Results 91 to 100 of about 17,878 (213)

Exercise serum promotes DNA damage repair and remodels gene expression in colon cancer cells

International Journal of Cancer, Volume 158, Issue 10, Page 2641-2649, 15 May 2026.
What's New? Exercise releases bioactive molecules into the bloodstream that can directly slow cancer cell growth. In colon cancer, this may help limit disease progression. Here, using colon cancer cells, the authors investigated the effects of exercise‐conditioned human serum on DNA repair mechanisms. Notably, acute exercise in humans elicited systemic
Samuel T. Orange, Emily Dodd, Sharanya Nath, Hannah Bowden, Alastair R. Jordan, Hannah Tweddle, Ann Hedley, Ifeoma Chukwuma, Ian Hickson, Sweta Sharma Saha   +9 more
wiley   +1 more source

Fluorimetric and CD Recognition between Various ds-DNA/RNA Depends on a Cyanine Connectivity in Cyanine-guanidiniocarbonyl-pyrrole Conjugate

Molecules, 2020
Two novel isosteric conjugates of guanidiniocarbonyl-pyrrole and 6-bromo-TO (thiazole orange) were prepared, differing only in linker connectivity to cyanine (benzothiazole nitrogen vs. quinoline nitrogen).
Tamara Šmidlehner, Marta Košćak, Ksenija Božinović, Dragomira Majhen, Carsten Schmuck, Ivo Piantanida   +5 more
doaj   +1 more source

Sequences for differential diagnostic of Ehrlichia ruminantium and use thereof [PDF]

, 2006
The invention provides genes that are unique either to Ehrlichia ruminantium strain Gardel or to Ehrlichia ruminantium strain Welgevonden, or allelic couples which are present in both strains but whose sequences differ between the two strains, as genetic
Demaille, Jacques, Ferraz, Conchita, Frutos, Roger, Martinez, Dominique   +3 more
core  

Nickel(0)‐Catalyzed [2+2+2] Cycloadditions of Linked Bisdiynes with Diaryl Alkynes Generates D‐π‐A‐π‐D Bis(arylethynyl)indane‐Based Organic Frameworks as Noncytotoxic Probes for Ds‐DNA/Ds‐RNA

ChemistryEurope, Volume 4, Issue 4, April 2026.
Ni(0)‐catalyzed [2 + 2 + 2] cycloadditions of linked bisdiynes with diarylacetylenes generate highly fluorescent D‐π‐A‐π‐D bis(arylethynyl)indane dyes. They bind strongly to ds‐DNA and ‐RNA leading to significant fluorescence quenching, are nontoxic toward human cell lines, and have potential as multimodal fluorescence, CD, and Raman probes for ...
Robert Ricker, Dijana Pavlović Saftić, Sabine Lorenzen, Johannes Schneider, Alena Neudert, Michelle Kalizki, Johannes Krebs, Florian Kerner, Alexandra Friedrich, Ludwig Zapf, Nils Schopper, Maik Finze, Nina Vukadinović, Lucija Lulić Horvat, Ivo Piantanida, Todd B. Marder   +15 more
wiley   +1 more source

Preserving DNAzyme Stability and Activity in Stool Samples for Clinical Diagnostics

Chemistry–Methods, Volume 6, Issue 4, April 2026.
A RNA‐cleaving DNAzymes often lose activity in stool due to extensive nuclease‐mediated degradation. This work introduces a simple heparin‐based treatment that preserves DNAzyme integrity and catalytic function in this highly challenging matrix, enabling reliable pathogen‐responsive signaling in stool samples.
Soyeon Lee, Jimmy Gu, Bruno J. Salena, Yingfu Li   +3 more
wiley   +1 more source

In Vitro Evidence for Oral Soft Tissue Regenerative Effects of a Polynucleotide–Hyaluronan Formulation

Clinical and Experimental Dental Research
Objectives We aimed to investigate the effects of a polynucleotide–hyaluronan (PN–HA) formulation on human palatal fibroblasts (HPFs) and oral epithelial cells (OKF6/TERT‐2) to assess its potential application in oral soft tissue reconstructive ...
Ina Mladenova, Xiaoqing Song, Cristina Nica, Anton Sculean, Maria B. Asparuhova   +4 more
doaj   +1 more source

Study on Interaction of Cationic Porphyrazine with Synthetic Polynucleotides

Analytical Cellular Pathology, 2013
Interactions of cationic tetrakis (N, N′, N″, N‴- tetramethyltetra-3, 4-pyridinoporphyrazinatozinc (II) (Zn (tmtppa)) with synthetic polynucleotides, poly (G-C) and poly (A-T), and calf thymus DNA have been characterized in 7.5 mM phosphate buffer of pH ...
Hamid Dezhampanah, Soghra Fyzolahjani
doaj   +1 more source

Ribozyme Activity of RNA Nonenzymatically Polymerized from 3′,5′-Cyclic GMP

Entropy, 2013
3′,5′-Cyclic GMP spontaneously nonenzymatically polymerizes in a base-catalyzed reaction affording G oligonucleotides. When reacted with fully or partially sequence-complementary RNA (oligo C), the abiotically generated oligo G RNA displays a typical ...
Samanta Pino, Giovanna Costanzo, Alessandra Giorgi, Jiří Šponer, Judit E. Šponer, Ernesto Di Mauro   +5 more
doaj   +1 more source

No Correlation Between Interferon Signaling and Cytosolic Mitochondrial DNA/RNA Leakage in Cultured Skin Fibroblasts of Patients With Mitochondrial Diseases

European Journal of Immunology, Volume 56, Issue 4, April 2026.
Investigation of IFN signaling in cultured skin fibroblasts from patients with genetically confirmed mitochondrial diseases of diverse origins revealed that altered IFN signaling is an inconsistent feature of these disorders. Cytosolic accumulation of mtDNA and mtRNA was variably detected and showed little correlation with ISG scores.
Manon Marchais, Alessandra Pennisi, Alexandre Pierga, Alice Lepelley, Nicolas Cagnard, Christine Bole, Patrick Nitschke, Mohamed Hamici, Frédéric Rieux‐Laucat, Manuel Schiff, Arnold Munnich, Agnès Rötig   +11 more
wiley   +1 more source

Osteoarthritis: Epidemiology, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Osteoarthritis is a prevalent degenerative joint disease with a growing global burden. Its development involves complex interactions among epidemiological factors, pathological changes, molecular signaling, and epigenetic regulation. Understanding these mechanisms provides insights into disease progression and supports the development of therapeutic ...
Tianrui Chen, Wenlong Chen, Tianpeng Xu, Hong Wang, Yuheng Zhang, Li Wang, Sijie Zhu, Huaqiang Tao, Xing Yang   +8 more
wiley   +1 more source