Results 71 to 80 of about 16,842 (191)

The biological essence of synthetic lethality: Bringing new opportunities for cancer therapy

MedComm – Oncology, Volume 3, Issue 1, March 2024.
Synthetic lethality exploits vulnerabilities in cancer cells, targeting aberrant pathways resulting from genetic mutations or pharmacological interventions. This strategy extends beyond the tumor cells to include the tumor microenvironment, such as stromal cells and signaling molecules, to enhance treatment responses and eradicate cancer.
Meiyi Ge, Jian Luo, Yi Wu, Guobo Shen, Xi Kuang   +4 more
wiley   +1 more source

Distinct co-evolution patterns of genes associated to DNA polymerase III DnaE and PolC

BMC Genomics, 2012
Background Bacterial genomes displaying a strong bias between the leading and the lagging strand of DNA replication encode two DNA polymerases III, DnaE and PolC, rather than a single one.
Engelen Stefan, Vallenet David, Médigue Claudine, Danchin Antoine   +3 more
doaj   +1 more source

Escherichia coli strains with precise domain deletions in the ribonuclease RNase E can achieve greatly enhanced levels of membrane protein production

Protein Science, Volume 33, Issue 2, February 2024.
Abstract Escherichia coli is one of the most widely utilized hosts for production of recombinant membrane proteins (MPs). Bacterial MP production, however, is usually accompanied by severe toxicity and low‐level volumetric accumulation. In previous work, we had discovered that co‐expression of RraA, an inhibitor of the RNA‐degrading activity of RNase E,
Eleni Vasilopoulou, Tania Chroumpi, Georgios Skretas   +2 more
wiley   +1 more source

Sequence motifs that distinguish ATP(CTP) : tRNA nucleotidyl transferases from eubacterial poly(A) polymerases [PDF]

, 2004
ATP(CTP):tRNA nucleotidyl transferases, tRNA maturing enzymes found in all organisms, and eubacterial poly(A) polymerases, enzymes involved in mRNA degradation, are so similar that until now their biochemical functions could not be distinguished by their
Keller, W., Martin, G.
core  

Poor Outcome in a Mitochondrial Neurogastrointestinal Encephalomyopathy Patient with a Novel TYMP Mutation: The Need for Early Diagnosis. [PDF]

, 2012
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a devastating autosomal recessive disorder due to mutations in TYMP, which cause loss of function of thymidine phosphorylase (TP), nucleoside accumulation in plasma and tissues and ...
Padovani Alessandro, SCARPELLI, Mauro, Anna Russignan, Padovani, A, PADOVANI, Alessandro, Bereczki, C, Paola Tonin, Bax Bridget E., Buono, R, Filosto Massimiliano, ZAPPINI, Francesca, Filosto M., Russignan, A, Bridget E. Bax, Alessandro Padovani, Zappini, F, Filosto, M, Bereczki Csaba, Bax, BE, Tonin, P, Massimiliano Filosto, Bax B. E., Padovani A., Zombor, M, Tonin Paola, Buono, Romina, Bereczki C., Zombor Melinda, Zombor M., Mauro Scarpelli, Romina Buono, Zappini Francesca, Scarpelli Mauro, Csaba Bereczki, Russignan Anna, Francesca Zappini, RUSSIGNAN, Anna, Buono Romina, TONIN, PAOLA, Melinda Zombor, Scarpelli, M   +40 more
core   +1 more source

Genetic analysis of polynucleotide phosphorylase structure and functions.

, 2007
Polynucleotide phosphorylase (PNPase) is a phosphate-dependent 3' to 5' exonuclease widely diffused among bacteria and eukaryotes. The enzyme, a homotrimer, can also be found associated with the endonuclease RNase E and other proteins in a ...
Consonni C, del Favero M, Tortora P, Briani F, Capizzuto R, Dehò G, Zangrossi S, Greco C, De Gioia L   +8 more
core   +2 more sources

Proteome-wide alterations in an industrial clavulanic acid producing strain of Streptomyces clavuligerus

Synthetic and Systems Biotechnology, 2017
The usefulness of genetic/metabolic engineering for further improvement of industrial strains is subject of discussion because of the general lack of knowledge on genetic alterations introduced by iterative cycles of random mutagenesis in such strains ...
Eser Ünsaldı, Aslıhan Kurt-Kızıldoğan, Birgit Voigt, Dörte Becher, Gülay Özcengiz   +4 more
doaj   +1 more source

The effect of phosphonylmethyl analogs of ribonucleoside 5'-diphosphates on (E. coli) polynucleotide phosphorylase catalyzed reactions

, 1987
Ribonucleoside 5'-O-phosphorylphosphonylmethyl ethers (I) are not substrates of Escherichia coli polynucleoside phosphorylase in the presence of either Mg2+- or Mn2+-ions.
Masahiko Nishizawa, Antonín Holý, Ivan Rosenberg, Ivan Votruba   +3 more
core   +1 more source

Studies on polynucleotide phosphorylase of rhizobia and a new nucleoside diphosphatase of alfalfa and soybean nodules

, 1976
Polynucleotide phosphorylase was purified approximately 75-fold from extracts of Rhizobium meliloti F-28. The enzume was demonstrated to catalyze the polymerization of nucleoside diphosphates, the phosphorolysis of homo- and heteropolyribonucleotides ...
Hunt, Robert E.
core  

Guanosine 5'-diphosphate 3'-diphosphate (ppGpp) as a negative modulator of polynucleotide phosphorylase activity in a 'rare' actinomycete.

, 2010
With the beginning of the idiophase the highly phosphorylated guanylic nucleotides guanosine 5'-diphosphate 3'-diphosphate (ppGpp) and guanosine 5'-triphosphate 3'-diphosphate (pppGpp), collectively referred to as (p)ppGpp, activate stress survival ...
di Summa R, Tredici SM, SICULELLA, Luisa, Alduina R, DAMIANO, FABRIZIO, ALIFANO, Pietro, GNONI, Gabriele Vincenzo   +6 more
core   +2 more sources