B upon Markers of Kidney Injury in Human Proximal Tubule Monolayers In Vitro

Antibiotics
In this study, we assessed the impact of commercially available polymyxin B against VRP-034 (novel formulation of polymyxin B) using a validated in vitro human renal model, aProximateTM. Freshly isolated primary proximal tubule cells (PTCs) were cultured
Keith Pye, Elena Tasinato, Siannah Shuttleworth, Claire Devlin, Colin Brown   +4 more
doaj   +1 more source

Antimicrobial prescribing guidelines for feedlot cattle

Australian Veterinary Journal, Volume 104, Issue 7, Page 413-438, July 2026.
P Cusack, T Batterham, SW Page, GF Browning, JM Norris   +4 more
wiley   +1 more source

Polymyxin B adjuvants against polymyxin B- and carbapenem-resistant Gram-negative bacteria

Future Microbiology
Aim: Polymyxin B (PMB) is one of the few therapeutic options for treating infections caused by carbapenem-resistant Gram-negative bacteria (CR-GNB). However, the emergence of PMB-resistant CR-GNB strains has prompted the exploration of antibiotic adjuvants as potential therapeutic avenues.
João Paulo Salvaterra Pasquini, Paula Assis Queiroz, Pedro Henrique Rodrigues do Amaral, Thalita Camilo da Silva, Patricia de Souza Bonfim Mendonça, Fábio Vandresen, João Pedro Carvalho Ceolis, Regiane Bertin de Lima Scodro, Katiany Rizzieri Caleffi-Ferracioli, Rosilene Fressatti Cardoso, Vera Lúcia Dias Siqueira   +10 more
openaire   +2 more sources