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Influence of surveillance renal allograft biopsy on diagnosis and prognosis of polyomavirus-associated nephropathy [PDF]

Kidney International, 2003
Polyomavirus-associated nephropathy (PVAN) is an increasingly prevalent cause of allograft dysfunction.In 18 histologically proven cases of PVAN managed by reduced immunosuppression, monitoring of serum creatinine, and repeated biopsy, graft outcomes were correlated with clinical and histologic indices. Six months postdiagnosis the status of each graft
Aleksandar Denic, Matthew D Griffin, James M Gloor   +2 more
exaly   +3 more sources

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A case of polyomavirus-associated nephropathy presenting late after transplantation

Nature Clinical Practice Nephrology, 2008
A 36-year-old white female, who had received a deceased-donor kidney transplant for end-stage renal disease secondary to reflux nephropathy 8 years previously, was referred to a transplant clinic for evaluation following an increase in her serum creatinine level from 123.8 micromol/l to 185.6 micromol/l (1.4 mg/dl to 2.1 mg/dl) over the preceding 9 ...
Shweta, Bansal, M Scott, Lucia, Alexander, Wiseman   +2 more
openaire   +2 more sources

High-Frequency US for BK Polyomavirus–associated Nephropathy after Kidney Transplant

Radiology, 2022
Background BK polyomavirus-associated nephropathy (BKPyVAN) is an important cause of chronic renal allograft dysfunction. However, US features indicative of BKPyVAN have not been fully evaluated. Purpose To assess the value of high-frequency US for the diagnosis of BKPyVAN in kidney transplant recipients.
Daopeng Yang, Bowen Zhuang, Yan Wang, Gang Huang, Ming Xu, Manxia Lin, Wei Wang, Guangliang Huang, Changxi Wang, Xiaoyan Xie, Xiaohua Xie   +10 more
openaire   +2 more sources

Management of polyomavirus-associated nephropathy in renal transplant recipients

Nature Reviews Nephrology, 2012
Polyomavirus-associated nephropathy (PVAN) remains an important infectious complication after renal transplantation, affecting 1-10% of recipients and causing graft loss in approximately 50% of cases. With the lack of effective antiviral therapy, intensive monitoring for BK virus (BKV) using nucleic acid testing or urine cytology--in combination with a
openaire   +2 more sources

Polyomavirus Polymerase Chain Reaction as a Surrogate Marker of Polyomavirus-Associated Nephropathy

Transplantation, 2007
Polyomavirus-associated nephropathy (PVAN) is a significant cause of allograft loss after renal transplantation. A noninvasive assay that can guide the evaluation of PVAN would be of clinical value. We compared the utility of BK virus (BKV) polymerase chain reaction (PCR) and urine cytology in screening for concurrent PVAN.We used PCR to test urine and
Helen B, Viscount, Albert J, Eid, Mark J, Espy, Matthew D, Griffin, Kristine M, Thomsen, William S, Harmsen, Raymund R, Razonable, Thomas F, Smith   +7 more
openaire   +2 more sources

High Incidence of Malignancy in Polyomavirus-Associated Nephropathy in Renal Transplant Recipients

Transplantation Proceedings, 2010
Human polyomaviruses (PV), including JC and BK virus, have been reported to cause polyomavirus-associated nephropathy (PVAN), in renal transplant patients. PV infection has been demonstrated to be associated with malignancies in animals; however, the association between malignancy and viral infections in humans is not clear. We retrospectively reviewed
C-H, Chen, M-C, Wen, M, Wang, J-D, Lian, C-H, Cheng, M-J, Wu, T-M, Yu, Y-W, Chuang, D, Chang, K-H, Shu   +9 more
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BK Polyomavirus‐associated nephropathy managed by screening policy in a real‐life setting

Transplant Infectious Disease, 2019
AbstractBackgroundBK polyomavirus‐associated nephropathy (PyVAN) is an important complication after kidney transplantation. Prevalence ranges from 1% to 10%, and graft loss occurs in approximately 50% of the cases. There is no effective treatment, so early viral detection with immunosuppression tapering is the current strategy to prevent PyVAN.AimsTo ...
Fernanda Vianna Vacilotto Raupp, Gisele Meinerz, Cynthia Keitel da Silva, Patrícia Campos d’Almeida Bianco, João Carlos Goldani, Karla Lais Pegas, Josiane Borges Stolfo, Valter Duro Garcia, Elizete Keitel   +8 more
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Screening for polyomavirus associated nephropathy in renal transplantation with blood viral load measurement

Journal of Clinical Virology, 2009
Polyomavirus associated nephropathy (PVAN) is an important cause of graft failure in the renal transplant population. It has been shown that viremia precedes PVAN, suggesting that measurement of blood viral load could be used for PVAN screening.To verify the utility of BK virus (BKV) blood viral load measurement for PVAN screening in the renal ...
Alexandre A, Boudreault, Chantal, Courtemanche, Eva, Latulippe, Isabelle, Côté, Isabelle, Houde, Louise, Deschênes   +5 more
openaire   +2 more sources

Early identification of renal transplant recipients with high risk of polyomavirus-associated nephropathy

Medical Microbiology and Immunology, 2015
Polyomavirus BK (BKPyV) is ubiquitous among humans. Following primary infection, the virus remains latent predominantly in the hosts' uroepithelial cells. Up to 10 % of renal transplant recipients show a viral reactivation that can lead to polyomavirus-associated nephropathy (PyVAN).
Teutsch, K., Schweitzer, Finja, Knops, Elena, Kaiser, Rolf, Pfister, Herbert J., Verheyen, Jens, Göbel, H., Cingöz, T., Di Cristanziano, Veronica   +8 more
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Polyomavirus-associated nephropathy: critical issues in virological monitoring.

The new microbiologica, 2009
Polyomavirus-associated nephropathy is one of the most common viral complications in renal transplant recipients. Viral replication is the single common feature of all patients at risk of nephropathy. Therefore, screening for virus replication allows for the identification of patients at risk of developing nephropathy and permits earlier intervention ...
CAVALLO, Rossana, BERGALLO, Massimiliano, SIDOTI, Francesca, Astegiano S, TERLIZZI, Maria Elena, Costa C.   +5 more
openaire   +2 more sources